4YZM
Humanized Roco4 bound to LRRK2-In1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Probable serine/threonine-protein kinase roco4 | polymer | 287 | 32548.5 | 2 | UniProt (Q6XHB2) Pfam (PF07714) | Dictyostelium discoideum (Slime mold) | Ras of complex proteins and C-terminal of roc 4 |
| 2 | C, E (A, B) | 2-[(2-methoxy-4-{[4-(4-methylpiperazin-1-yl)piperidin-1-yl]carbonyl}phenyl)amino]-5,11-dimethyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one | non-polymer | 570.7 | 2 | Chemie (4K4) | |||
| 3 | D, F (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 36 | Chemie (HOH) |
Sequence modifications
A, B: 1019 - 1292 (UniProt: Q6XHB2)
| PDB | External Database | Details |
|---|---|---|
| Gly 1006 | - | expression tag |
| Ala 1007 | - | expression tag |
| Met 1008 | - | expression tag |
| Gly 1009 | - | expression tag |
| Gly 1010 | - | expression tag |
| Ser 1011 | - | expression tag |
| Glu 1012 | - | expression tag |
| Phe 1013 | - | expression tag |
| Pro 1014 | - | expression tag |
| Lys 1015 | - | expression tag |
| Ser 1016 | - | expression tag |
| Arg 1017 | - | expression tag |
| Leu 1018 | - | expression tag |
| Leu 1107 | Phe 1107 | engineered mutation |
| Leu 1161 | Phe 1161 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 65097.0 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1190.0 | |
| All* | Total formula weight | 66287.0 |
