6HAR
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![BU of 6har by Molmil](/molmil-images/mine/6har) | Crystal structure of Mesotrypsin in complex with APPI-M17C/I18F/F34C | 分子名称: | 1,2-ETHANEDIOL, Amyloid-beta A4 protein, CALCIUM ION, ... | 著者 | Shahar, A, Cohen, I, Radisky, E, Papo, N. | 登録日 | 2018-08-08 | 公開日 | 2019-02-06 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.497 Å) | 主引用文献 | Disulfide engineering of human Kunitz-type serine protease inhibitors enhances proteolytic stability and target affinity toward mesotrypsin. J.Biol.Chem., 294, 2019
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6BX8
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![BU of 6bx8 by Molmil](/molmil-images/mine/6bx8) | Human Mesotrypsin (PRSS3) Complexed with Tissue Factor Pathway Inhibitor Variant (TFPI1-KD1-K15R-I17C-I34C) | 分子名称: | SULFATE ION, Tissue factor pathway inhibitor, Trypsin-3 | 著者 | Coban, M, Sankaran, B, Cohen, I, Hockla, A, Papo, N, Radisky, E.S. | 登録日 | 2017-12-18 | 公開日 | 2019-02-06 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | Disulfide engineering of human Kunitz-type serine protease inhibitors enhances proteolytic stability and target affinity toward mesotrypsin. J. Biol. Chem., 294, 2019
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6GFI
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![BU of 6gfi by Molmil](/molmil-images/mine/6gfi) | Structure of Human Mesotrypsin in complex with APPI variant T11V/M17R/I18F/F34V | 分子名称: | 1,2-ETHANEDIOL, Amyloid-beta A4 protein, PRSS3 protein | 著者 | Shahar, A, Cohen, I, Radisky, E, Papo, N, Naftaly, S. | 登録日 | 2018-04-30 | 公開日 | 2018-09-12 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Mapping protein selectivity landscapes using multi-target selective screening and next-generation sequencing of combinatorial libraries. Nat Commun, 9, 2018
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5C67
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![BU of 5c67 by Molmil](/molmil-images/mine/5c67) | |
5NX1
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![BU of 5nx1 by Molmil](/molmil-images/mine/5nx1) | Combinatorial Engineering of Proteolytically Resistant APPI Variants that Selectively Inhibit Human Kallikrein 6 for Cancer Therapy | 分子名称: | Amyloid-beta A4 protein, Kallikrein-6 | 著者 | Shahar, A, Sananes, A, Radisky, E.S, Papo, N. | 登録日 | 2017-05-09 | 公開日 | 2018-05-30 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.853 Å) | 主引用文献 | A potent, proteolysis-resistant inhibitor of kallikrein-related peptidase 6 (KLK6) for cancer therapy, developed by combinatorial engineering. J.Biol.Chem., 293, 2018
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5JBT
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![BU of 5jbt by Molmil](/molmil-images/mine/5jbt) | Mesotrypsin in complex with cleaved amyloid precursor like protein 2 inhibitor (APLP2) | 分子名称: | Amyloid-like protein 2, CALCIUM ION, PRSS3 protein, ... | 著者 | Kayode, O, Wang, R, Pendlebury, D, Soares, A, Radisky, E.S. | 登録日 | 2016-04-13 | 公開日 | 2016-11-09 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | An Acrobatic Substrate Metamorphosis Reveals a Requirement for Substrate Conformational Dynamics in Trypsin Proteolysis. J. Biol. Chem., 291, 2016
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5NX3
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![BU of 5nx3 by Molmil](/molmil-images/mine/5nx3) | Combinatorial Engineering of Proteolytically Resistant APPI Variants that Selectively Inhibit Human Kallikrein 6 for Cancer Therapy | 分子名称: | Amyloid-beta A4 protein, Kallikrein-6 | 著者 | Shahar, A, Sananes, A, Radisky, E.S, Papo, N. | 登録日 | 2017-05-09 | 公開日 | 2018-05-30 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.296 Å) | 主引用文献 | A potent, proteolysis-resistant inhibitor of kallikrein-related peptidase 6 (KLK6) for cancer therapy, developed by combinatorial engineering. J.Biol.Chem., 293, 2018
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