7C0M

Human cGAS-nucleosome complex

Functional Information from GO Data

Chain	GOid	namespace	contents
a	0000786	cellular_component	nucleosome
a	0003677	molecular_function	DNA binding
a	0005515	molecular_function	protein binding
a	0005576	cellular_component	extracellular region
a	0005634	cellular_component	nucleus
a	0005654	cellular_component	nucleoplasm
a	0005694	cellular_component	chromosome
a	0006325	biological_process	chromatin organization
a	0006334	biological_process	nucleosome assembly
a	0010467	biological_process	gene expression
a	0016020	cellular_component	membrane
a	0030527	molecular_function	structural constituent of chromatin
a	0032200	biological_process	telomere organization
a	0032991	cellular_component	protein-containing complex
a	0040029	biological_process	epigenetic regulation of gene expression
a	0043229	cellular_component	intracellular organelle
a	0045296	molecular_function	cadherin binding
a	0046982	molecular_function	protein heterodimerization activity
a	0070062	cellular_component	extracellular exosome
A	0000786	cellular_component	nucleosome
A	0003677	molecular_function	DNA binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005694	cellular_component	chromosome
A	0006325	biological_process	chromatin organization
A	0006334	biological_process	nucleosome assembly
A	0010467	biological_process	gene expression
A	0016020	cellular_component	membrane
A	0030527	molecular_function	structural constituent of chromatin
A	0032200	biological_process	telomere organization
A	0032991	cellular_component	protein-containing complex
A	0040029	biological_process	epigenetic regulation of gene expression
A	0043229	cellular_component	intracellular organelle
A	0045296	molecular_function	cadherin binding
A	0046982	molecular_function	protein heterodimerization activity
A	0070062	cellular_component	extracellular exosome
b	0000781	cellular_component	chromosome, telomeric region
b	0000786	cellular_component	nucleosome
b	0003677	molecular_function	DNA binding
b	0003723	molecular_function	RNA binding
b	0005515	molecular_function	protein binding
b	0005576	cellular_component	extracellular region
b	0005634	cellular_component	nucleus
b	0005654	cellular_component	nucleoplasm
b	0005694	cellular_component	chromosome
b	0006325	biological_process	chromatin organization
b	0006334	biological_process	nucleosome assembly
b	0016020	cellular_component	membrane
b	0030527	molecular_function	structural constituent of chromatin
b	0032200	biological_process	telomere organization
b	0032991	cellular_component	protein-containing complex
b	0043505	cellular_component	CENP-A containing nucleosome
b	0045653	biological_process	negative regulation of megakaryocyte differentiation
b	0046982	molecular_function	protein heterodimerization activity
b	0061644	biological_process	protein localization to CENP-A containing chromatin
b	0070062	cellular_component	extracellular exosome
B	0000781	cellular_component	chromosome, telomeric region
B	0000786	cellular_component	nucleosome
B	0003677	molecular_function	DNA binding
B	0003723	molecular_function	RNA binding
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005694	cellular_component	chromosome
B	0006325	biological_process	chromatin organization
B	0006334	biological_process	nucleosome assembly
B	0016020	cellular_component	membrane
B	0030527	molecular_function	structural constituent of chromatin
B	0032200	biological_process	telomere organization
B	0032991	cellular_component	protein-containing complex
B	0043505	cellular_component	CENP-A containing nucleosome
B	0045653	biological_process	negative regulation of megakaryocyte differentiation
B	0046982	molecular_function	protein heterodimerization activity
B	0061644	biological_process	protein localization to CENP-A containing chromatin
B	0070062	cellular_component	extracellular exosome
c	0000786	cellular_component	nucleosome
c	0003677	molecular_function	DNA binding
c	0005515	molecular_function	protein binding
c	0005634	cellular_component	nucleus
c	0005694	cellular_component	chromosome
c	0006325	biological_process	chromatin organization
c	0008285	biological_process	negative regulation of cell population proliferation
c	0030527	molecular_function	structural constituent of chromatin
c	0031492	molecular_function	nucleosomal DNA binding
c	0031507	biological_process	heterochromatin formation
c	0043229	cellular_component	intracellular organelle
c	0043505	cellular_component	CENP-A containing nucleosome
c	0046982	molecular_function	protein heterodimerization activity
c	0061644	biological_process	protein localization to CENP-A containing chromatin
c	0070062	cellular_component	extracellular exosome
C	0000786	cellular_component	nucleosome
C	0003677	molecular_function	DNA binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005694	cellular_component	chromosome
C	0006325	biological_process	chromatin organization
C	0008285	biological_process	negative regulation of cell population proliferation
C	0030527	molecular_function	structural constituent of chromatin
C	0031492	molecular_function	nucleosomal DNA binding
C	0031507	biological_process	heterochromatin formation
C	0043229	cellular_component	intracellular organelle
C	0043505	cellular_component	CENP-A containing nucleosome
C	0046982	molecular_function	protein heterodimerization activity
C	0061644	biological_process	protein localization to CENP-A containing chromatin
C	0070062	cellular_component	extracellular exosome
d	0000786	cellular_component	nucleosome
d	0001530	molecular_function	lipopolysaccharide binding
d	0002227	biological_process	innate immune response in mucosa
d	0003677	molecular_function	DNA binding
d	0005515	molecular_function	protein binding
d	0005615	cellular_component	extracellular space
d	0005634	cellular_component	nucleus
d	0005654	cellular_component	nucleoplasm
d	0005694	cellular_component	chromosome
d	0005829	cellular_component	cytosol
d	0005886	cellular_component	plasma membrane
d	0006325	biological_process	chromatin organization
d	0006334	biological_process	nucleosome assembly
d	0010804	biological_process	negative regulation of tumor necrosis factor-mediated signaling pathway
d	0019731	biological_process	antibacterial humoral response
d	0030527	molecular_function	structural constituent of chromatin
d	0031640	biological_process	killing of cells of another organism
d	0042742	biological_process	defense response to bacterium
d	0043229	cellular_component	intracellular organelle
d	0043505	cellular_component	CENP-A containing nucleosome
d	0046982	molecular_function	protein heterodimerization activity
d	0050829	biological_process	defense response to Gram-negative bacterium
d	0050830	biological_process	defense response to Gram-positive bacterium
d	0061644	biological_process	protein localization to CENP-A containing chromatin
d	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
D	0000786	cellular_component	nucleosome
D	0001530	molecular_function	lipopolysaccharide binding
D	0002227	biological_process	innate immune response in mucosa
D	0003677	molecular_function	DNA binding
D	0005515	molecular_function	protein binding
D	0005615	cellular_component	extracellular space
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005694	cellular_component	chromosome
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0006325	biological_process	chromatin organization
D	0006334	biological_process	nucleosome assembly
D	0010804	biological_process	negative regulation of tumor necrosis factor-mediated signaling pathway
D	0019731	biological_process	antibacterial humoral response
D	0030527	molecular_function	structural constituent of chromatin
D	0031640	biological_process	killing of cells of another organism
D	0042742	biological_process	defense response to bacterium
D	0043229	cellular_component	intracellular organelle
D	0043505	cellular_component	CENP-A containing nucleosome
D	0046982	molecular_function	protein heterodimerization activity
D	0050829	biological_process	defense response to Gram-negative bacterium
D	0050830	biological_process	defense response to Gram-positive bacterium
D	0061644	biological_process	protein localization to CENP-A containing chromatin
D	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
e	0000786	cellular_component	nucleosome
e	0003677	molecular_function	DNA binding
e	0005515	molecular_function	protein binding
e	0005576	cellular_component	extracellular region
e	0005634	cellular_component	nucleus
e	0005654	cellular_component	nucleoplasm
e	0005694	cellular_component	chromosome
e	0006325	biological_process	chromatin organization
e	0006334	biological_process	nucleosome assembly
e	0010467	biological_process	gene expression
e	0016020	cellular_component	membrane
e	0030527	molecular_function	structural constituent of chromatin
e	0032200	biological_process	telomere organization
e	0032991	cellular_component	protein-containing complex
e	0040029	biological_process	epigenetic regulation of gene expression
e	0043229	cellular_component	intracellular organelle
e	0045296	molecular_function	cadherin binding
e	0046982	molecular_function	protein heterodimerization activity
e	0070062	cellular_component	extracellular exosome
E	0000786	cellular_component	nucleosome
E	0003677	molecular_function	DNA binding
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005694	cellular_component	chromosome
E	0006325	biological_process	chromatin organization
E	0006334	biological_process	nucleosome assembly
E	0010467	biological_process	gene expression
E	0016020	cellular_component	membrane
E	0030527	molecular_function	structural constituent of chromatin
E	0032200	biological_process	telomere organization
E	0032991	cellular_component	protein-containing complex
E	0040029	biological_process	epigenetic regulation of gene expression
E	0043229	cellular_component	intracellular organelle
E	0045296	molecular_function	cadherin binding
E	0046982	molecular_function	protein heterodimerization activity
E	0070062	cellular_component	extracellular exosome
f	0000781	cellular_component	chromosome, telomeric region
f	0000786	cellular_component	nucleosome
f	0003677	molecular_function	DNA binding
f	0003723	molecular_function	RNA binding
f	0005515	molecular_function	protein binding
f	0005576	cellular_component	extracellular region
f	0005634	cellular_component	nucleus
f	0005654	cellular_component	nucleoplasm
f	0005694	cellular_component	chromosome
f	0006325	biological_process	chromatin organization
f	0006334	biological_process	nucleosome assembly
f	0016020	cellular_component	membrane
f	0030527	molecular_function	structural constituent of chromatin
f	0032200	biological_process	telomere organization
f	0032991	cellular_component	protein-containing complex
f	0043505	cellular_component	CENP-A containing nucleosome
f	0045653	biological_process	negative regulation of megakaryocyte differentiation
f	0046982	molecular_function	protein heterodimerization activity
f	0061644	biological_process	protein localization to CENP-A containing chromatin
f	0070062	cellular_component	extracellular exosome
F	0000781	cellular_component	chromosome, telomeric region
F	0000786	cellular_component	nucleosome
F	0003677	molecular_function	DNA binding
F	0003723	molecular_function	RNA binding
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005694	cellular_component	chromosome
F	0006325	biological_process	chromatin organization
F	0006334	biological_process	nucleosome assembly
F	0016020	cellular_component	membrane
F	0030527	molecular_function	structural constituent of chromatin
F	0032200	biological_process	telomere organization
F	0032991	cellular_component	protein-containing complex
F	0043505	cellular_component	CENP-A containing nucleosome
F	0045653	biological_process	negative regulation of megakaryocyte differentiation
F	0046982	molecular_function	protein heterodimerization activity
F	0061644	biological_process	protein localization to CENP-A containing chromatin
F	0070062	cellular_component	extracellular exosome
g	0000786	cellular_component	nucleosome
g	0003677	molecular_function	DNA binding
g	0005515	molecular_function	protein binding
g	0005634	cellular_component	nucleus
g	0005694	cellular_component	chromosome
g	0006325	biological_process	chromatin organization
g	0008285	biological_process	negative regulation of cell population proliferation
g	0030527	molecular_function	structural constituent of chromatin
g	0031492	molecular_function	nucleosomal DNA binding
g	0031507	biological_process	heterochromatin formation
g	0043229	cellular_component	intracellular organelle
g	0043505	cellular_component	CENP-A containing nucleosome
g	0046982	molecular_function	protein heterodimerization activity
g	0061644	biological_process	protein localization to CENP-A containing chromatin
g	0070062	cellular_component	extracellular exosome
G	0000786	cellular_component	nucleosome
G	0003677	molecular_function	DNA binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005694	cellular_component	chromosome
G	0006325	biological_process	chromatin organization
G	0008285	biological_process	negative regulation of cell population proliferation
G	0030527	molecular_function	structural constituent of chromatin
G	0031492	molecular_function	nucleosomal DNA binding
G	0031507	biological_process	heterochromatin formation
G	0043229	cellular_component	intracellular organelle
G	0043505	cellular_component	CENP-A containing nucleosome
G	0046982	molecular_function	protein heterodimerization activity
G	0061644	biological_process	protein localization to CENP-A containing chromatin
G	0070062	cellular_component	extracellular exosome
h	0000786	cellular_component	nucleosome
h	0001530	molecular_function	lipopolysaccharide binding
h	0002227	biological_process	innate immune response in mucosa
h	0003677	molecular_function	DNA binding
h	0005515	molecular_function	protein binding
h	0005615	cellular_component	extracellular space
h	0005634	cellular_component	nucleus
h	0005654	cellular_component	nucleoplasm
h	0005694	cellular_component	chromosome
h	0005829	cellular_component	cytosol
h	0005886	cellular_component	plasma membrane
h	0006325	biological_process	chromatin organization
h	0006334	biological_process	nucleosome assembly
h	0010804	biological_process	negative regulation of tumor necrosis factor-mediated signaling pathway
h	0019731	biological_process	antibacterial humoral response
h	0030527	molecular_function	structural constituent of chromatin
h	0031640	biological_process	killing of cells of another organism
h	0042742	biological_process	defense response to bacterium
h	0043229	cellular_component	intracellular organelle
h	0043505	cellular_component	CENP-A containing nucleosome
h	0046982	molecular_function	protein heterodimerization activity
h	0050829	biological_process	defense response to Gram-negative bacterium
h	0050830	biological_process	defense response to Gram-positive bacterium
h	0061644	biological_process	protein localization to CENP-A containing chromatin
h	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
H	0000786	cellular_component	nucleosome
H	0001530	molecular_function	lipopolysaccharide binding
H	0002227	biological_process	innate immune response in mucosa
H	0003677	molecular_function	DNA binding
H	0005515	molecular_function	protein binding
H	0005615	cellular_component	extracellular space
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005694	cellular_component	chromosome
H	0005829	cellular_component	cytosol
H	0005886	cellular_component	plasma membrane
H	0006325	biological_process	chromatin organization
H	0006334	biological_process	nucleosome assembly
H	0010804	biological_process	negative regulation of tumor necrosis factor-mediated signaling pathway
H	0019731	biological_process	antibacterial humoral response
H	0030527	molecular_function	structural constituent of chromatin
H	0031640	biological_process	killing of cells of another organism
H	0042742	biological_process	defense response to bacterium
H	0043229	cellular_component	intracellular organelle
H	0043505	cellular_component	CENP-A containing nucleosome
H	0046982	molecular_function	protein heterodimerization activity
H	0050829	biological_process	defense response to Gram-negative bacterium
H	0050830	biological_process	defense response to Gram-positive bacterium
H	0061644	biological_process	protein localization to CENP-A containing chromatin
H	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN K 601

Chain	Residue
K	HIS390
K	CYS396
K	CYS397
K	CYS404

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN k 601

Chain	Residue
k	HIS390
k	CYS396
k	CYS397
k	CYS404

---

Functional Information from PROSITE/UniProt

site_id	PS00046
Number of Residues	7
Details	HISTONE_H2A Histone H2A signature. AGLqFPV

Chain	Residue	Details
C	ALA21-VAL27

---

site_id	PS00047
Number of Residues	5
Details	HISTONE_H4 Histone H4 signature. GAKRH

Chain	Residue	Details
B	GLY14-HIS18

---

site_id	PS00322
Number of Residues	7
Details	HISTONE_H3_1 Histone H3 signature 1. KAPRKQL

Chain	Residue	Details
A	LYS14-LEU20

---

site_id	PS00357
Number of Residues	23
Details	HISTONE_H2B Histone H2B signature. REIQTavRlLLpGELaKHAVSEG

Chain	Residue	Details
D	ARG92-GLY114

---

site_id	PS00959
Number of Residues	9
Details	HISTONE_H3_2 Histone H3 signature 2. PFqRLVREI

Chain	Residue	Details
A	PRO66-ILE74

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q8C6L5

Chain	Residue	Details
K	THR211
k	THR211
d	PRO1
h	PRO1

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:30007416, ECO:0007744|PDB:6CTA

Chain	Residue	Details
K	SER213
K	SER380
K	LYS414
k	SER213
k	SER380
k	LYS414

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:30007416, ECO:0000305|PubMed:23722159, ECO:0000305|PubMed:26229115, ECO:0007744|PDB:6CT9, ECO:0007744|PDB:6CTA

Chain	Residue	Details
K	GLU225
H	LYS11
H	LYS15
H	LYS16
H	LYS20
H	LYS23
H	LYS43
H	LYS85
d	LYS5
d	LYS11
d	LYS15
K	ASP227
d	LYS16
d	LYS20
d	LYS23
d	LYS43
d	LYS85
h	LYS5
h	LYS11
h	LYS15
h	LYS16
h	LYS20
k	GLU225
h	LYS23
h	LYS43
h	LYS85
k	ASP227
D	LYS20
D	LYS23
D	LYS43
D	LYS85
H	LYS5

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:30007416, ECO:0007744|PDB:6CT9, ECO:0007744|PDB:6CTA

Chain	Residue	Details
K	ASP319
k	ASP319
d	SER6
h	SER6
c	LYS9
c	LYS95
g	LYS9
g	LYS95

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:24462292, ECO:0000269|PubMed:31113940, ECO:0007744|PDB:4O67, ECO:0007744|PDB:6MJX

Chain	Residue	Details
K	LYS362
f	LYS8
f	LYS16
f	LYS44
K	ARG376
k	LYS362
k	ARG376
F	LYS16
F	LYS44
b	LYS8
b	LYS16
b	LYS44

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:23707061, ECO:0000269|PubMed:24332030, ECO:0000269|PubMed:24462292, ECO:0000269|PubMed:28934246, ECO:0000269|PubMed:28940468, ECO:0000269|PubMed:30007416, ECO:0000269|PubMed:31113940, ECO:0000269|PubMed:31142647, ECO:0000269|PubMed:32911482, ECO:0000269|PubMed:32912999, ECO:0007744|PDB:5V8O, ECO:0007744|PDB:5VDO, ECO:0007744|PDB:5VDP, ECO:0007744|PDB:5VDQ, ECO:0007744|PDB:5VDR, ECO:0007744|PDB:5VDS, ECO:0007744|PDB:5VDT, ECO:0007744|PDB:5VDU, ECO:0007744|PDB:5VDV, ECO:0007744|PDB:5VDW, ECO:0007744|PDB:6CT9, ECO:0007744|PDB:6CTA, ECO:0007744|PDB:6EDB, ECO:0007744|PDB:6EDC, ECO:0007744|PDB:6MJU, ECO:0007744|PDB:6MJW, ECO:0007744|PDB:6MJX, ECO:0007744|PDB:6NAO, ECO:0007744|PDB:6NFG, ECO:0007744|PDB:6NFO, ECO:0007744|PDB:6Y5D, ECO:0007744|PDB:6Y5E, ECO:0007744|PDB:7C0M

Chain	Residue	Details
K	HIS390
b	LYS31
b	LYS77
b	LYS91
f	LYS12
f	LYS31
f	LYS77
f	LYS91
k	HIS390
d	SER14
h	SER14
F	LYS12
F	LYS31
F	LYS77
F	LYS91
b	LYS12

---

site_id	SWS_FT_FI7
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:23707061, ECO:0000269|PubMed:24332030, ECO:0000269|PubMed:24462292, ECO:0000269|PubMed:28934246, ECO:0000269|PubMed:28940468, ECO:0000269|PubMed:30007416, ECO:0000269|PubMed:31113940, ECO:0000269|PubMed:31142647, ECO:0000269|PubMed:32459092, ECO:0000269|PubMed:32911482, ECO:0000269|PubMed:32912999, ECO:0007744|PDB:5V8O, ECO:0007744|PDB:5VDO, ECO:0007744|PDB:5VDP, ECO:0007744|PDB:5VDQ, ECO:0007744|PDB:5VDR, ECO:0007744|PDB:5VDS, ECO:0007744|PDB:5VDT, ECO:0007744|PDB:5VDU, ECO:0007744|PDB:5VDV, ECO:0007744|PDB:5VDW, ECO:0007744|PDB:6CT9, ECO:0007744|PDB:6CTA, ECO:0007744|PDB:6EDB, ECO:0007744|PDB:6EDC, ECO:0007744|PDB:6LRC, ECO:0007744|PDB:6MJU, ECO:0007744|PDB:6MJW, ECO:0007744|PDB:6MJX, ECO:0007744|PDB:6NAO, ECO:0007744|PDB:6NFG, ECO:0007744|PDB:6NFO, ECO:0007744|PDB:6O47, ECO:0007744|PDB:6Y5D, ECO:0007744|PDB:6Y5E, ECO:0007744|PDB:7C0M

Chain	Residue	Details
K	CYS396
K	CYS397
K	CYS404
k	CYS396
k	CYS397
k	CYS404
g	LYS74
g	LYS75

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:30007416, ECO:0000305|PubMed:24462292, ECO:0007744|PDB:6CTA

Chain	Residue	Details
K	SER435
h	LYS34
h	LYS116
h	LYS120
k	SER435
D	LYS120
H	LYS34
H	LYS116
H	LYS120
d	LYS34
d	LYS116
d	LYS120

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	SITE: Cleavage; by CASP1 => ECO:0000269|PubMed:28314590

Chain	Residue	Details
K	ASP157
g	LYS118
g	LYS119
g	LYS125
k	ASP157
d	GLU35
h	GLU35
G	LYS119
G	LYS125
c	LYS118
c	LYS119
c	LYS125

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	SITE: Important for preferential detection of curved long DNA => ECO:0000269|PubMed:30007416

Chain	Residue	Details
K	LYS187
K	LEU195
k	LYS187
k	LEU195
a	LYS14
a	LYS56
e	LYS14
e	LYS56

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	SITE: Arginine-anchor => ECO:0000269|PubMed:32911482, ECO:0000269|PubMed:32912999, ECO:0000269|PubMed:33051594

Chain	Residue	Details
K	ARG255
k	ARG255
H	LYS46
H	LYS108
d	LYS46
d	LYS108
h	LYS46
h	LYS108

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	SITE: Cleavage; by CASP3 => ECO:0000269|PubMed:30878284

Chain	Residue	Details
K	ASP319
k	ASP319
d	LYS57
h	LYS57
a	LYS18
c	LYS119
e	LYS18
g	LYS119

---

site_id	SWS_FT_FI13
Number of Residues	2
Details	MOD_RES: PolyADP-ribosyl aspartic acid => ECO:0000269|PubMed:35460603

Chain	Residue	Details
K	ASP191
k	ASP191
d	ARG79
h	ARG79

---

site_id	SWS_FT_FI14
Number of Residues	4
Details	MOD_RES: (Microbial infection) Deamidated asparagine; by herpes simplex virus 1/HHV-1 UL37 => ECO:0000269|PubMed:30092200

Chain	Residue	Details
K	ASN210
K	ASN389
k	ASN210
k	ASN389
d	ARG86
d	ARG92
h	ARG86
h	ARG92

---

site_id	SWS_FT_FI15
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:33273464

Chain	Residue	Details
K	SER213
k	SER213
d	THR115
h	THR115
b	LYS91
f	LYS91

---

site_id	SWS_FT_FI16
Number of Residues	2
Details	MOD_RES: Phosphotyrosine; by BLK => ECO:0000269|PubMed:30356214

Chain	Residue	Details
K	TYR215
f	LYS20
f	LYS59
f	LYS79
k	TYR215
d	SER112
h	SER112
F	LYS59
F	LYS79
b	LYS20
b	LYS59
b	LYS79

---

site_id	SWS_FT_FI17
Number of Residues	2
Details	MOD_RES: 5-glutamyl polyglutamate => ECO:0000250|UniProtKB:Q8C6L5

Chain	Residue	Details
K	GLU286
k	GLU286
d	LYS5
h	LYS5

---

site_id	SWS_FT_FI18
Number of Residues	2
Details	MOD_RES: Phosphoserine; by CDK1 and PKB => ECO:0000269|PubMed:26440888, ECO:0000269|PubMed:32351706, ECO:0000269|PubMed:33542149

Chain	Residue	Details
K	SER305
k	SER305
a	LYS37
H	LYS120
d	LYS120
h	LYS120

---

site_id	SWS_FT_FI19
Number of Residues	2
Details	MOD_RES: 5-glutamyl glutamate => ECO:0000250|UniProtKB:Q8C6L5

Chain	Residue	Details
K	GLU314
k	GLU314
d	LYS20
h	LYS20

---

site_id	SWS_FT_FI20
Number of Residues	6
Details	MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:30799039

Chain	Residue	Details
K	LYS384
K	LYS392
K	LYS394
k	LYS384
k	LYS392
k	LYS394

---

site_id	SWS_FT_FI21
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:30799039, ECO:0007744|PubMed:19608861

Chain	Residue	Details
K	LYS414
k	LYS414
a	LYS79
e	LYS79

---

site_id	SWS_FT_FI22
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:32474700

Chain	Residue	Details
K	SER434
K	SER435
k	SER434
k	SER435

---

site_id	SWS_FT_FI23
Number of Residues	4
Details	MOD_RES: (Microbial infection) Deamidated glutamine; by herpes simplex virus 1/HHV-1 UL37 => ECO:0000269|PubMed:30092200

Chain	Residue	Details
K	GLN451
K	GLN454
k	GLN451
k	GLN454

---

site_id	SWS_FT_FI24
Number of Residues	2
Details	MOD_RES: N6-methyllysine => ECO:0000269|PubMed:35210392

Chain	Residue	Details
K	LYS506
k	LYS506
a	THR107
e	THR107

---

site_id	SWS_FT_FI25
Number of Residues	4
Details	LIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:37802025

Chain	Residue	Details
K	CYS404
K	CYS405
k	CYS404
k	CYS405

---

site_id	SWS_FT_FI26
Number of Residues	2
Details	LIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:35438208

Chain	Residue	Details
K	CYS474
k	CYS474
a	LYS122
e	LYS122

---

site_id	SWS_FT_FI27
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:28273161

Chain	Residue	Details
K	LYS173
k	LYS173
a	LYS18
e	LYS18

---

site_id	SWS_FT_FI28
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269|PubMed:27637147

Chain	Residue	Details
K	LYS479
k	LYS479

---

site_id	SWS_FT_FI29
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000269|PubMed:27637147

Chain	Residue	Details
K	LYS231
k	LYS231

---

site_id	SWS_FT_FI30
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:27637147

Chain	Residue	Details
K	LYS285
k	LYS285

---

site_id	SWS_FT_FI31
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:Q8C6L5

Chain	Residue	Details
K	LYS347
k	LYS347

---

site_id	SWS_FT_FI32
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269|PubMed:28273161

Chain	Residue	Details
K	LYS384
k	LYS384

---

site_id	SWS_FT_FI33
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000250|UniProtKB:Q8C6L5

Chain	Residue	Details
K	LYS394
k	LYS394

---

site_id	SWS_FT_FI34
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:35503863

Chain	Residue	Details
K	LYS411
k	LYS411

---

site_id	SWS_FT_FI35
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:27666593

Chain	Residue	Details
K	LYS414
k	LYS414

---