7MON
Structure of human RIPK3-MLKL complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Mixed lineage kinase domain-like protein | polymer | 287 | 32736.8 | 1 | UniProt (Q8NB16) Pfam (PF07714) | Homo sapiens (Human) | hMLKL |
| 2 | B (B) | Receptor-interacting serine/threonine-protein kinase 3 | polymer | 316 | 35064.8 | 1 | UniProt (Q9Y572) Pfam (PF00069) | Homo sapiens (Human) | RIP-like protein kinase 3,Receptor-interacting protein 3,RIP-3 |
| 3 | C, D (A, B) | N-[4-({2-[(cyclopropanecarbonyl)amino]pyridin-4-yl}oxy)-3-fluorophenyl]-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide | non-polymer | 502.5 | 2 | Chemie (ZL1) | |||
| 4 | E, F (A, B) | water | water | 18.0 | 105 | Chemie (HOH) |
Sequence modifications
A: 190 - 471 (UniProt: Q8NB16)
B: 1 - 316 (UniProt: Q9Y572)
| PDB | External Database | Details |
|---|---|---|
| Gly 185 | - | expression tag |
| Ala 186 | - | expression tag |
| Met 187 | - | expression tag |
| Gly 188 | - | expression tag |
| Ser 189 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser 3 | Cys 3 | engineered mutation |
| Ala 110 | Cys 110 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 67801.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1004.9 | |
| All* | Total formula weight | 68806.5 |
