7MON

Structure of human RIPK3-MLKL complex

Summary for 7MON

• Entry DOI: 10.2210/pdb7mon/pdb
• Descriptor: Mixed lineage kinase domain-like protein, Receptor-interacting serine/threonine-protein kinase 3, N-[4-({2-[(cyclopropanecarbonyl)amino]pyridin-4-yl}oxy)-3-fluorophenyl]-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide, ... (4 entities in total)
• Functional Keywords: pseudokinase, kinase, complex, necroptosis, transferase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 68806.46

Authors

Meng, Y.,Davies, K.A.,Czabotar, P.E.,Murphy, J.M. (deposition date: 2021-05-03, release date: 2021-11-17, Last modification date: 2023-10-18)

• Primary citation: Meng, Y.,Davies, K.A.,Fitzgibbon, C.,Young, S.N.,Garnish, S.E.,Horne, C.R.,Luo, C.,Garnier, J.M.,Liang, L.Y.,Cowan, A.D.,Samson, A.L.,Lessene, G.,Sandow, J.J.,Czabotar, P.E.,Murphy, J.M.; Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis.; Nat Commun, 12:6783-6783, 2021; PubMed: 34811356; DOI: 10.1038/s41467-021-27032-x

Experimental method

X-RAY DIFFRACTION (2.23 Å)