4YZM

Humanized Roco4 bound to LRRK2-In1

Summary for 4YZM

• Entry DOI: 10.2210/pdb4yzm/pdb
• Descriptor: Probable serine/threonine-protein kinase roco4, 2-[(2-methoxy-4-{[4-(4-methylpiperazin-1-yl)piperidin-1-yl]carbonyl}phenyl)amino]-5,11-dimethyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: roco-protein, kinase, lrrk2, inhibitor, transferase
• Biological source: Dictyostelium discoideum (Slime mold)
• Total number of polymer chains: 2
• Total formula weight: 66287.00

Authors

Gilsbach, B.K.,Messias, A.C.,Ito, G.,Sattler, M.,Alessi, D.R.,Wittinghofer, A.,Kortholt, A. (deposition date: 2015-03-25, release date: 2015-05-06, Last modification date: 2024-01-10)

• Primary citation: Gilsbach, B.K.,Messias, A.C.,Ito, G.,Sattler, M.,Alessi, D.R.,Wittinghofer, A.,Kortholt, A.; Structural Characterization of LRRK2 Inhibitors.; J.Med.Chem., 58:3751-3756, 2015; PubMed: 25897865; DOI: 10.1021/jm5018779

Experimental method

X-RAY DIFFRACTION (3 Å)