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8VFU
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BU of 8vfu by Molmil
The Fab Crystal Structure of the PAN IL-1 Family Inhibitor Antibody 3G5
分子名称: 3G5 Heavy Chain, 3G5 Light Chain
著者Fields, J.K, Sundberg, E.J.
登録日2023-12-22
公開日2024-02-21
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Antibodies targeting the shared cytokine receptor IL-1 receptor accessory protein invoke distinct mechanisms to block all cytokine signaling.
Cell Rep, 43, 2024
7LBL
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BU of 7lbl by Molmil
Structure of Human IgG1 Fc
分子名称: Ig gamma-1 chain C region, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose
著者Fields, J.K, Sundberg, E.J.
登録日2021-01-08
公開日2021-01-20
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.13 Å)
主引用文献Silent Antibodies: Generation of Hyperglycosylated FCs to Ablate Effector Functions
To Be Published
7LFN
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BU of 7lfn by Molmil
Structure of Hyperglycosylated Human IgG1 Fc (Fc267_329)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, IgG1 Fc (Fc267_329), alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Fields, J.K, Sundberg, E.J.
登録日2021-01-17
公開日2021-01-27
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Silent Antibodies: Generation of Hyperglycosylated FCs to Ablate Effector Functions
To Be Published
7LF9
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BU of 7lf9 by Molmil
Structure of Hyperglycosylated Human IgG1 Fc (Fc329)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, IgG1 Fc (Fc329), ...
著者Fields, J.K, Sundberg, E.J.
登録日2021-01-15
公開日2021-01-27
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Silent Antibodies: Generation of Hyperglycosylated FCs to Ablate Effector Functions
To Be Published
7LF5
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BU of 7lf5 by Molmil
Structure of Hyperglycosylated Human IgG1 Fc (Fc267)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, IgG1 Fc (Fc267), alpha-L-fucopyranose, ...
著者Fields, J.K, Sundberg, E.J.
登録日2021-01-15
公開日2021-01-27
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Silent Antibodies: Generation of Hyperglycosylated FCs to Ablate Effector Functions
To Be Published
8G6H
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BU of 8g6h by Molmil
H2BK120ub+H3K79me2-modified nucleosome ubiquitin position 6
分子名称: 601 DNA (185-MER), Histone H2A, Histone H2B 1.1, ...
著者Hicks, C.W, Wolberger, C.
登録日2023-02-15
公開日2024-02-21
実験手法ELECTRON MICROSCOPY (3.06 Å)
主引用文献Ubiquitinated H2B as gatekeeper of the nucleosome acidic patch
To Be Published
6E58
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BU of 6e58 by Molmil
Crystal structure of Streptococcus pyogenes endo-beta-N-acetylglucosaminidase (EndoS2)
分子名称: CALCIUM ION, Secreted Endo-beta-N-acetylglucosaminidase (EndoS)
著者Klontz, E.H, Trastoy, B, Gunther, S, Guerin, M.E, Sundberg, E.J.
登録日2018-07-19
公開日2019-02-06
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Molecular Basis of Broad SpectrumN-Glycan Specificity and Processing of Therapeutic IgG Monoclonal Antibodies by Endoglycosidase S2.
ACS Cent Sci, 5, 2019
8G6G
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BU of 8g6g by Molmil
H2BK120ub+H3K79me2-modified nucleosome ubiquitin position 5
分子名称: 601 DNA (185-MER), Histone H2A, Histone H2B 1.1, ...
著者Hicks, C.W, Wolberger, C.
登録日2023-02-15
公開日2024-02-21
実験手法ELECTRON MICROSCOPY (2.93 Å)
主引用文献Ubiquitinated H2B as gatekeeper of the nucleosome acidic patch
To Be Published
8G6Q
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BU of 8g6q by Molmil
H2AK119ub-modified nucleosome ubiquitin position 1
分子名称: 601 DNA (145-MER), Histone H2A, Histone H2B 1.1, ...
著者Hicks, C.W, Wolberger, C.
登録日2023-02-15
公開日2024-02-21
実験手法ELECTRON MICROSCOPY (3.41 Å)
主引用文献Ubiquitinated H2B as gatekeeper of the nucleosome acidic patch
To Be Published
8G6S
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BU of 8g6s by Molmil
H2AK119ub-modified nucleosome ubiquitin position 2
分子名称: 601 DNA (145-MER), Histone H2A, Histone H2B 1.1, ...
著者Hicks, C.W, Wolberger, C.
登録日2023-02-15
公開日2024-02-21
実験手法ELECTRON MICROSCOPY (3.47 Å)
主引用文献Ubiquitinated H2B as gatekeeper of the nucleosome acidic patch
To Be Published
6MDS
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BU of 6mds by Molmil
Crystal structure of Streptococcus pyogenes endo-beta-N-acetylglucosaminidase (EndoS2) with complex biantennary glycan
分子名称: CALCIUM ION, Endo-beta-N-acetylglucosaminidase, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Klontz, E.H, Trastoy, B, Orwenyo, J, Wang, L.X, Guerin, M.E, Sundberg, E.J.
登録日2018-09-05
公開日2019-02-06
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Molecular Basis of Broad SpectrumN-Glycan Specificity and Processing of Therapeutic IgG Monoclonal Antibodies by Endoglycosidase S2.
ACS Cent Sci, 5, 2019
6MDV
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BU of 6mdv by Molmil
Crystal structure of Streptococcus pyogenes endo-beta-N-acetylglucosaminidase (EndoS2) with high-mannose glycan
分子名称: CALCIUM ION, Endo-beta-N-acetylglucosaminidase, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Klontz, E.H, Trastoy, B, Orwenyo, J, Wang, L.X, Guerin, M.E, Sundberg, E.J.
登録日2018-09-05
公開日2019-02-06
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Molecular Basis of Broad SpectrumN-Glycan Specificity and Processing of Therapeutic IgG Monoclonal Antibodies by Endoglycosidase S2.
ACS Cent Sci, 5, 2019
6O1C
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BU of 6o1c by Molmil
Alpha-L-fucosidase AlfC D200A mutant in complex with 4-nitrophenyl-a-L-fucopyranoside substrate
分子名称: 4-nitrophenyl 6-deoxy-alpha-L-galactopyranoside, AlfC
著者Klontz, E.H, Sundberg, E.J.
登録日2019-02-19
公開日2020-02-19
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structure and dynamics of an alpha-fucosidase reveal a mechanism for highly efficient IgG transfucosylation.
Nat Commun, 11, 2020
6O1A
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BU of 6o1a by Molmil
Alpha-L-fucosidase AlfC from Lactobacillus casei in complex with alpha-L-fucose product
分子名称: AlfC, beta-L-fucopyranose
著者Klontz, E.H, Sundberg, E.J.
登録日2019-02-18
公開日2020-02-19
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structure and dynamics of an alpha-fucosidase reveal a mechanism for highly efficient IgG transfucosylation.
Nat Commun, 11, 2020
6O1J
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BU of 6o1j by Molmil
Alpha-L-fucosidase AlfC fucosyltransferase mutant N243A
分子名称: AlfC, beta-L-fucopyranose
著者Klontz, E.H, Sundberg, E.J.
登録日2019-02-20
公開日2020-02-26
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure and dynamics of an alpha-fucosidase reveal a mechanism for highly efficient IgG transfucosylation.
Nat Commun, 11, 2020
6O18
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BU of 6o18 by Molmil
Unliganded alpha-L-fucosidase AlfC from Lactobacillus casei
分子名称: AlfC
著者Klontz, E.H, Sundberg, E.J.
登録日2019-02-18
公開日2020-02-19
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Structure and dynamics of an alpha-fucosidase reveal a mechanism for highly efficient IgG transfucosylation.
Nat Commun, 11, 2020
6O1I
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BU of 6o1i by Molmil
Alpha-L-fucosidase AlfC fucosyltransferase mutant E274A
分子名称: AlfC
著者Klontz, E.H, Sundberg, E.J.
登録日2019-02-20
公開日2020-02-26
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.55 Å)
主引用文献Structure and dynamics of an alpha-fucosidase reveal a mechanism for highly efficient IgG transfucosylation.
Nat Commun, 11, 2020
6OHE
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BU of 6ohe by Molmil
Alpha-L-fucosidase AlfC D200A in complex with Fuca(1,6)GlcNAc
分子名称: AlfC, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Klontz, E.H, Sundberg, E.J.
登録日2019-04-05
公開日2020-04-08
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.14 Å)
主引用文献Structure and dynamics of an alpha-fucosidase reveal a mechanism for highly efficient IgG transfucosylation.
Nat Commun, 11, 2020
8TTM
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BU of 8ttm by Molmil
IgG1 Fc Heterodimer combYSelect1
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Immunoglobulin gamma-1 heavy chain
著者Azzam, T, Du, J.J, Sundberg, E.J.
登録日2023-08-14
公開日2024-06-26
実験手法X-RAY DIFFRACTION (2.51 Å)
主引用文献Combinatorially restricted computational design of protein-protein interfaces to produce IgG heterodimers.
Sci Adv, 10, 2024
8TUD
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BU of 8tud by Molmil
IgG1 Fc Heterodimer combYSelect2
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Immunoglobulin gamma-1 heavy chain
著者Azzam, T, Du, J.J, Sundberg, E.J.
登録日2023-08-16
公開日2024-06-26
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Combinatorially restricted computational design of protein-protein interfaces to produce IgG heterodimers.
Sci Adv, 10, 2024
5VAW
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BU of 5vaw by Molmil
Fusion of Maltose-binding Protein and PilA from Acinetobacter baumannii AB5075
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, GLUTAMIC ACID, LYSINE, ...
著者Piepenbrink, K.H, Sundberg, E.J.
登録日2017-03-28
公開日2018-03-28
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.69 Å)
主引用文献The structure of PilA fromAcinetobacter baumanniiAB5075 suggests a mechanism for functional specialization inAcinetobactertype IV pili.
J. Biol. Chem., 294, 2019

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件を2024-07-10に公開中

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