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6VBZ
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BU of 6vbz by Molmil
Crystal structure of the rat MLKL pseudokinase domain
分子名称: MANGANESE (II) ION, Mixed lineage kinase domain-like pseudokinase
著者Davies, K.A, Czabotar, P.E.
登録日2019-12-19
公開日2020-07-08
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.192 Å)
主引用文献Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologues.
Nat Commun, 11, 2020
6VC0
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BU of 6vc0 by Molmil
Crystal structure of the horse MLKL pseudokinase domain
分子名称: GLYCEROL, Mixed lineage kinase domain like pseudokinase
著者Davies, K.A, Czabotar, P.E.
登録日2019-12-19
公開日2020-07-08
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.746 Å)
主引用文献Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologues.
Nat Commun, 11, 2020
7MX3
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BU of 7mx3 by Molmil
Crystal structure of human RIPK3 complexed with GSK'843
分子名称: 1,2-ETHANEDIOL, 3-(1,3-benzothiazol-5-yl)-7-(1,3-dimethyl-1H-pyrazol-5-yl)thieno[3,2-c]pyridin-4-amine, Receptor-interacting serine/threonine-protein kinase 3
著者Davies, K.A, Czabotar, P.E.
登録日2021-05-18
公開日2021-11-24
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (3.23 Å)
主引用文献Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis.
Nat Commun, 12, 2021
8SLZ
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BU of 8slz by Molmil
Crystal structure of phosphorylated (T357/S358) human MLKL pseudokinase domain
分子名称: Mixed lineage kinase domain-like protein
著者Meng, Y, Davies, K.A, Czabotar, P.E, Murphy, J.M.
登録日2023-04-25
公開日2023-11-08
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Phosphorylation-dependent pseudokinase domain dimerization drives full-length MLKL oligomerization.
Nat Commun, 14, 2023
7MON
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BU of 7mon by Molmil
Structure of human RIPK3-MLKL complex
分子名称: Mixed lineage kinase domain-like protein, N-[4-({2-[(cyclopropanecarbonyl)amino]pyridin-4-yl}oxy)-3-fluorophenyl]-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide, Receptor-interacting serine/threonine-protein kinase 3
著者Meng, Y, Davies, K.A, Czabotar, P.E, Murphy, J.M.
登録日2021-05-03
公開日2021-11-17
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.23 Å)
主引用文献Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis.
Nat Commun, 12, 2021
8GET
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BU of 8get by Molmil
R. hominis 2 beta-glucuronidase bound to norquetiapine-glucuronide
分子名称: 11-(4-beta-D-glucopyranuronosylpiperazin-1-yl)dibenzo[b,f][1,4]thiazepine, FLAVIN MONONUCLEOTIDE, GLYCEROL, ...
著者Simpson, J.B, Redinbo, M.R.
登録日2023-03-07
公開日2024-03-20
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Gut microbial beta-glucuronidases influence endobiotic homeostasis and are modulated by diverse therapeutics.
Cell Host Microbe, 2024
8GEO
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BU of 8geo by Molmil
E. eligens beta-glucuronidase bound to 3-OH-desloratidine-glucuronide
分子名称: 8-chloro-11-(1-beta-D-glucopyranuronosylpiperidin-4-ylidene)-3-hydroxy-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine, Beta-glucuronidase, GLYCEROL
著者Simpson, J.B, Redinbo, M.R.
登録日2023-03-07
公開日2024-03-20
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (2.89 Å)
主引用文献Gut microbial beta-glucuronidases influence endobiotic homeostasis and are modulated by diverse therapeutics.
Cell Host Microbe, 2024
8GER
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BU of 8ger by Molmil
E. eligens beta-glucuronidase bound to norquetiapine-glucuronide
分子名称: 11-(4-beta-D-glucopyranuronosylpiperazin-1-yl)dibenzo[b,f][1,4]thiazepine, Beta-glucuronidase
著者Simpson, J.B, Lietzan, A.D, Redinbo, M.R.
登録日2023-03-07
公開日2024-03-20
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Gut microbial beta-glucuronidases influence endobiotic homeostasis and are modulated by diverse therapeutics.
Cell Host Microbe, 2024
6UX8
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BU of 6ux8 by Molmil
Structure of monobody 33 MLKL N-terminal domain complex
分子名称: Mixed lineage kinase domain-like protein, Monobody, ZINC ION
著者Birkinshaw, R.W, Petrie, E.J, Murphy, J.M.
登録日2019-11-07
公開日2020-04-01
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Identification of MLKL membrane translocation as a checkpoint in necroptotic cell death using Monobodies.
Proc.Natl.Acad.Sci.USA, 117, 2020

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件を2024-06-12に公開中

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