5DU8
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![BU of 5du8 by Molmil](/molmil-images/mine/5du8) | Crystal structure of M. tuberculosis EchA6 bound to GSK572A | 分子名称: | (5R,7S)-5-(4-ethylphenyl)-N-[(5-fluoropyridin-2-yl)methyl]-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide, Probable enoyl-CoA hydratase echA6 | 著者 | Cox, J.A.G, Besra, G.S, Futterer, K. | 登録日 | 2015-09-18 | 公開日 | 2016-01-20 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.23 Å) | 主引用文献 | THPP target assignment reveals EchA6 as an essential fatty acid shuttle in mycobacteria. Nat Microbiol, 1, 2016
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5DUC
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![BU of 5duc by Molmil](/molmil-images/mine/5duc) | Crystal structure of M. tuberculosis EchA6 bound to ligand GSK951A | 分子名称: | (5R,7S)-N-(1,3-benzodioxol-5-ylmethyl)-5-(4-ethylphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide, Probable enoyl-CoA hydratase echA6 | 著者 | Cox, J.A.G, Besra, G.S, Futterer, K. | 登録日 | 2015-09-18 | 公開日 | 2016-01-20 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.704 Å) | 主引用文献 | THPP target assignment reveals EchA6 as an essential fatty acid shuttle in mycobacteria. Nat Microbiol, 1, 2016
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5DUF
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![BU of 5duf by Molmil](/molmil-images/mine/5duf) | Crystal structure of M. tuberculosis EchA6 bound to ligand GSK729A | 分子名称: | (5R,7S)-5-(4-ethylphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxylic acid, Probable enoyl-CoA hydratase echA6 | 著者 | Cox, J.A.G, Besra, G.S, Futterer, K. | 登録日 | 2015-09-18 | 公開日 | 2016-01-20 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | THPP target assignment reveals EchA6 as an essential fatty acid shuttle in mycobacteria. Nat Microbiol, 1, 2016
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5DU6
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![BU of 5du6 by Molmil](/molmil-images/mine/5du6) | Crystal structure of M. tuberculosis EchA6 bound to ligand GSK059A. | 分子名称: | (5R,7R)-5-(4-ethylphenyl)-N-(4-fluorobenzyl)-7-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide, Probable enoyl-CoA hydratase echA6 | 著者 | Cox, J.A.G, Besra, G.S, Futterer, K. | 登録日 | 2015-09-18 | 公開日 | 2016-01-20 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.61 Å) | 主引用文献 | THPP target assignment reveals EchA6 as an essential fatty acid shuttle in mycobacteria. Nat Microbiol, 1, 2016
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5DTP
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5DU4
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![BU of 5du4 by Molmil](/molmil-images/mine/5du4) | Crystal structure of M. tuberculosis EchA6 bound to ligand GSK366A | 分子名称: | (5R,7S)-5-(4-ethylphenyl)-N-(4-methoxybenzyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide, Probable enoyl-CoA hydratase echA6 | 著者 | Cox, J.A.G, Besra, G.S, Futterer, K. | 登録日 | 2015-09-18 | 公開日 | 2016-01-20 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.702 Å) | 主引用文献 | THPP target assignment reveals EchA6 as an essential fatty acid shuttle in mycobacteria. Nat Microbiol, 1, 2016
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5DTW
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![BU of 5dtw by Molmil](/molmil-images/mine/5dtw) | |
6HRD
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![BU of 6hrd by Molmil](/molmil-images/mine/6hrd) | |
4RMF
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![BU of 4rmf by Molmil](/molmil-images/mine/4rmf) | Biochemical and structural characterization of mycobacterial aspartyl-tRNA synthetase AspS, a promising TB drug target | 分子名称: | 2,2-bis(hydroxymethyl)propane-1,3-diol, Aspartate--tRNA(Asp/Asn) ligase, FORMIC ACID | 著者 | Cox, J.A.G, Gurcha, S.S, Veeraraghavan, U, Besra, G.S, Futterer, K. | 登録日 | 2014-10-21 | 公開日 | 2014-11-19 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Biochemical and Structural Characterization of Mycobacterial Aspartyl-tRNA Synthetase AspS, a Promising TB Drug Target. Plos One, 9, 2014
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2SAS
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1M39
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![BU of 1m39 by Molmil](/molmil-images/mine/1m39) | Solution structure of the C-terminal fragment (F86-I165) of the human centrin 2 in calcium saturated form | 分子名称: | Caltractin, isoform 1 | 著者 | Matei, E, Miron, S, Blouquit, Y, Duchambon, P, Durussel, P, Cox, J.A, Craescu, C.T. | 登録日 | 2002-06-27 | 公開日 | 2003-03-25 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | C-terminal half of human centrin 2 behaves like a regulatory EF-hand domain Biochemistry, 42, 2003
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1Q80
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![BU of 1q80 by Molmil](/molmil-images/mine/1q80) | Solution structure and dynamics of Nereis sarcoplasmic calcium binding protein | 分子名称: | Sarcoplasmic calcium-binding protein | 著者 | Rabah, G, Popescu, R, Cox, J.A, Engelborghs, Y, Craescu, C.T. | 登録日 | 2003-08-20 | 公開日 | 2004-09-21 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure and internal dynamics of NSCP, a compact calcium-binding protein. Febs J., 272, 2005
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1C7W
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![BU of 1c7w by Molmil](/molmil-images/mine/1c7w) | NMR SOLUTION STRUCTURE OF THE CALCIUM-BOUND C-TERMINAL DOMAIN (W81-S161) OF CALCIUM VECTOR PROTEIN FROM AMPHIOXUS | 分子名称: | CALCIUM VECTOR PROTEIN | 著者 | Theret, I, Baladi, S, Cox, J.A, Sakamoto, H, Craescu, C.T. | 登録日 | 2000-03-27 | 公開日 | 2000-04-12 | 最終更新日 | 2023-12-27 | 実験手法 | SOLUTION NMR | 主引用文献 | Sequential calcium binding to the regulatory domain of calcium vector protein reveals functional asymmetry and a novel mode of structural rearrangement. Biochemistry, 39, 2000
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1C7V
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![BU of 1c7v by Molmil](/molmil-images/mine/1c7v) | NMR SOLUTION STRUCTURE OF THE CALCIUM-BOUND C-TERMINAL DOMAIN (W81-S161) OF CALCIUM VECTOR PROTEIN FROM AMPHIOXUS | 分子名称: | CALCIUM VECTOR PROTEIN | 著者 | Theret, I, Baladi, S, Cox, J.A, Sakamoto, H, Craescu, C.T. | 登録日 | 2000-03-27 | 公開日 | 2000-04-12 | 最終更新日 | 2023-12-27 | 実験手法 | SOLUTION NMR | 主引用文献 | Sequential calcium binding to the regulatory domain of calcium vector protein reveals functional asymmetry and a novel mode of structural rearrangement. Biochemistry, 39, 2000
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1J7R
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![BU of 1j7r by Molmil](/molmil-images/mine/1j7r) | Solution structure and backbone dynamics of the defunct EF-hand domain of Calcium Vector Protein | 分子名称: | Calcium Vector Protein | 著者 | Theret, I, Baladi, S, Cox, J.A, Gallay, J, Sakamoto, H, Craescu, C.T. | 登録日 | 2001-05-18 | 公開日 | 2001-06-06 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure and backbone dynamics of the defunct domain of calcium vector protein. Biochemistry, 40, 2001
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1J7Q
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![BU of 1j7q by Molmil](/molmil-images/mine/1j7q) | Solution structure and backbone dynamics of the defunct EF-hand domain of Calcium Vector Protein | 分子名称: | Calcium Vector Protein | 著者 | Theret, I, Baladi, S, Cox, J.A, Gallay, J, Sakamoto, H, Craescu, C.T. | 登録日 | 2001-05-18 | 公開日 | 2001-06-06 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure and backbone dynamics of the defunct domain of calcium vector protein. Biochemistry, 40, 2001
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4AKL
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![BU of 4akl by Molmil](/molmil-images/mine/4akl) | Structure of the Crimean-Congo Haemorrhagic Fever Virus Nucleocapsid Protein | 分子名称: | NUCLEOCAPSID, TRIETHYLENE GLYCOL | 著者 | Carter, S.D, Walter, C.T, Surtees, R, Bergeron, E, Ariza, A, Albarino, C.G, Nichol, S.T, Hiscox, J.A, Edwards, T.A, Barr, J.N. | 登録日 | 2012-02-24 | 公開日 | 2012-08-22 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structure, Function, and Evolution of the Crimean-Congo Hemorrhagic Fever Virus Nucleocapsid Protein. J.Virol., 86, 2012
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4C3D
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![BU of 4c3d by Molmil](/molmil-images/mine/4c3d) | HRSV M2-1, P422 crystal form | 分子名称: | CADMIUM ION, MATRIX M2-1 | 著者 | Tanner, S.J, Ariza, A, Richard, C.A, Wu, W, Trincao, J, Hiscox, J.A, Carroll, M.W, Silman, N.J, Eleouet, J.F, Edwards, T.A, Barr, J.N. | 登録日 | 2013-08-22 | 公開日 | 2014-01-22 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.52 Å) | 主引用文献 | Crystal Structure of the Essential Transcription Antiterminator M2-1 Protein of Human Respiratory Syncytial Virus and Implications of its Phosphorylation. Proc.Natl.Acad.Sci.USA, 111, 2014
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4C3B
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![BU of 4c3b by Molmil](/molmil-images/mine/4c3b) | HRSV M2-1, P21 crystal form | 分子名称: | MATRIX PROTEIN 2-1, ZINC ION | 著者 | Tanner, S.J, Ariza, A, Richard, C.A, Wu, W, Trincao, J, Hiscox, J.A, Carroll, M.W, Silman, N.J, Eleouet, J.F, Edwards, T.A, Barr, J.N. | 登録日 | 2013-08-22 | 公開日 | 2014-01-22 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | 主引用文献 | Crystal Structure of the Essential Transcription Antiterminator M2-1 Protein of Human Respiratory Syncytial Virus and Implications of its Phosphorylation. Proc.Natl.Acad.Sci.USA, 111, 2014
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4C3E
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![BU of 4c3e by Molmil](/molmil-images/mine/4c3e) | HRSV M2-1 mutant S58D S61D, P21 crystal | 分子名称: | MATRIX M2-1, ZINC ION | 著者 | Tanner, S.J, Ariza, A, Richard, C.A, Wu, W, Trincao, J, Hiscox, J.A, Carroll, M.W, Silman, N.J, Eleouet, J.F, Edwards, T.A, Barr, J.N. | 登録日 | 2013-08-22 | 公開日 | 2014-01-22 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal Structure of the Essential Transcription Antiterminator M2-1 Protein of Human Respiratory Syncytial Virus and Implications of its Phosphorylation. Proc.Natl.Acad.Sci.USA, 111, 2014
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3ZL9
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![BU of 3zl9 by Molmil](/molmil-images/mine/3zl9) | Crystal structure of the nucleocapsid protein from Schmallenberg virus | 分子名称: | NUCLEOCAPSID PROTEIN | 著者 | Ariza, A, Tanner, S.J, Walter, C.T, Dent, K.C, Shepherd, D.A, Wu, W, Matthews, S.V, Hiscox, J.A, Green, T.J, Luo, M, Elliot, R.M, Ashcroft, A.E, Stonehouse, N.J, Ranson, N.A, Barr, J.N, Edwards, T.A. | 登録日 | 2013-01-29 | 公開日 | 2013-05-01 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Nucleocapsid Protein Structures from Orthobunyaviruses Reveal Insight Into Ribonucleoprotein Architecture and RNA Polymerization. Nucleic Acids Res., 41, 2013
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3ZLA
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![BU of 3zla by Molmil](/molmil-images/mine/3zla) | Crystal structure of the nucleocapsid protein from Bunyamwera virus bound to RNA | 分子名称: | NUCLEOPROTEIN, RNA | 著者 | Ariza, A, Tanner, S.J, Walter, C.T, Dent, K.C, Shepherd, D.A, Wu, W, Matthews, S.V, Hiscox, J.A, Green, T.J, Luo, M, Elliot, R.M, Ashcroft, A.E, Stonehouse, N.J, Ranson, N.A, Barr, J.N, Edwards, T.A. | 登録日 | 2013-01-29 | 公開日 | 2013-05-01 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Nucleocapsid Protein Structures from Orthobunyaviruses Reveal Insight Into Ribonucleoprotein Architecture and RNA Polymerization. Nucleic Acids Res., 41, 2013
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4BP7
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![BU of 4bp7 by Molmil](/molmil-images/mine/4bp7) | Asymmetric structure of a virus-receptor complex | 分子名称: | COAT PROTEIN | 著者 | Dent, K.C, Thompson, R, Barker, A.M, Barr, J.N, Hiscox, J.A, Stockley, P.G, Ranson, N.A. | 登録日 | 2013-05-23 | 公開日 | 2013-07-17 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (39 Å) | 主引用文献 | The Asymmetric Structure of an Icosahedral Virus Bound its Receptor Suggests a Mechanism for Genome Release. Structure, 21, 2013
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5OCW
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![BU of 5ocw by Molmil](/molmil-images/mine/5ocw) | Structure of Mycobacterium tuberculosis tryptophan synthase in space group F222 | 分子名称: | 2-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]ACRYLIC ACID, Tryptophan synthase alpha chain, Tryptophan synthase beta chain | 著者 | Futterer, K, Abrahams, K, Cox, J.A.G, Besra, G.S. | 登録日 | 2017-07-03 | 公開日 | 2017-07-12 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (4 Å) | 主引用文献 | Inhibiting mycobacterial tryptophan synthase by targeting the inter-subunit interface. Sci Rep, 7, 2017
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5LD8
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![BU of 5ld8 by Molmil](/molmil-images/mine/5ld8) | |