4YZN

Humanized Roco4 bound to Compound 19

Summary for 4YZN

• Entry DOI: 10.2210/pdb4yzn/pdb
• Related: 4YZM
• Descriptor: Probable serine/threonine-protein kinase roco4, (4-{[4-(cyclopropylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}-2-fluoro-5-methoxyphenyl)(morpholin-4-yl)methanone (3 entities in total)
• Functional Keywords: roco-protein, kinase, lrrk2, inhibitor, roco4, transferase
• Biological source: Dictyostelium discoideum (Slime mold)
• Total number of polymer chains: 1
• Total formula weight: 33003.91

Authors

Gilsbach, B.K.,Messias, A.C.,Ito, G.,Sattler, M.,Alessi, D.R.,Wittinghofer, A.,Kortholt, A. (deposition date: 2015-03-25, release date: 2015-05-06, Last modification date: 2024-01-10)

• Primary citation: Gilsbach, B.K.,Messias, A.C.,Ito, G.,Sattler, M.,Alessi, D.R.,Wittinghofer, A.,Kortholt, A.; Structural Characterization of LRRK2 Inhibitors.; J.Med.Chem., 58:3751-3756, 2015; PubMed: 25897865; DOI: 10.1021/jm5018779

Experimental method

X-RAY DIFFRACTION (1.55 Å)