4YZN
Humanized Roco4 bound to Compound 19
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Probable serine/threonine-protein kinase roco4 | polymer | 287 | 32548.5 | 1 | UniProt (Q6XHB2) Pfam (PF07714) | Dictyostelium discoideum (Slime mold) | Ras of complex proteins and C-terminal of roc 4 |
| 2 | B (A) | (4-{[4-(cyclopropylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}-2-fluoro-5-methoxyphenyl)(morpholin-4-yl)methanone | non-polymer | 455.4 | 1 | Chemie (4K5) | |||
| 3 | C (A) | water | water | 18.0 | 214 | Chemie (HOH) |
Sequence modifications
A: 1019 - 1292 (UniProt: Q6XHB2)
| PDB | External Database | Details |
|---|---|---|
| Gly 1006 | - | expression tag |
| Ala 1007 | - | expression tag |
| Met 1008 | - | expression tag |
| Gly 1009 | - | expression tag |
| Gly 1010 | - | expression tag |
| Ser 1011 | - | expression tag |
| Glu 1012 | - | expression tag |
| Phe 1013 | - | expression tag |
| Pro 1014 | - | expression tag |
| Lys 1015 | - | expression tag |
| Ser 1016 | - | expression tag |
| Arg 1017 | - | expression tag |
| Leu 1018 | - | expression tag |
| Leu 1107 | Phe 1107 | engineered mutation |
| Leu 1161 | Phe 1161 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 32548.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 455.4 | |
| All* | Total formula weight | 33003.9 |
