2PNC
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![BU of 2pnc by Molmil](/molmil-images/mine/2pnc) | Crystal Structure of Bovine Plasma Copper-Containing Amine Oxidase in Complex with Clonidine | 分子名称: | 2,6-DICHLORO-N-IMIDAZOLIDIN-2-YLIDENEANILINE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Cendron, L, Holt, A, Smith, D.J, Zanotti, G, Rigo, A, Di Paolo, M.L. | 登録日 | 2007-04-24 | 公開日 | 2008-02-26 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Multiple binding sites for substrates and modulators of semicarbazide-sensitive amine oxidases: kinetic consequences Mol.Pharmacol., 73, 2008
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2XFO
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![BU of 2xfo by Molmil](/molmil-images/mine/2xfo) | tranylcypromine-inhibited human monoamine oxidase B Ile199Ala mutant in complex with 2-(2-benzofuranyl)-2-imidazoline | 分子名称: | 2-(2-BENZOFURANYL)-2-IMIDAZOLINE, 3-PHENYLPROPANAL, Amine oxidase [flavin-containing] B, ... | 著者 | Bonivento, D, Milczek, E.M, McDonald, G.R, Binda, C, Holt, A, Edmondson, D.E, Mattevi, A. | 登録日 | 2010-05-26 | 公開日 | 2010-10-06 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Potentiation of ligand binding through cooperative effects in monoamine oxidase B. J. Biol. Chem., 285, 2010
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2XFP
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![BU of 2xfp by Molmil](/molmil-images/mine/2xfp) | Isatin-inhibited human monoamine oxidase B in complex with 2-(2- benzofuranyl)-2-imidazoline | 分子名称: | 2-(2-BENZOFURANYL)-2-IMIDAZOLINE, Amine oxidase [flavin-containing] B, FLAVIN-ADENINE DINUCLEOTIDE, ... | 著者 | Bonivento, D, Milczek, E.M, McDonald, G.R, Binda, C, Holt, A, Edmondson, D.E, Mattevi, A. | 登録日 | 2010-05-26 | 公開日 | 2010-10-06 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.66 Å) | 主引用文献 | Potentiation of ligand binding through cooperative effects in monoamine oxidase B. J. Biol. Chem., 285, 2010
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2XCG
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![BU of 2xcg by Molmil](/molmil-images/mine/2xcg) | Tranylcypromine-inhibited human monoamine oxidase B in complex with 2- (2-benzofuranyl)-2-imidazoline | 分子名称: | 2-(2-BENZOFURANYL)-2-IMIDAZOLINE, 3-PHENYLPROPANAL, Amine oxidase [flavin-containing] B, ... | 著者 | Bonivento, D, Milczek, E.M, McDonald, G.R, Binda, C, Holt, A, Edmondson, D.E, Mattevi, A. | 登録日 | 2010-04-23 | 公開日 | 2010-10-06 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Potentiation of ligand binding through cooperative effects in monoamine oxidase B. J. Biol. Chem., 285, 2010
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2XFN
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![BU of 2xfn by Molmil](/molmil-images/mine/2xfn) | Human monoamine oxidase B in complex with 2-(2-benzofuranyl)-2- imidazoline | 分子名称: | 2-(2-BENZOFURANYL)-2-IMIDAZOLINE, Amine oxidase [flavin-containing] B, FLAVIN-ADENINE DINUCLEOTIDE, ... | 著者 | Bonivento, D, Milczek, E.M, McDonald, G.R, Binda, C, Holt, A, Edmondson, D.E, Mattevi, A. | 登録日 | 2010-05-26 | 公開日 | 2010-10-06 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Potentiation of ligand binding through cooperative effects in monoamine oxidase B. J. Biol. Chem., 285, 2010
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2XFQ
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![BU of 2xfq by Molmil](/molmil-images/mine/2xfq) | Rasagiline-inhibited human monoamine oxidase B in complex with 2-(2- benzofuranyl)-2-imidazoline | 分子名称: | (1R)-N-(prop-2-en-1-yl)-2,3-dihydro-1H-inden-1-amine, 2-(2-BENZOFURANYL)-2-IMIDAZOLINE, Amine oxidase [flavin-containing] B, ... | 著者 | Bonivento, D, Milczek, E.M, McDonald, G.R, Binda, C, Holt, A, Edmondson, D.E, Mattevi, A. | 登録日 | 2010-05-26 | 公開日 | 2010-10-06 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Potentiation of ligand binding through cooperative effects in monoamine oxidase B. J. Biol. Chem., 285, 2010
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3ZNH
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![BU of 3znh by Molmil](/molmil-images/mine/3znh) | Crimean Congo Hemorrhagic Fever Virus OTU domain in complex with ubiquitin-propargyl. | 分子名称: | POLYUBIQUITIN-B, UBIQUITIN THIOESTERASE | 著者 | Ekkebus, R, vanKasteren, S.I, Kulathu, Y, Scholten, A, Berlin, I, deJong, A, Goerdayal, G, Neefjes, J, Heck, A.J.R, Komander, D, Ovaa, H. | 登録日 | 2013-02-14 | 公開日 | 2013-02-27 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | On Terminal Alkynes that Can React with Active-Site Cysteine Nucleophiles in Proteases. J.Am.Chem.Soc., 135, 2013
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3DPU
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![BU of 3dpu by Molmil](/molmil-images/mine/3dpu) | RocCOR domain tandem of Rab family protein (Roco) | 分子名称: | Rab family protein | 著者 | Gotthardt, K, Weyand, M, Kortholt, A, Van Haastert, P.J.M, Wittinghofer, A. | 登録日 | 2008-07-09 | 公開日 | 2008-08-12 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structure of the Roc-COR domain tandem of C. tepidum, a prokaryotic homologue of the human LRRK2 Parkinson kinase Embo J., 27, 2008
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3DPT
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![BU of 3dpt by Molmil](/molmil-images/mine/3dpt) | COR domain of Rab family protein (Roco) | 分子名称: | Rab family protein | 著者 | Gotthardt, K, Weyand, M, Kortholt, A, Van Haastert, P.J.M, Wittinghofer, A. | 登録日 | 2008-07-09 | 公開日 | 2008-08-12 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structure of the Roc-COR domain tandem of C. tepidum, a prokaryotic homologue of the human LRRK2 Parkinson kinase Embo J., 27, 2008
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4YZM
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![BU of 4yzm by Molmil](/molmil-images/mine/4yzm) | Humanized Roco4 bound to LRRK2-In1 | 分子名称: | 2-[(2-methoxy-4-{[4-(4-methylpiperazin-1-yl)piperidin-1-yl]carbonyl}phenyl)amino]-5,11-dimethyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one, MAGNESIUM ION, Probable serine/threonine-protein kinase roco4 | 著者 | Gilsbach, B.K, Messias, A.C, Ito, G, Sattler, M, Alessi, D.R, Wittinghofer, A, Kortholt, A. | 登録日 | 2015-03-25 | 公開日 | 2015-05-06 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structural Characterization of LRRK2 Inhibitors. J.Med.Chem., 58, 2015
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4YZN
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![BU of 4yzn by Molmil](/molmil-images/mine/4yzn) | Humanized Roco4 bound to Compound 19 | 分子名称: | (4-{[4-(cyclopropylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}-2-fluoro-5-methoxyphenyl)(morpholin-4-yl)methanone, Probable serine/threonine-protein kinase roco4 | 著者 | Gilsbach, B.K, Messias, A.C, Ito, G, Sattler, M, Alessi, D.R, Wittinghofer, A, Kortholt, A. | 登録日 | 2015-03-25 | 公開日 | 2015-05-06 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Structural Characterization of LRRK2 Inhibitors. J.Med.Chem., 58, 2015
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4F0G
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![BU of 4f0g by Molmil](/molmil-images/mine/4f0g) | |
4F0F
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![BU of 4f0f by Molmil](/molmil-images/mine/4f0f) | Crystal Structure of the Roco4 Kinase Domain bound to AppCp from D. discoideum | 分子名称: | PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, Serine/threonine-protein kinase roco4 | 著者 | Gilsbach, B.K, Vetter, I.R, Wittinghofer, A, Kortholt, A. | 登録日 | 2012-05-04 | 公開日 | 2012-06-27 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations. Proc.Natl.Acad.Sci.USA, 109, 2012
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4F1M
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![BU of 4f1m by Molmil](/molmil-images/mine/4f1m) | Crystal Structure of the G1179S Roco4 Kinase Domain bound to AppCp from D. discoideum. | 分子名称: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... | 著者 | Gilsbach, B.K, Vetter, I.R, Wittinghofer, A, Kortholt, A. | 登録日 | 2012-05-07 | 公開日 | 2012-06-27 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | 主引用文献 | Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations. Proc.Natl.Acad.Sci.USA, 109, 2012
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4F1O
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![BU of 4f1o by Molmil](/molmil-images/mine/4f1o) | Crystal Structure of the L1180T mutant Roco4 Kinase Domain from D. discoideum bound to AppCp | 分子名称: | PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, Serine/threonine-protein kinase roco4 | 著者 | Gilsbach, B.K, Vetter, I.R, Wittinghofer, A, Kortholt, A. | 登録日 | 2012-05-07 | 公開日 | 2012-06-27 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations. Proc.Natl.Acad.Sci.USA, 109, 2012
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4F1T
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![BU of 4f1t by Molmil](/molmil-images/mine/4f1t) | Crystal Structure of the Roco4 Kinase Domain from D. discoideum bound to the ROCK Inhibitor H1152 | 分子名称: | (S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE, Serine/threonine-protein kinase roco4 | 著者 | Gilsbach, B.K, Vetter, I.R, Wittinghofer, A, Kortholt, A. | 登録日 | 2012-05-07 | 公開日 | 2012-06-27 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations. Proc.Natl.Acad.Sci.USA, 109, 2012
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2XFU
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![BU of 2xfu by Molmil](/molmil-images/mine/2xfu) | Human monoamine oxidase B with tranylcypromine | 分子名称: | 3-PHENYLPROPANAL, Amine oxidase [flavin-containing] B, [[(2R,3S,4S)-5-[(4AS)-7,8-DIMETHYL-2,4-DIOXO-4A,5-DIHYDROBENZO[G]PTERIDIN-10-YL]-2,3,4-TRIHYDROXY-PENTOXY]-HYDROXY-PHOSPHORYL] [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL HYDROGEN PHOSPHATE | 著者 | Binda, C, Li, M, Hubalek, F, Restelli, N, Edmondson, D.E, Mattevi, A. | 登録日 | 2010-05-26 | 公開日 | 2010-06-09 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Potentiation of ligand binding through cooperative effects in monoamine oxidase B. J. Biol. Chem., 285, 2010
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3NG7
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![BU of 3ng7 by Molmil](/molmil-images/mine/3ng7) | |
7M2M
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![BU of 7m2m by Molmil](/molmil-images/mine/7m2m) | NMR Structure of GCAP5 | 分子名称: | Guanylate cyclase activator 1A, MAGNESIUM ION | 著者 | Ames, J.B, Cudia, D.L. | 登録日 | 2021-03-17 | 公開日 | 2021-10-20 | 最終更新日 | 2021-11-03 | 実験手法 | SOLUTION NMR | 主引用文献 | NMR and EPR-DEER Structure of a Dimeric Guanylate Cyclase Activator Protein-5 from Zebrafish Photoreceptors. Biochemistry, 60, 2021
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5IL7
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![BU of 5il7 by Molmil](/molmil-images/mine/5il7) | |
8VSX
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![BU of 8vsx by Molmil](/molmil-images/mine/8vsx) | NMR Structure of GCAP5 R22A | 分子名称: | Guanylyl cyclase-activating protein 1 | 著者 | Cudia, D.L, Ames, J.B. | 登録日 | 2024-01-24 | 公開日 | 2024-05-08 | 最終更新日 | 2024-06-05 | 実験手法 | SOLUTION NMR | 主引用文献 | NMR Structure of Retinal Guanylate Cyclase Activating Protein 5 (GCAP5) with R22A Mutation That Abolishes Dimerization and Enhances Cyclase Activation. Biochemistry, 63, 2024
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6V9C
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![BU of 6v9c by Molmil](/molmil-images/mine/6v9c) | Crystal structure of FGFR4 kinase domain in complex with covalent inhibitor | 分子名称: | Fibroblast growth factor receptor 4, N-[(3R,4S)-4-{[6-(2,6-dichloro-3,5-dimethoxyphenyl)-8-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl]amino}oxolan-3-yl]prop-2-enamide, SULFATE ION | 著者 | Liu, J, Liu, H. | 登録日 | 2019-12-13 | 公開日 | 2020-03-25 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Discovery of Selective, Covalent FGFR4 Inhibitors with Antitumor Activity in Models of Hepatocellular Carcinoma. Acs Med.Chem.Lett., 11, 2020
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4WNR
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![BU of 4wnr by Molmil](/molmil-images/mine/4wnr) | |
6HLU
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![BU of 6hlu by Molmil](/molmil-images/mine/6hlu) | |
5HVZ
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![BU of 5hvz by Molmil](/molmil-images/mine/5hvz) | Crystal structure of smAKAP AKB domain bound RIa dimerization/docking (D/D) complex at 2.0 A resolution | 分子名称: | Small membrane A-kinase anchor protein, cAMP-dependent protein kinase type I-alpha regulatory subunit | 著者 | Wu, J, Burgers, P.P, Bruystens, J, Heck, A.J.R, Taylor, S.S. | 登録日 | 2016-01-28 | 公開日 | 2016-04-20 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure of smAKAP and its regulation by PKA-mediated phosphorylation. Febs J., 283, 2016
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