3T6P
 
 | | IAP antagonist-induced conformational change in cIAP1 promotes E3 ligase activation via dimerization | | 分子名称: | Baculoviral IAP repeat-containing protein 2, ZINC ION | | 著者 | Dueber, E.C, Schoeffler, A.J, Lingel, A, Elliott, M, Fedorova, A.V, Giannetti, A.M, Zobel, K, Maurer, B, Varfolomeev, E, Wu, P, Wallweber, H, Hymowitz, S, Deshayes, K, Vucic, D, Fairbrother, W.J. | | 登録日 | 2011-07-28 | | 公開日 | 2011-11-02 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.897 Å) | | 主引用文献 | Antagonists induce a conformational change in cIAP1 that promotes autoubiquitination.
Science, 334, 2011
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7UJD
 | | PSMD2 Structure bound to MC1 and Fab8/14 | | 分子名称: | 26S proteasome non-ATPase regulatory subunit 2, ACY-PHE-PRO-ASP-VAL-SAR-LEU-HIS-ARG-TYR-TRP-GLY-TRP-ASP-CYS-GLY-NH2, Fab 14 HC CDRs, ... | | 著者 | Johnson, M.C, Bashore, C, Ciferri, C, Dueber, E.C. | | 登録日 | 2022-03-30 | | 公開日 | 2023-01-11 | | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | | 主引用文献 | Targeted degradation via direct 26S proteasome recruitment.
Nat.Chem.Biol., 19, 2023
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7UIH
 | | PSMD2 Structure | | 分子名称: | 26S proteasome non-ATPase regulatory subunit 2, Fab 14 HC CDRs, Fab 14 LC CDRs, ... | | 著者 | Johnson, M.C, Bashore, C, Ciferri, C, Dueber, E.C. | | 登録日 | 2022-03-29 | | 公開日 | 2023-01-11 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Targeted degradation via direct 26S proteasome recruitment.
Nat.Chem.Biol., 19, 2023
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6N2M
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6N2P
 | | Helical assembly of the CARD9 CARD | | 分子名称: | Caspase recruitment domain-containing protein 9 | | 著者 | Holliday, M.J, Rohou, A, Arthur, C.P, Dueber, E.C, Fairbrother, W.J. | | 登録日 | 2018-11-13 | | 公開日 | 2019-07-03 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Structures of autoinhibited and polymerized forms of CARD9 reveal mechanisms of CARD9 and CARD11 activation.
Nat Commun, 10, 2019
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4EUU
 | | Structure of BX-795 Complexed with Human TBK1 Kinase Domain Phosphorylated on Ser172 | | 分子名称: | GLYCEROL, IODIDE ION, N-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide, ... | | 著者 | Ma, X, Helgason, E, Phung, Q.T, Quan, C.L, Iyer, R.S, Lee, M.W, Bowman, K.K, Starovasnik, M.A, Dueber, E.C. | | 登録日 | 2012-04-25 | | 公開日 | 2012-05-23 | | 最終更新日 | 2017-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Molecular basis of Tank-binding kinase 1 activation by transautophosphorylation.
Proc.Natl.Acad.Sci.USA, 109, 2012
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4EUT
 | | Structure of BX-795 Complexed with Unphosphorylated Human TBK1 Kinase-ULD Domain | | 分子名称: | IODIDE ION, N-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide, SULFATE ION, ... | | 著者 | Ma, X, Helgason, E, Phung, Q.T, Quan, C.L, Iyer, R.S, Lee, M.W, Bowman, K.K, Starovasnik, M.A, Dueber, E.C. | | 登録日 | 2012-04-25 | | 公開日 | 2012-05-23 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Molecular basis of Tank-binding kinase 1 activation by transautophosphorylation.
Proc.Natl.Acad.Sci.USA, 109, 2012
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6E26
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6E25
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7R9W
 | | LC3A in complex with Fragment 1-1 | | 分子名称: | 4-phenoxybenzoic acid, GLYCEROL, Microtubule-associated proteins 1A/1B light chain 3A | | 著者 | Rouge, L, Steffek, M, Helgason, E, Dueber, E, Mulvihill, M. | | 登録日 | 2021-06-29 | | 公開日 | 2022-01-12 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | A Multifaceted Hit-Finding Approach Reveals Novel LC3 Family Ligands.
Biochemistry, 62, 2023
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7R9Z
 | | LC3A in complex with Fragment 2-3 | | 分子名称: | (5-fluoro-1H-indol-3-yl)acetic acid, Microtubule-associated proteins 1A/1B light chain 3A | | 著者 | Rouge, L, Steffek, M, Helgason, E, Dueber, E, Mulvihill, M. | | 登録日 | 2021-06-29 | | 公開日 | 2022-01-12 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | | 主引用文献 | A Multifaceted Hit-Finding Approach Reveals Novel LC3 Family Ligands.
Biochemistry, 62, 2023
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7RA0
 | | LC3A in complex with Fragment 2-10 | | 分子名称: | (5-ethyl-2-methyl-1H-indol-3-yl)acetic acid, Microtubule-associated proteins 1A/1B light chain 3A | | 著者 | Rouge, L, Steffek, M, Helgason, E, Dueber, E, Mulvihill, M. | | 登録日 | 2021-06-29 | | 公開日 | 2022-01-12 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.36 Å) | | 主引用文献 | A Multifaceted Hit-Finding Approach Reveals Novel LC3 Family Ligands.
Biochemistry, 62, 2023
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6E27
 | | The CARD9 CARD domain-swapped dimer with a zinc ion bound to one of the two zinc binding sites | | 分子名称: | Caspase recruitment domain-containing protein 9, ZINC ION | | 著者 | Holliday, M.J, Ferrao, R, Boenig, G, Deuber, E.C, Fairbrother, W.J. | | 登録日 | 2018-07-10 | | 公開日 | 2018-09-26 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.811 Å) | | 主引用文献 | Picomolar zinc binding modulates formation of Bcl10-nucleating assemblies of the caspase recruitment domain (CARD) of CARD9.
J. Biol. Chem., 293, 2018
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6E28
 | | The CARD9 CARD domain-swapped dimer | | 分子名称: | Caspase recruitment domain-containing protein 9 | | 著者 | Holliday, M.J, Ferrao, R, Boenig, G, Deuber, E.C, Fairbrother, W.J. | | 登録日 | 2018-07-10 | | 公開日 | 2018-09-26 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.36 Å) | | 主引用文献 | Picomolar zinc binding modulates formation of Bcl10-nucleating assemblies of the caspase recruitment domain (CARD) of CARD9.
J. Biol. Chem., 293, 2018
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5CVM
 | | USP46~ubiquitin BEA covalent complex | | 分子名称: | Polyubiquitin-B, Ubiquitin carboxyl-terminal hydrolase 46, ZINC ION | | 著者 | Harris, S.F, Yin, J. | | 登録日 | 2015-07-27 | | 公開日 | 2015-10-07 | | 最終更新日 | 2015-11-11 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structural Insights into WD-Repeat 48 Activation of Ubiquitin-Specific Protease 46.
Structure, 23, 2015
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5CVL
 | | WDR48 (UAF-1), residues 2-580 | | 分子名称: | GOLD ION, PHOSPHATE ION, WD repeat-containing protein 48 | | 著者 | HARRIS, S.F, YIN, J. | | 登録日 | 2015-07-27 | | 公開日 | 2015-10-07 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structural Insights into WD-Repeat 48 Activation of Ubiquitin-Specific Protease 46.
Structure, 23, 2015
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5CVN
 | | WDR48 (2-580):USP46~ubiquitin ternary complex | | 分子名称: | Polyubiquitin-B, Ubiquitin carboxyl-terminal hydrolase 46, WD repeat-containing protein 48, ... | | 著者 | Harris, S.F, Yin, J. | | 登録日 | 2015-07-27 | | 公開日 | 2015-10-07 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (3.36 Å) | | 主引用文献 | Structural Insights into WD-Repeat 48 Activation of Ubiquitin-Specific Protease 46.
Structure, 23, 2015
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5CVO
 | | WDR48:USP46~ubiquitin ternary complex | | 分子名称: | Polyubiquitin-B, Ubiquitin carboxyl-terminal hydrolase 46, WD repeat-containing protein 48, ... | | 著者 | Harris, S.F, Yin, J. | | 登録日 | 2015-07-27 | | 公開日 | 2015-10-07 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (3.885 Å) | | 主引用文献 | Structural Insights into WD-Repeat 48 Activation of Ubiquitin-Specific Protease 46.
Structure, 23, 2015
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5KYC
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5KYF
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5KYB
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5KYE
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5KYD
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