8BE1
 
 | | SARS-CoV-2 RBD in complex with a Fab fragment of a neutralising antibody mRBD2 | | 分子名称: | Antibody heavy chain, Antibody light chain, SULFATE ION, ... | | 著者 | Lulla, A, Brear, P, Fischer, K, Hollfelder, F, Hyvonen, M. | | 登録日 | 2022-10-21 | | 公開日 | 2023-01-25 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | | 主引用文献 | Microfluidics-enabled fluorescence-activated cell sorting of single pathogen-specific antibody secreting cells for the rapid discovery of monoclonal antibodies
Biorxiv, 2023
|
|
6HQU
 | | Humanised RadA mutant HumRadA22 in complex with a recombined BRC repeat 8-2 | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Breast cancer type 2 susceptibility, DNA repair and recombination protein RadA, ... | | 著者 | Pantelejevs, T, Lindenburg, L, Hyvonen, M, Hollfelder, F. | | 登録日 | 2018-09-25 | | 公開日 | 2019-10-09 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | | 主引用文献 | Improved RAD51 binders through motif shuffling based on the modularity of BRC repeats.
Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
6YV5
 | | Crystal Structure of Serine protease SplB N3Q/S154R from Staphylococcus aureus | | 分子名称: | SODIUM ION, Serine protease | | 著者 | Rangel Pereira, M.R, Brear, P, Knyphausen, P, Jermutus, L, Hollfelder, F. | | 登録日 | 2020-04-27 | | 公開日 | 2021-05-12 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | | 主引用文献 | Crystal Structure of Serine protease SplB N3Q/S154R from Staphylococcus aureus
To Be Published
|
|
6YV6
 | | Crystal Structure of Serine protease SplB N2K/N3Q/S154R from Staphylococcus aureus | | 分子名称: | DI(HYDROXYETHYL)ETHER, PENTAETHYLENE GLYCOL, Serine protease | | 著者 | Rangel Pereira, M.R, Brear, P, Knyphausen, P, Jermutus, L, Hollfelder, F. | | 登録日 | 2020-04-27 | | 公開日 | 2021-05-12 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.36 Å) | | 主引用文献 | Crystal Structure of Serine protease SplB N2K/N3Q/S154R from Staphylococcus aureus
to be published
|
|
6FNY
 | | CRYSTAL STRUCTURE OF A CHOLINE SULFATASE FROM SINORHIZOBIUM MELLILOTI | | 分子名称: | CALCIUM ION, Choline-sulfatase | | 著者 | Valkov, E, Van Loo, B, Hollfelder, F, Hyvonen, M. | | 登録日 | 2018-02-05 | | 公開日 | 2018-02-28 | | 最終更新日 | 2018-04-04 | | 実験手法 | X-RAY DIFFRACTION (2.79 Å) | | 主引用文献 | Structural and Mechanistic Analysis of the Choline Sulfatase from Sinorhizobium melliloti: A Class I Sulfatase Specific for an Alkyl Sulfate Ester.
J. Mol. Biol., 430, 2018
|
|
4ZI5
 | | Crystal Structure of Dienelactone Hydrolase-like Promiscuous Phospotriesterase P91 from Metagenomic Libraries | | 分子名称: | CHLORIDE ION, MAGNESIUM ION, P91 | | 著者 | Colin, P.-Y, Fischer, G, Hyvonen, M, Hollfelder, F. | | 登録日 | 2015-04-27 | | 公開日 | 2016-02-17 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.702 Å) | | 主引用文献 | Ultrahigh-throughput discovery of promiscuous enzymes by picodroplet functional metagenomics.
Nat Commun, 6, 2015
|
|
5AJ9
 | | G7 mutant of PAS, arylsulfatase from Pseudomonas Aeruginosa | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ARYLSULFATASE, CALCIUM ION, ... | | 著者 | Miton, C.M, Fischer, G, Jonas, S, Mohammed, M.F, Loo, B.v, Kintses, B, Hyvonen, M, Tokuriki, N, Hollfelder, F. | | 登録日 | 2015-02-20 | | 公開日 | 2016-03-16 | | 最終更新日 | 2019-04-24 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Evolutionary repurposing of a sulfatase: A new Michaelis complex leads to efficient transition state charge offset.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
|
|
4UPH
 | | Crystal Structure of Phosphonate Monoester Hydrolase of Agrobacterium radiobacter | | 分子名称: | CHLORIDE ION, MAGNESIUM ION, SULFATASE (SULFURIC ESTER HYDROLASE) PROTEIN | | 著者 | Fischer, G, Loo, B.v, Hyvonen, M, Hollfelder, F. | | 登録日 | 2014-06-17 | | 公開日 | 2015-07-01 | | 最終更新日 | 2019-07-10 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Balancing Specificity and Promiscuity in Enzyme Evolution: Multidimensional Activity Transitions in the Alkaline Phosphatase Superfamily.
J.Am.Chem.Soc., 141, 2019
|
|
4UPL
 | | Dimeric sulfatase SpAS2 from Silicibacter pomeroyi | | 分子名称: | SULFATASE FAMILY PROTEIN, ZINC ION | | 著者 | Jonas, S, van Loo, B, Hollfelder, F, Hyvonen, M. | | 登録日 | 2014-06-17 | | 公開日 | 2015-07-01 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.805 Å) | | 主引用文献 | Balancing Specificity and Promiscuity in Enzyme Evolution: Multidimensional Activity Transitions in the Alkaline Phosphatase Superfamily.
J.Am.Chem.Soc., 141, 2019
|
|
4UPI
 | | Dimeric sulfatase SpAS1 from Silicibacter pomeroyi | | 分子名称: | SULFATASE FAMILY PROTEIN, ZINC ION | | 著者 | Jonas, S, van Loo, B, Hollfelder, F, Hyvonen, M. | | 登録日 | 2014-06-17 | | 公開日 | 2015-07-01 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | | 主引用文献 | Balancing Specificity and Promiscuity in Enzyme Evolution: Multidimensional Activity Transitions in the Alkaline Phosphatase Superfamily.
J.Am.Chem.Soc., 141, 2019
|
|
4UPK
 | |
2W8S
 | | CRYSTAL STRUCTURE OF A catalytically promiscuous PHOSPHONATE MONOESTER HYDROLASE FROM Burkholderia caryophylli | | 分子名称: | FE (III) ION, GLYCEROL, PHOSPHONATE MONOESTER HYDROLASE, ... | | 著者 | Jonas, S, van Loo, B, Hyvonen, M, Hollfelder, F. | | 登録日 | 2009-01-19 | | 公開日 | 2010-02-23 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | An Efficient, Multiply Promiscuous Hydrolase in the Alkaline Phosphatase Superfamily.
Proc.Natl.Acad.Sci.USA, 107, 2010
|
|
4CXS
 | | G4 mutant of PAS, arylsulfatase from Pseudomonas aeruginosa, in complex with Phenylphosphonic acid | | 分子名称: | ARYLSULFATASE, CALCIUM ION, SULFATE ION, ... | | 著者 | Miton, C.M, Jonas, S, Mohammed, M.F, Fischer, G, Loo, B.v, Kintses, B, Hyvonen, M, Tokuriki, N, Hollfelder, F. | | 登録日 | 2014-04-08 | | 公開日 | 2015-05-13 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Evolutionary repurposing of a sulfatase: A new Michaelis complex leads to efficient transition state charge offset.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
|
|
7QEA
 | | Crystal structure of fluorescein-di-Beta-D-glucuronide bound to a mutant of SN243 (D415A) | | 分子名称: | (2~{S},3~{S},4~{S},5~{R},6~{S})-3,4,5-tris(oxidanyl)-6-[(1~{R})-6'-oxidanyl-3-oxidanylidene-spiro[2-benzofuran-1,9'-xanthene]-3'-yl]oxy-oxane-2-carboxylic acid, ACETATE ION, SN243, ... | | 著者 | Neun, S, Brear, P, Campbell, E, Omari, K, Wagner, O, Hyvonen, M, Hollfelder, F. | | 登録日 | 2021-12-01 | | 公開日 | 2022-10-12 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | | 主引用文献 | Functional metagenomic screening identifies an unexpected beta-glucuronidase.
Nat.Chem.Biol., 18, 2022
|
|
7QEF
 | | Crystal structure of para-nitrophenyl-Beta-D-glucuronide bound to a mutant of SN243 (D415A) | | 分子名称: | 4-nitrophenyl beta-D-glucopyranosiduronic acid, ACETATE ION, SN243, ... | | 著者 | Neun, S, Brear, P, Campbell, E, Omari, K, Wagner, O, Hyvonen, M, Hollfelder, F. | | 登録日 | 2021-12-02 | | 公開日 | 2022-10-12 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | | 主引用文献 | Functional metagenomic screening identifies an unexpected beta-glucuronidase.
Nat.Chem.Biol., 18, 2022
|
|
7QG4
 | | Apo crystal structure of a mutant of SN243 (D415N) | | 分子名称: | SN243, SULFATE ION, ZINC ION | | 著者 | Neun, S, Brear, P, Campbell, E, Omari, K, Wagner, O, Hyvonen, M, Hollfelder, F. | | 登録日 | 2021-12-07 | | 公開日 | 2022-10-12 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.08 Å) | | 主引用文献 | Functional metagenomic screening identifies an unexpected beta-glucuronidase.
Nat.Chem.Biol., 18, 2022
|
|
7QE2
 | | Crystal structure of D-glucuronic acid bound to SN243 | | 分子名称: | ACETATE ION, SN243, SULFATE ION, ... | | 著者 | Neun, S, Brear, P, Campbell, E, Omari, K, Wagner, O, Hyvonen, M, Hollfelder, F. | | 登録日 | 2021-12-01 | | 公開日 | 2022-10-12 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Functional metagenomic screening identifies an unexpected beta-glucuronidase.
Nat.Chem.Biol., 18, 2022
|
|
7QE1
 | | Crystal structure of apo SN243 | | 分子名称: | SN243, ZINC ION | | 著者 | Neun, S, Brear, P, Campbell, E, Omari, K, Wagner, O, Hyvonen, M, Hollfelder, F. | | 登録日 | 2021-12-01 | | 公開日 | 2022-10-12 | | 最終更新日 | 2023-03-29 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Functional metagenomic screening identifies an unexpected beta-glucuronidase.
Nat.Chem.Biol., 18, 2022
|
|
4CXU
 | | G4 mutant of PAS, arylsulfatase from Pseudomonas Aeruginosa, in complex with 3-Br-Phenolphenylphosphonate | | 分子名称: | 3-bromophenyl hydrogen (S)-phenylphosphonate, ARYLSULFATASE, CALCIUM ION | | 著者 | Miton, C.M, Jonas, S, Mohammed, M.F, Fischer, G, Loo, B.v, Kintses, B, Hyvonen, M, Tokuriki, N, Hollfelder, F. | | 登録日 | 2014-04-08 | | 公開日 | 2015-04-22 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | | 主引用文献 | Evolutionary repurposing of a sulfatase: A new Michaelis complex leads to efficient transition state charge offset.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
|
|
7QEE
 | | SN243 mutant D415N bound to para-nitrophenyl-Beta-D-glucuronide | | 分子名称: | 4-nitrophenyl beta-D-glucopyranosiduronic acid, SN243, SULFATE ION, ... | | 著者 | Neun, S, Brear, P, Campbell, E, Omari, K, Wagner, O, Hyvonen, M, Hollfelder, F. | | 登録日 | 2021-12-02 | | 公開日 | 2022-11-16 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.374 Å) | | 主引用文献 | Functional metagenomic screening identifies an unexpected beta-glucuronidase.
Nat.Chem.Biol., 18, 2022
|
|
4CYS
 | | G6 mutant of PAS, arylsulfatase from Pseudomonas Aeruginosa, in complex with Phenylphosphonic acid | | 分子名称: | AMMONIUM ION, ARYLSULFATASE, CALCIUM ION, ... | | 著者 | Miton, C.M, Jonas, S, Mohammed, M.F, Fischer, G, Loo, B.v, Kintses, B, Hyvonen, M, Tokuriki, N, Hollfelder, F. | | 登録日 | 2014-04-14 | | 公開日 | 2015-04-29 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | | 主引用文献 | Evolutionary repurposing of a sulfatase: A new Michaelis complex leads to efficient transition state charge offset.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
|
|
4CXK
 | | G9 mutant of PAS, arylsulfatase from Pseudomonas Aeruginosa | | 分子名称: | ARYLSULFATASE, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Miton, C.M, Jonas, S, Mohammed, M.F, Fischer, G, Loo, B.v, Kintses, B, Hyvonen, M, Tokuriki, N, Hollfelder, F. | | 登録日 | 2014-04-07 | | 公開日 | 2015-04-22 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | | 主引用文献 | Evolutionary repurposing of a sulfatase: A new Michaelis complex leads to efficient transition state charge offset.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
|
|
4CYR
 | | G4 mutant of PAS, arylsulfatase from Pseudomonas Aeruginosa | | 分子名称: | ARYLSULFATASE, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Miton, C.M, Jonas, S, Mohammed, M.F, Fischer, G, Loo, B.v, Kintses, B, Hyvonen, M, Tokuriki, N, Hollfelder, F. | | 登録日 | 2014-04-14 | | 公開日 | 2015-04-29 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | | 主引用文献 | Evolutionary repurposing of a sulfatase: A new Michaelis complex leads to efficient transition state charge offset.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
|
|
2VQR
 | | Crystal structure of a phosphonate monoester hydrolase from rhizobium leguminosarum: a new member of the alkaline phosphatase superfamily | | 分子名称: | ACETATE ION, CALCIUM ION, MANGANESE (II) ION, ... | | 著者 | Jonas, S, Hyvonen, M, Hollfelder, F. | | 登録日 | 2008-03-18 | | 公開日 | 2008-09-30 | | 最終更新日 | 2019-04-24 | | 実験手法 | X-RAY DIFFRACTION (1.42 Å) | | 主引用文献 | A New Member of the Alkaline Phosphatase Superfamily with a Formylglycine Nucleophile: Structural and Kinetic Characterisation of a Phosphonate Monoester Hydrolase/Phosphodiesterase from Rhizobium Leguminosarum.
J.Mol.Biol., 384, 2008
|
|
7JIZ
 | |
