7C0M
Human cGAS-nucleosome complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, E, L, P (A, E, a, e) | Histone H3.1 | polymer | 139 | 15719.4 | 4 | UniProt (P68431) Pfam (PF00125) | Homo sapiens (Human) | Histone H3/a,Histone H3/b,Histone H3/c,Histone H3/d,Histone H3/f,Histone H3/h,Histone H3/i,Histone H3/j,Histone H3/k,Histone H3/l |
| 2 | B, F, M, Q (B, F, b, f) | Histone H4 | polymer | 106 | 11676.7 | 4 | UniProt (P62805) Pfam (PF15511) | Homo sapiens (Human) | |
| 3 | C, G, N, R (C, G, c, g) | Histone H2A type 1-B/E | polymer | 133 | 14447.8 | 4 | UniProt (P04908) Pfam (PF00125) Pfam (PF16211) | Homo sapiens (Human) | Histone H2A.2,Histone H2A/a,Histone H2A/m |
| 4 | D, H, O, S (D, H, d, h) | Histone H2B type 1-J | polymer | 129 | 14217.5 | 4 | UniProt (P06899) Pfam (PF00125) | Homo sapiens (Human) | Histone H2B.1,Histone H2B.r,H2B/r |
| 5 | I, T (I, i) | DNA (145-MER) | polymer | 145 | 44520.4 | 2 | synthetic construct | ||
| 6 | J, U (J, j) | DNA (145-MER) | polymer | 145 | 44991.7 | 2 | synthetic construct | ||
| 7 | K, V (K, k) | Cyclic GMP-AMP synthase | polymer | 380 | 44435.2 | 2 | UniProt (Q8N884) Pfam (PF03281) Pfam (PF20266) | Homo sapiens (Human) | h-cGAS,2'3'-cGAMP synthase,Mab-21 domain-containing protein 1 |
| 8 | W, X (K, k) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) |
Sequence modifications
A, E, a, e: 1 - 135 (UniProt: P68431)
B, F, b, f: 1 - 102 (UniProt: P62805)
C, G, c, g: 1 - 129 (UniProt: P04908)
D, H, d, h: 1 - 125 (UniProt: P06899)
K, k: 151 - 522 (UniProt: Q8N884)
| PDB | External Database | Details |
|---|---|---|
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| His -1 | - | expression tag |
| Met 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| His -1 | - | expression tag |
| Met 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| His -1 | - | expression tag |
| Met 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| His -1 | - | expression tag |
| Met 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 149 | - | expression tag |
| Ser 150 | - | expression tag |
| Glu 523 | - | expression tag |
| Asn 524 | - | expression tag |
| Leu 525 | - | expression tag |
| Tyr 526 | - | expression tag |
| Phe 527 | - | expression tag |
| Gln 528 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 22 |
| Total formula weight | 492140.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 130.8 | |
| All* | Total formula weight | 492271.2 |
