7OA4
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![BU of 7oa4 by Molmil](/molmil-images/mine/7oa4) | Crystal structure of the N-terminal endonuclease domain of La Crosse virus L-protein bound to compound L-742,001 | 分子名称: | (2Z)-4-[1-benzyl-4-(4-chlorobenzyl)piperidin-4-yl]-2-hydroxy-4-oxobut-2-enoic acid, FORMIC ACID, MANGANESE (II) ION, ... | 著者 | Feracci, M, Hernandez, S, Vincentelli, R, Ferron, F, Reguera, J, Canard, B, Alvarez, K. | 登録日 | 2021-04-19 | 公開日 | 2022-08-03 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Crystal structure of the N-terminal endonuclease domain of La Crosse virus L-protein bound to compound L-742,001 To Be Published
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7PLR
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![BU of 7plr by Molmil](/molmil-images/mine/7plr) | Crystal structure of the N-terminal endonuclease domain of La Crosse virus L-protein bound to compound Baloxavir | 分子名称: | Baloxavir acid, FORMIC ACID, GLYCEROL, ... | 著者 | Feracci, M, Hernandez, S, Vincentelli, R, Ferron, F, Reguera, J, Canard, B, Alvarez, K. | 登録日 | 2021-09-01 | 公開日 | 2022-09-14 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.64 Å) | 主引用文献 | Crystal structure of the N-terminal endonuclease domain of La Crosse virus L-protein bound to compound Baloxavir To Be Published
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6R9H
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![BU of 6r9h by Molmil](/molmil-images/mine/6r9h) | |
6RLC
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![BU of 6rlc by Molmil](/molmil-images/mine/6rlc) | |
8PIE
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![BU of 8pie by Molmil](/molmil-images/mine/8pie) | Crystal structure of the human nucleoside diphosphate kinase B domain in complex with the product AT-8500 formed by catalysis of compound AT-9010 | 分子名称: | GLYCEROL, Nucleoside diphosphate kinase B, [(2~{R},3~{R},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-4-fluoranyl-4-methyl-3-oxidanyl-oxolan-2-yl]methyl phosphono hydrogen phosphate | 著者 | Feracci, M, Chazot, A, Ferron, F, Alvarez, K, Canard, B. | 登録日 | 2023-06-21 | 公開日 | 2024-07-31 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | The activation chain of the broad-spectrum antiviral bemnifosbuvir at atomic resolution Plos Biol., 2024
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5ELT
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![BU of 5elt by Molmil](/molmil-images/mine/5elt) | |
5EMO
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![BU of 5emo by Molmil](/molmil-images/mine/5emo) | |
5EL3
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![BU of 5el3 by Molmil](/molmil-images/mine/5el3) | Structure of the KH domain of T-STAR | 分子名称: | KH domain-containing, RNA-binding, signal transduction-associated protein 3, ... | 著者 | Dominguez, C, Feracci, M. | 登録日 | 2015-11-04 | 公開日 | 2016-01-13 | 最終更新日 | 2017-09-13 | 実験手法 | X-RAY DIFFRACTION (1.59 Å) | 主引用文献 | Structural basis of RNA recognition and dimerization by the STAR proteins T-STAR and Sam68. Nat Commun, 7, 2016
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5ELS
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5ELR
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8AAP
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![BU of 8aap by Molmil](/molmil-images/mine/8aap) | Crystal structure of the PDZ tandem of syntenin in complex with compound SYNTi | 分子名称: | (2S)-2-[[(2S)-2-(6-bromanyl-3-oxidanylidene-1H-isoindol-2-yl)-3-[4-(5-ethanoyl-2-fluoranyl-phenyl)phenyl]propanoyl]amino]propanoic acid, Syntenin-1 | 著者 | Feracci, M, Barral, K. | 登録日 | 2022-07-01 | 公開日 | 2023-04-26 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.174 Å) | 主引用文献 | Discovery of a PDZ Domain Inhibitor Targeting the Syndecan/Syntenin Protein-Protein Interaction: A Semi-Automated "Hit Identification-to-Optimization" Approach. J.Med.Chem., 66, 2023
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8AAO
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![BU of 8aao by Molmil](/molmil-images/mine/8aao) | Crystal structure of the PDZ tandem of syntenin in complex with compound 95 | 分子名称: | (2~{S})-2-[[(2~{S})-3-[4-(5-ethanoyl-2-fluoranyl-phenyl)phenyl]-2-(3-oxidanylidene-1~{H}-isoindol-2-yl)propanoyl]amino]propanoic acid, Syntenin-1 | 著者 | Feracci, M, Barral, K. | 登録日 | 2022-07-01 | 公開日 | 2023-04-26 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.469 Å) | 主引用文献 | Discovery of a PDZ Domain Inhibitor Targeting the Syndecan/Syntenin Protein-Protein Interaction: A Semi-Automated "Hit Identification-to-Optimization" Approach. J.Med.Chem., 66, 2023
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8AAI
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8AAK
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![BU of 8aak by Molmil](/molmil-images/mine/8aak) | Crystal structure of the PDZ tandem of syntenin in complex with compound 29 | 分子名称: | (2~{S})-2-[[(2~{S})-2-(3-oxidanylidene-1~{H}-isoindol-2-yl)-3-phenyl-propanoyl]amino]propanoic acid, GLYCEROL, Syntenin-1 | 著者 | Feracci, M, Barral, K. | 登録日 | 2022-07-01 | 公開日 | 2023-04-26 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.554 Å) | 主引用文献 | Discovery of a PDZ Domain Inhibitor Targeting the Syndecan/Syntenin Protein-Protein Interaction: A Semi-Automated "Hit Identification-to-Optimization" Approach. J.Med.Chem., 66, 2023
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8PYW
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![BU of 8pyw by Molmil](/molmil-images/mine/8pyw) | Crystal structure of the human Nucleoside-diphosphate kinase B domain bound to compound diphosphate form of AT-9052-Sp. | 分子名称: | GLYCEROL, Nucleoside diphosphate kinase B, [[(2R,3R,4R,5R)-5-(2-azanyl-6-oxidanylidene-1H-purin-9-yl)-4-fluoranyl-4-methyl-3-oxidanyl-oxolan-2-yl]methoxy-sulfanyl-phosphoryl] dihydrogen phosphate | 著者 | Feracci, M, Chazot, A. | 登録日 | 2023-07-26 | 公開日 | 2023-12-27 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.553 Å) | 主引用文献 | An exonuclease-resistant chain-terminating nucleotide analogue targeting the SARS-CoV-2 replicase complex. Nucleic Acids Res., 52, 2024
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2LKQ
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![BU of 2lkq by Molmil](/molmil-images/mine/2lkq) | NMR structure of the lambda 5 22-45 peptide | 分子名称: | Immunoglobulin lambda-like polypeptide 1 | 著者 | Elantak, L, Espeli, M, Boned, A, Bornet, O, Breton, C, Feracci, M, Roche, P, Guerlesquin, F, Schiff, C. | 登録日 | 2011-10-19 | 公開日 | 2012-10-24 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural Basis for Galectin-1-dependent Pre-B Cell Receptor (Pre-BCR) Activation. J.Biol.Chem., 287, 2012
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7ED5
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![BU of 7ed5 by Molmil](/molmil-images/mine/7ed5) | A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase | 分子名称: | MAGNESIUM ION, Non-structural protein 7, Non-structural protein 8, ... | 著者 | Shannon, A, Fattorini, V, Sama, B, Selisko, B, Feracci, M, Falcou, C, Gauffre, P, El Kazzi, P, Delpal, A, Decroly, E, Alvarez, K, Eydoux, C, Guillemot, J.-C, Moussa, A, Good, S, Colla, P, Lin, K, Sommadossi, J.-P, Zhu, Y.X, Yan, X.D, Shi, H, Ferron, F, Canard, B. | 登録日 | 2021-03-15 | 公開日 | 2022-02-16 | 最終更新日 | 2024-04-10 | 実験手法 | ELECTRON MICROSCOPY (2.98 Å) | 主引用文献 | A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase. Nat Commun, 13, 2022
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8BCR
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![BU of 8bcr by Molmil](/molmil-images/mine/8bcr) | DENV3 Methyltransferase in complexed with AT-9010 and SAH | 分子名称: | Genome polyprotein, PHOSPHATE ION, S-ADENOSYL-L-HOMOCYSTEINE, ... | 著者 | Gauffre, P, Fattorini, V, Canard, B, Ferron, F. | 登録日 | 2022-10-17 | 公開日 | 2023-03-22 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | AT-752 targets multiple sites and activities on the Dengue virus replication enzyme NS5. Antiviral Res., 212, 2023
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8PWK
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![BU of 8pwk by Molmil](/molmil-images/mine/8pwk) | human HINT1 in complex with compound AT8003 | 分子名称: | Histidine triad nucleotide-binding protein 1, SODIUM ION, [(2~{R},3~{R},4~{R},5~{R})-5-[2-azanyl-6-(methylamino)purin-9-yl]-4-fluoranyl-4-methyl-3-oxidanyl-oxolan-2-yl]methyl dihydrogen phosphate | 著者 | Zimberger, C, Canard, B, Ferron, F. | 登録日 | 2023-07-20 | 公開日 | 2024-07-31 | 実験手法 | X-RAY DIFFRACTION (2.095 Å) | 主引用文献 | The activation chain of the broad-spectrum antiviral bemnifosbuvir at atomic resolution Plos Biol., 2024
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8QCH
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8CB3
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![BU of 8cb3 by Molmil](/molmil-images/mine/8cb3) | SARS-CoV Macro domain complexed with 3-(N-morpholino)propanesulfonic acid | 分子名称: | 3[N-MORPHOLINO]PROPANE SULFONIC ACID, GLYCEROL, Papain-like protease nsp3 | 著者 | Morin, B, Ferron, F, Coutard, B, Canard, B, Marseilles Structural Genomics Program @ AFMB (MSGP) | 登録日 | 2023-01-25 | 公開日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.572 Å) | 主引用文献 | SARS-CoV Macro domain complexed with 3-(N-morpholino)propanesulfonic acid To Be Published
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8PTS
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![BU of 8pts by Molmil](/molmil-images/mine/8pts) | human GUK1 in complex with compound AT8001 | 分子名称: | GLYCEROL, Guanylate kinase, [(2~{R},3~{R},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-4-fluoranyl-4-methyl-3-oxidanyl-oxolan-2-yl]methyl dihydrogen phosphate | 著者 | Zimberger, C, Canard, B, Ferron, F. | 登録日 | 2023-07-14 | 公開日 | 2024-07-24 | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | 主引用文献 | Structural and functional basis for metabolic activation of the antiviral drug Bemnifosbuvir To Be Published
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