7VBM
 
 | | The mouse nucleosome structure containing H3mm18 aided by PL2-6 scFv | | 分子名称: | DNA (126-MER), Histone H2A type 1-B, Histone H2B type 3-A, ... | | 著者 | Hirai, S, Takizawa, Y, Kujirai, T, Kurumizaka, H. | | 登録日 | 2021-08-31 | | 公開日 | 2022-01-19 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Unusual nucleosome formation and transcriptome influence by the histone H3mm18 variant.
Nucleic Acids Res., 50, 2022
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7DBH
 | | The mouse nucleosome structure containing H3mm18 | | 分子名称: | DNA (126-MER), Histone H2A type 1-B, Histone H2B type 3-A, ... | | 著者 | Hirai, S, Takizawa, Y, Kujirai, T, Kurumizaka, H. | | 登録日 | 2020-10-20 | | 公開日 | 2022-01-19 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Unusual nucleosome formation and transcriptome influence by the histone H3mm18 variant.
Nucleic Acids Res., 50, 2022
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7WLR
 | | Cryo-EM structure of the nucleosome containing Komagataella pastoris histones | | 分子名称: | DNA (145-MER), Histone H2A, Histone H2B, ... | | 著者 | Fukushima, Y, Hatazawa, S, Hirai, S, Kujirai, T, Takizawa, Y, Kurumizaka, H. | | 登録日 | 2022-01-13 | | 公開日 | 2022-07-13 | | 最終更新日 | 2024-06-26 | | 実験手法 | ELECTRON MICROSCOPY (3.54 Å) | | 主引用文献 | Structural and biochemical analyses of the nucleosome containing Komagataella pastoris histones.
J.Biochem., 172, 2022
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7C0M
 | | Human cGAS-nucleosome complex | | 分子名称: | Cyclic GMP-AMP synthase, DNA (145-MER), Histone H2A type 1-B/E, ... | | 著者 | Kujirai, T, Zierhut, C, Takizawa, Y, Kim, R, Negishi, L, Uruma, N, Hirai, S, Funabiki, H, Kurumizaka, H. | | 登録日 | 2020-05-01 | | 公開日 | 2020-09-16 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Structural basis for the inhibition of cGAS by nucleosomes.
Science, 370, 2020
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8YBK
 | | Cryo-EM structure of the human nucleosome containing the H3.1 E97K mutant | | 分子名称: | DNA (145-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | | 著者 | Kimura, T, Hirai, S, Kujirai, T, Ogasawara, M, Takizawa, Y, Kurumizaka, H. | | 登録日 | 2024-02-14 | | 公開日 | 2024-07-24 | | 最終更新日 | 2024-09-11 | | 実験手法 | ELECTRON MICROSCOPY (2.69 Å) | | 主引用文献 | Cryo-EM structure and biochemical analyses of the nucleosome containing the cancer-associated histone H3 mutation E97K.
Genes Cells, 29, 2024
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8YBJ
 | | Cryo-EM structure of human nucleosome core particle composed of the Widom 601 DNA sequence | | 分子名称: | DNA (145-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | | 著者 | Kimura, T, Hirai, S, Kujirai, T, Ogasawara, M, Takizawa, Y, Kurumizaka, H. | | 登録日 | 2024-02-14 | | 公開日 | 2024-07-24 | | 最終更新日 | 2024-09-11 | | 実験手法 | ELECTRON MICROSCOPY (2.38 Å) | | 主引用文献 | Cryo-EM structure and biochemical analyses of the nucleosome containing the cancer-associated histone H3 mutation E97K.
Genes Cells, 29, 2024
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8KB5
 | | Cryo-EM structure of the human nucleosome containing H3.8 | | 分子名称: | DNA (145-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ... | | 著者 | Hirai, H, Kujirai, T, Takizawa, Y, Kurumizaka, H. | | 登録日 | 2023-08-03 | | 公開日 | 2023-10-18 | | 最終更新日 | 2023-12-27 | | 実験手法 | ELECTRON MICROSCOPY (2.26133 Å) | | 主引用文献 | Cryo-EM and biochemical analyses of the nucleosome containing the human histone H3 variant H3.8.
J.Biochem., 174, 2023
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3I5N
 | | Crystal structure of c-Met with triazolopyridazine inhibitor 13 | | 分子名称: | 7-methoxy-N-[(6-phenyl[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl]-1,5-naphthyridin-4-amine, Hepatocyte growth factor receptor | | 著者 | Bellon, S.F, Whittington, D.A, Long, A.M, Boezio, A.A. | | 登録日 | 2009-07-06 | | 公開日 | 2010-01-12 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Discovery and optimization of potent and selective triazolopyridazine series of c-Met inhibitors
Bioorg.Med.Chem.Lett., 19, 2009
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5EYC
 | | Crystal structure of c-Met in complex with naphthyridinone inhibitor 5 | | 分子名称: | 6-[(1~{R})-1-[8-fluoranyl-6-(3-methyl-1,2-oxazol-5-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl]ethyl]-1,6-naphthyridin-5-one, Hepatocyte growth factor receptor | | 著者 | Whittington, D.A, Long, A.M. | | 登録日 | 2015-11-24 | | 公開日 | 2016-02-10 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Discovery of (R)-6-(1-(8-Fluoro-6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)ethyl)-3-(2-methoxyethoxy)-1,6-naphthyridin-5(6H)-one (AMG 337), a Potent and Selective Inhibitor of MET with High Unbound Target Coverage and Robust In Vivo Antitumor Activity.
J.Med.Chem., 59, 2016
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5EYD
 | | Crystal structure of c-Met in complex with AMG 337 | | 分子名称: | 6-[(1~{R})-1-[8-fluoranyl-6-(1-methylpyrazol-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl]ethyl]-3-(2-methoxyethoxy)-1,6-naphthyridin-5-one, Hepatocyte growth factor receptor | | 著者 | Whittington, D.A, Long, A.M. | | 登録日 | 2015-11-24 | | 公開日 | 2016-02-10 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Discovery of (R)-6-(1-(8-Fluoro-6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)ethyl)-3-(2-methoxyethoxy)-1,6-naphthyridin-5(6H)-one (AMG 337), a Potent and Selective Inhibitor of MET with High Unbound Target Coverage and Robust In Vivo Antitumor Activity.
J.Med.Chem., 59, 2016
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3CCN
 | | X-ray structure of c-Met with triazolopyridazine inhibitor. | | 分子名称: | 4-[(6-phenyl[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl]phenol, Hepatocyte growth factor receptor | | 著者 | Abrecht, B.K, Harmange, J.-C, Bauer, D, Dussault, I, long, A, Bellon, S.F. | | 登録日 | 2008-02-26 | | 公開日 | 2008-04-29 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Discovery and Optimization of Triazolopyridazines as Potent and Selective Inhibitors of the c-Met Kinase.
J.Med.Chem., 51, 2008
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3CD8
 | | X-ray Structure of c-Met with triazolopyridazine Inhibitor. | | 分子名称: | 7-methoxy-4-[(6-phenyl[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methoxy]quinoline, Hepatocyte growth factor receptor | | 著者 | Bellon, S.F, Albrecht, B.K, Harmange, J.-C, Bauer, D, Choquette, D, Dussault, I. | | 登録日 | 2008-02-26 | | 公開日 | 2008-04-29 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Discovery and Optimization of Triazolopyridazines as Potent and Selective Inhibitors of the c-Met Kinase.
J.Med.Chem., 51, 2008
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7XJB
 | | Rat-COMT, opicapone,SAM and Mg bond | | 分子名称: | CHLORIDE ION, Catechol O-methyltransferase, MAGNESIUM ION, ... | | 著者 | Takebe, K, Iijima, H, Suzuki, M, Kuwada-Kusunose, T. | | 登録日 | 2022-04-15 | | 公開日 | 2023-05-31 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structural and Computational Analyses of the Unique Interactions of Opicapone in the Binding Pocket of Catechol O -Methyltransferase: A Crystallographic Study and Fragment Molecular Orbital Analyses.
J.Chem.Inf.Model., 63, 2023
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7XGI
 | | COMT SAH Mg opicapone complex | | 分子名称: | Catechol O-methyltransferase, MAGNESIUM ION, Opicapone, ... | | 著者 | Takebe, K, Kuwada-Kusunose, T, Suzuki, M, Iijima, H. | | 登録日 | 2022-04-04 | | 公開日 | 2023-04-12 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural and Computational Analyses of the Unique Interactions of Opicapone in the Binding Pocket of Catechol O -Methyltransferase: A Crystallographic Study and Fragment Molecular Orbital Analyses.
J.Chem.Inf.Model., 63, 2023
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