5DTP

Crystal structure of M. tuberculosis EchA6 (apo, trigonal crystal form)

Summary for 5DTP

• Entry DOI: 10.2210/pdb5dtp/pdb
• Descriptor: Probable enoyl-CoA hydratase echA6 (2 entities in total)
• Functional Keywords: enoyl-coa hydratase-like, lyase, lipid binding protein
• Biological source: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
• Total number of polymer chains: 3
• Total formula weight: 84489.35

Authors

Cox, J.A.G.,Besra, G.S.,Futterer, K. (deposition date: 2015-09-18, release date: 2016-01-20, Last modification date: 2024-01-10)

• Primary citation: Cox, J.A.,Abrahams, K.A.,Alemparte, C.,Ghidelli-Disse, S.,Rullas, J.,Angulo-Barturen, I.,Singh, A.,Gurcha, S.S.,Nataraj, V.,Bethell, S.,Remuinan, M.J.,Encinas, L.,Jervis, P.J.,Cammack, N.C.,Bhatt, A.,Kruse, U.,Bantscheff, M.,Futterer, K.,Barros, D.,Ballell, L.,Drewes, G.,Besra, G.S.; THPP target assignment reveals EchA6 as an essential fatty acid shuttle in mycobacteria.; Nat Microbiol, 1:15006-15006, 2016; PubMed: 27571973; DOI: 10.1038/nmicrobiol.2015.6

Experimental method

X-RAY DIFFRACTION (1.91 Å)