4IBT
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![BU of 4ibt by Molmil](/molmil-images/mine/4ibt) | Human p53 core domain with hot spot mutation R273H and second-site suppressor mutation T284R | 分子名称: | Cellular tumor antigen p53, ZINC ION | 著者 | Diskin-Posner, Y, Eldar, A, Rozenberg, H, Shakked, Z. | 登録日 | 2012-12-09 | 公開日 | 2013-08-14 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structural studies of p53 inactivation by DNA-contact mutations and its rescue by suppressor mutations via alternative protein-DNA interactions. Nucleic Acids Res., 41, 2013
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5JVG
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![BU of 5jvg by Molmil](/molmil-images/mine/5jvg) | The large ribosomal subunit from Deinococcus radiodurans in complex with avilamycin | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 23S ribosomal RNA, 50S ribosomal protein L11, ... | 著者 | Krupkin, M, Wekselman, I, Matzov, D, Eyal, Z, Diskin Posner, Y, Rozenberg, H, Zimmerman, E, Bashan, A, Yonath, A. | 登録日 | 2016-05-11 | 公開日 | 2016-11-09 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (3.428 Å) | 主引用文献 | Avilamycin and evernimicin induce structural changes in rProteins uL16 and CTC that enhance the inhibition of A-site tRNA binding. Proc.Natl.Acad.Sci.USA, 113, 2016
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4IBV
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![BU of 4ibv by Molmil](/molmil-images/mine/4ibv) | Human p53 core domain with hot spot mutation R273C and second-site suppressor mutation S240R in sequence-specific complex with DNA | 分子名称: | 1,2-ETHANEDIOL, Cellular tumor antigen p53, DNA (5'-D(*CP*GP*GP*GP*CP*AP*TP*GP*CP*CP*CP*G)-3'), ... | 著者 | Eldar, A, Rozenberg, H, Diskin-Posner, Y, Shakked, Z. | 登録日 | 2012-12-09 | 公開日 | 2013-08-14 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural studies of p53 inactivation by DNA-contact mutations and its rescue by suppressor mutations via alternative protein-DNA interactions. Nucleic Acids Res., 41, 2013
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4IBY
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![BU of 4iby by Molmil](/molmil-images/mine/4iby) | Human p53 core domain with hot spot mutation R273H and second-site suppressor mutation S240R | 分子名称: | 1,2-ETHANEDIOL, Cellular tumor antigen p53, ZINC ION | 著者 | Eldar, A, Rozenberg, H, Diskin-Posner, Y, Shakked, Z. | 登録日 | 2012-12-09 | 公開日 | 2013-08-14 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Structural studies of p53 inactivation by DNA-contact mutations and its rescue by suppressor mutations via alternative protein-DNA interactions. Nucleic Acids Res., 41, 2013
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4IBQ
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![BU of 4ibq by Molmil](/molmil-images/mine/4ibq) | Human p53 core domain with hot spot mutation R273C | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, Cellular tumor antigen p53, ... | 著者 | Rozenberg, H, Eldar, A, Diskin-Posner, Y, Shakked, Z. | 登録日 | 2012-12-09 | 公開日 | 2013-08-14 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural studies of p53 inactivation by DNA-contact mutations and its rescue by suppressor mutations via alternative protein-DNA interactions. Nucleic Acids Res., 41, 2013
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4IBS
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![BU of 4ibs by Molmil](/molmil-images/mine/4ibs) | Human p53 core domain with hot spot mutation R273H (form I) | 分子名称: | 1,2-ETHANEDIOL, Cellular tumor antigen p53, ZINC ION | 著者 | Rozenberg, H, Eldar, A, Diskin-Posner, Y, Shakked, Z. | 登録日 | 2012-12-09 | 公開日 | 2013-08-14 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | 主引用文献 | Structural studies of p53 inactivation by DNA-contact mutations and its rescue by suppressor mutations via alternative protein-DNA interactions. Nucleic Acids Res., 41, 2013
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4IJT
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![BU of 4ijt by Molmil](/molmil-images/mine/4ijt) | Human p53 core domain with hot spot mutation R273H (form II) | 分子名称: | 1,2-ETHANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Cellular tumor antigen p53, ... | 著者 | Rozenberg, H, Eldar, A, Diskin-Posner, Y, Shakked, Z. | 登録日 | 2012-12-23 | 公開日 | 2013-08-14 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | 主引用文献 | Structural studies of p53 inactivation by DNA-contact mutations and its rescue by suppressor mutations via alternative protein-DNA interactions. Nucleic Acids Res., 41, 2013
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4IBZ
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![BU of 4ibz by Molmil](/molmil-images/mine/4ibz) | Human p53 core domain with hot spot mutation R273C and second-site suppressor mutation T284R | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, Cellular tumor antigen p53, ... | 著者 | Eldar, A, Rozenberg, H, Diskin-Posner, Y, Shakked, Z. | 登録日 | 2012-12-09 | 公開日 | 2013-08-14 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | 主引用文献 | Structural studies of p53 inactivation by DNA-contact mutations and its rescue by suppressor mutations via alternative protein-DNA interactions. Nucleic Acids Res., 41, 2013
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4IBU
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![BU of 4ibu by Molmil](/molmil-images/mine/4ibu) | Human p53 core domain with hot spot mutation R273C and second-site suppressor mutation T284R in sequence-specific complex with DNA | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, Cellular tumor antigen p53, ... | 著者 | Eldar, A, Rozenberg, H, Diskin-Posner, Y, Shakked, Z. | 登録日 | 2012-12-09 | 公開日 | 2013-08-14 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structural studies of p53 inactivation by DNA-contact mutations and its rescue by suppressor mutations via alternative protein-DNA interactions. Nucleic Acids Res., 41, 2013
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4IBW
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![BU of 4ibw by Molmil](/molmil-images/mine/4ibw) | Human p53 core domain with hot spot mutation R273H and second-site suppressor mutation T284R in sequence-specific complex with DNA | 分子名称: | 1,2-ETHANEDIOL, Cellular tumor antigen p53, DNA (5'-D(*CP*GP*GP*GP*CP*AP*TP*GP*CP*CP*CP*G)-3'), ... | 著者 | Eldar, A, Rozenberg, H, Diskin-Posner, Y, Shakked, Z. | 登録日 | 2012-12-09 | 公開日 | 2013-08-14 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.791 Å) | 主引用文献 | Structural studies of p53 inactivation by DNA-contact mutations and its rescue by suppressor mutations via alternative protein-DNA interactions. Nucleic Acids Res., 41, 2013
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6ZNC
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![BU of 6znc by Molmil](/molmil-images/mine/6znc) | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human wild-type p53DBD bound to DNA and MQ: wt-DNA-MQ (I) | 分子名称: | (2~{R})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, (2~{S})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, Cellular tumor antigen p53, ... | 著者 | Rozenberg, H, Degtjarik, O, Diskin-Posner, Y, Shakked, Z. | 登録日 | 2020-07-06 | 公開日 | 2021-12-08 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.64 Å) | 主引用文献 | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Nat Commun, 12, 2021
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7B4D
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![BU of 7b4d by Molmil](/molmil-images/mine/7b4d) | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R273C/S240R double mutant bound to DNA and MQ: R273C/S240R-DNA-MQ | 分子名称: | (2~{R})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, (2~{S})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, Cellular tumor antigen p53, ... | 著者 | Rozenberg, H, Diskin-Posner, Y, Degtjarik, O, Shakked, Z. | 登録日 | 2020-12-02 | 公開日 | 2021-12-08 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Nat Commun, 12, 2021
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7B4N
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![BU of 7b4n by Molmil](/molmil-images/mine/7b4n) | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human wild-type p53DBD bound to DNA and MQ: wt-DNA-MQ (II) | 分子名称: | (2~{R})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, (2~{S})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, Cellular tumor antigen p53, ... | 著者 | Rozenberg, H, Diskin-Posner, Y, Degtjarik, O, Shakked, Z. | 登録日 | 2020-12-02 | 公開日 | 2021-12-08 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.32 Å) | 主引用文献 | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Nat Commun, 12, 2021
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7B4H
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![BU of 7b4h by Molmil](/molmil-images/mine/7b4h) | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human wild-type p53DBD bound to DNA and MQ: wt-DNA-MQ (III) | 分子名称: | (2~{R})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, (2~{S})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, 1,2-ETHANEDIOL, ... | 著者 | Degtjarik, O, Rozenberg, H, Diskin-Posner, Y, Shakked, Z. | 登録日 | 2020-12-02 | 公開日 | 2021-12-08 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.39 Å) | 主引用文献 | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Nat Commun, 12, 2021
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3D05
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![BU of 3d05 by Molmil](/molmil-images/mine/3d05) | Human p53 core domain with hot spot mutation R249S (II) | 分子名称: | Cellular tumor antigen p53, ZINC ION | 著者 | Suad, O, Rozenberg, H, Shimon, L.J.W, Frolow, F, Shakked, Z. | 登録日 | 2008-05-01 | 公開日 | 2009-01-20 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structural basis of restoring sequence-specific DNA binding and transactivation to mutant p53 by suppressor mutations J.Mol.Biol., 385, 2009
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5MF7
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![BU of 5mf7 by Molmil](/molmil-images/mine/5mf7) | New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins (complex p53DBD-GADD45) | 分子名称: | Cellular tumor antigen p53, DI(HYDROXYETHYL)ETHER, DNA, ... | 著者 | Rozenberg, H, Diskin-Posner, Y, Golovenko, D, Shakked, Z. | 登録日 | 2016-11-17 | 公開日 | 2018-05-30 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.59 Å) | 主引用文献 | New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins. Structure, 26, 2018
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5JVH
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![BU of 5jvh by Molmil](/molmil-images/mine/5jvh) | |
3D08
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![BU of 3d08 by Molmil](/molmil-images/mine/3d08) | Human p53 core domain with hot spot mutation R249S and second-site suppressor mutation H168R | 分子名称: | Cellular tumor antigen p53, ZINC ION | 著者 | Suad, O, Rozenberg, H, Shimon, L.J.W, Frolow, F, Shakked, Z. | 登録日 | 2008-05-01 | 公開日 | 2009-01-20 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Structural basis of restoring sequence-specific DNA binding and transactivation to mutant p53 by suppressor mutations J.Mol.Biol., 385, 2009
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3D06
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![BU of 3d06 by Molmil](/molmil-images/mine/3d06) | Human p53 core domain with hot spot mutation R249S (I) | 分子名称: | Cellular tumor antigen p53, ZINC ION | 著者 | Rozenberg, H, Suad, O, Shimon, L.J.W, Frolow, F, Shakked, Z. | 登録日 | 2008-05-01 | 公開日 | 2009-01-20 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Structural basis of restoring sequence-specific DNA binding and transactivation to mutant p53 by suppressor mutations J.Mol.Biol., 385, 2009
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3D07
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![BU of 3d07 by Molmil](/molmil-images/mine/3d07) | |
3D09
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![BU of 3d09 by Molmil](/molmil-images/mine/3d09) | |
3D0A
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![BU of 3d0a by Molmil](/molmil-images/mine/3d0a) | |
7B49
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![BU of 7b49 by Molmil](/molmil-images/mine/7b49) | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R273H mutant bound to DNA and MQ: R273H-DNA-MQ | 分子名称: | (2~{R})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, (2~{S})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, 1,2-ETHANEDIOL, ... | 著者 | Rozenberg, H, Degtjarik, O, Shakked, Z. | 登録日 | 2020-12-02 | 公開日 | 2021-12-08 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.42 Å) | 主引用文献 | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Nat Commun, 12, 2021
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7B48
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![BU of 7b48 by Molmil](/molmil-images/mine/7b48) | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R273H mutant bound to MQ: R273H-MQ (II) | 分子名称: | (2~{S})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, 1,2-ETHANEDIOL, ACETATE ION, ... | 著者 | Degtjarik, O, Rozenberg, H, Shakked, Z. | 登録日 | 2020-12-02 | 公開日 | 2021-12-08 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Nat Commun, 12, 2021
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7B4B
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![BU of 7b4b by Molmil](/molmil-images/mine/7b4b) | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R273C mutant bound to MQ: R273C-MQ (I) | 分子名称: | (2~{R})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, (2~{S})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, 1,2-ETHANEDIOL, ... | 著者 | Degtjarik, O, Rozenberg, H, Shakked, Z. | 登録日 | 2020-12-02 | 公開日 | 2021-12-08 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | 主引用文献 | Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Nat Commun, 12, 2021
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