7C0M

Human cGAS-nucleosome complex

Summary for 7C0M

• Entry DOI: 10.2210/pdb7c0m/pdb
• EMDB information: 30267
• Descriptor: Histone H3.1, Histone H4, Histone H2A type 1-B/E, ... (8 entities in total)
• Functional Keywords: complex, chromatin, ntase, innate immunity, immunity, nucleosome, cgas, dna binding protein, dna binding protein-dna complex, dna binding protein/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 22
• Total formula weight: 492271.24

Authors

Kujirai, T.,Zierhut, C.,Takizawa, Y.,Kim, R.,Negishi, L.,Uruma, N.,Hirai, S.,Funabiki, H.,Kurumizaka, H. (deposition date: 2020-05-01, release date: 2020-09-16, Last modification date: 2024-03-27)

• Primary citation: Kujirai, T.,Zierhut, C.,Takizawa, Y.,Kim, R.,Negishi, L.,Uruma, N.,Hirai, S.,Funabiki, H.,Kurumizaka, H.; Structural basis for the inhibition of cGAS by nucleosomes.; Science, 370:455-458, 2020; PubMed: 32912999; DOI: 10.1126/science.abd0237

Experimental method

ELECTRON MICROSCOPY (3.9 Å)