1PU2
 
 | | Crystal Structure of the K246R Mutant of Aspartate Semialdehyde Dehydrogenase from Haemophilus influenzae | | 分子名称: | Aspartate-semialdehyde dehydrogenase | | 著者 | Blanco, J, Moore, R.A, Faehnle, C.R, Coe, D.M, Viola, R.E. | | 登録日 | 2003-06-23 | | 公開日 | 2004-07-27 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | | 主引用文献 | The role of substrate-binding groups in the mechanism of aspartate-beta-semialdehyde dehydrogenase.
Acta Crystallogr.,Sect.D, 60, 2004
|
|
1Q2X
 | | Crystal Structure of the E243D Mutant of Aspartate Semialdehyde Dehydrogenase from Haemophilus influenzae bound with substrate aspartate semialdehyde | | 分子名称: | Aspartate-semialdehyde dehydrogenase | | 著者 | Blanco, J, Moore, R.A, Faehnle, C.R, Coe, D.M, Viola, R.E. | | 登録日 | 2003-07-26 | | 公開日 | 2004-07-27 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | The role of substrate-binding groups in the mechanism of aspartate-beta-semialdehyde dehydrogenase.
Acta Crystallogr.,Sect.D, 60, 2004
|
|
1PS8
 | | Crystal Structure of the R270K Mutant of Aspartate Semialdehyde dehydrogenase from Haemophilus influenzae | | 分子名称: | Aspartate semialdehyde dehydrogenase | | 著者 | Blanco, J, Moore, R.A, Faehnle, C.R, Coe, D.M, Viola, R.E. | | 登録日 | 2003-06-20 | | 公開日 | 2004-07-27 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | The role of substrate-binding groups in the mechanism of aspartate-beta-semialdehyde dehydrogenase.
Acta Crystallogr.,Sect.D, 60, 2004
|
|
1PR3
 | | Crystal Structure of the R103K Mutant of Aspartate Semialdehyde dehydrogenase from Haemophilus influenzae | | 分子名称: | Aspartate semialdehyde dehydrogenase, PHOSPHATE ION | | 著者 | Blanco, J, Moore, R.A, Faehnle, C.R, Coe, D.M, Viola, R.E. | | 登録日 | 2003-06-19 | | 公開日 | 2004-07-27 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | The role of substrate-binding groups in the mechanism of aspartate-beta-semialdehyde dehydrogenase.
Acta Crystallogr.,Sect.D, 60, 2004
|
|
1T6L
 | | Crystal Structure of the Human Cytomegalovirus DNA Polymerase Subunit, UL44 | | 分子名称: | DNA polymerase processivity factor | | 著者 | Appleton, B.A, Loregian, A, Filman, D.J, Coen, D.M, Hogle, J.M. | | 登録日 | 2004-05-06 | | 公開日 | 2004-08-10 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | The Cytomegalovirus DNA Polymerase Subunit UL44 Forms a C Clamp-Shaped Dimer.
Mol.Cell, 15, 2004
|
|
5IWD
 | | HCMV DNA polymerase subunit UL44 complex with a small molecule | | 分子名称: | 5-methylidene-3-(methylsulfanyl)-2-benzothiophen-4(5H)-one, DNA polymerase processivity factor | | 著者 | Chen, H, Coen, D.M, Hogle, J.M, Filman, D.J. | | 登録日 | 2016-03-22 | | 公開日 | 2016-11-30 | | 最終更新日 | 2019-12-11 | | 実験手法 | X-RAY DIFFRACTION (2.56 Å) | | 主引用文献 | A Small Covalent Allosteric Inhibitor of Human Cytomegalovirus DNA Polymerase Subunit Interactions.
ACS Infect Dis, 3, 2017
|
|
5IXA
 | |
5A3G
 | | Structure of herpesvirus nuclear egress complex subunit M50 | | 分子名称: | M50 | | 著者 | Leigh, K.E, Boeszoermenyi, A, Mansueto, M.S, Sharma, M, Filman, D.J, Coen, D.M, Wagner, G, Hogle, J.M, Arthanari, H. | | 登録日 | 2015-06-01 | | 公開日 | 2015-07-15 | | 最終更新日 | 2024-06-19 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure of a Herpesvirus Nuclear Egress Complex Subunit Reveals an Interaction Groove that is Essential for Viral Replication
Proc.Natl.Acad.Sci.USA, 112, 2015
|
|
3I2M
 | | The Crystal Structure of PF-8, the DNA Polymerase Accessory Subunit from Kaposi s Sarcoma-Associated Herpesvirus | | 分子名称: | ORF59 | | 著者 | Baltz, J.L, Filman, D.J, Ciustea, M, Silverman, J.E.Y, Lautenschlager, C.L, Coen, D.M, Ricciardi, R.P, Hogle, J.M. | | 登録日 | 2009-06-29 | | 公開日 | 2010-05-12 | | 最終更新日 | 2021-10-13 | | 実験手法 | X-RAY DIFFRACTION (2.81 Å) | | 主引用文献 | The crystal structure of PF-8, the DNA polymerase accessory subunit from Kaposi's sarcoma-associated herpesvirus.
J.Virol., 83, 2009
|
|
3HSL
 | | The Crystal Structure of PF-8, the DNA Polymerase Accessory Subunit from Kaposi's Sarcoma-Associated Herpesvirus | | 分子名称: | ORF59 | | 著者 | Baltz, J.L, Filman, D.J, Ciustea, M, Silverman, J.E.Y, Lautenschlager, C.L, Coen, D.M, Ricciardi, R.P, Hogle, J.M. | | 登録日 | 2009-06-10 | | 公開日 | 2009-11-24 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | The crystal structure of PF-8, the DNA polymerase accessory subunit from Kaposi's sarcoma-associated herpesvirus.
J.Virol., 83, 2009
|
|
1DML
 | | CRYSTAL STRUCTURE OF HERPES SIMPLEX UL42 BOUND TO THE C-TERMINUS OF HSV POL | | 分子名称: | DNA POLYMERASE, DNA POLYMERASE PROCESSIVITY FACTOR | | 著者 | Zuccola, H.J, Filman, D.J, Coen, D.M, Hogle, J.M. | | 登録日 | 1999-12-14 | | 公開日 | 2000-03-15 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | The crystal structure of an unusual processivity factor, herpes simplex virus UL42, bound to the C terminus of its cognate polymerase.
Mol.Cell, 5, 2000
|
|
1YYP
 | | Crystal structure of cytomegalovirus UL44 bound to C-terminal peptide from CMV UL54 | | 分子名称: | 1,2-ETHANEDIOL, DNA polymerase, DNA polymerase processivity factor, ... | | 著者 | Appleton, B.A, Brooks, J, Loregian, A, Filman, D.J, Coen, D.M, Hogle, J.M. | | 登録日 | 2005-02-25 | | 公開日 | 2005-12-27 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Crystal structure of the cytomegalovirus DNA polymerase subunit UL44 in complex with the C terminus from the catalytic subunit. Differences in structure and function relative to unliganded UL44.
J.Biol.Chem., 281, 2006
|
|
7Q6H
 | |
7Q7K
 | |
7Q7L
 | |
7Q7I
 | |
7Q7W
 | |
3K22
 | | Glucocorticoid Receptor with Bound alaninamide 10 with TIF2 peptide | | 分子名称: | Glucocorticoid receptor, N-[(1R)-2-amino-1-methyl-2-oxoethyl]-3-(6-methyl-4-{[3,3,3-trifluoro-2-hydroxy-2-(trifluoromethyl)propyl]amino}-1H-indazol-1-yl)benzamide, Transcriptional Intermediary Factor 2, ... | | 著者 | Biggadike, K.B, McLay, I.M, Madauss, K.P, Williams, S.P, Bledsoe, R.K. | | 登録日 | 2009-09-29 | | 公開日 | 2010-08-11 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Design and x-ray crystal structures of high-potency nonsteroidal glucocorticoid agonists exploiting a novel binding site on the receptor.
Proc.Natl.Acad.Sci.USA, 106, 2009
|
|
3K23
 | | Glucocorticoid Receptor with Bound D-prolinamide 11 | | 分子名称: | 1-{[3-(4-{[(2R)-4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-(trifluoromethyl)pentyl]amino}-6-methyl-1H-indazol-1-yl)phenyl]carbonyl}-D-prolinamide, Glucocorticoid receptor, Nuclear receptor coactivator 2 | | 著者 | Biggadike, K.B, McLay, I.M, Madauss, K.P, Williams, S.P, Bledsoe, R.K. | | 登録日 | 2009-09-29 | | 公開日 | 2009-10-27 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Design and x-ray crystal structures of high-potency nonsteroidal glucocorticoid agonists exploiting a novel binding site on the receptor.
Proc.Natl.Acad.Sci.USA, 106, 2009
|
|
3O56
 | | Catalytic domain of human phosphodiesterase 4b2b in complex with a 5-heterocycle pyrazolopyridine inhibitor | | 分子名称: | 1-ethyl-5-[3-(2-oxo-2-pyrrolidin-1-ylethyl)-1,2,4-oxadiazol-5-yl]-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine, ARSENIC, GLYCEROL, ... | | 著者 | Somers, D.O, Neu, M. | | 登録日 | 2010-07-28 | | 公開日 | 2011-08-03 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.42 Å) | | 主引用文献 | Pyrazolopyridines as potent PDE4B inhibitors: 5-heterocycle SAR.
Bioorg.Med.Chem.Lett., 20, 2010
|
|
3O57
 | | Catalytic domain of human phosphodiesterase 4b2b in complex with a 5-heterocycle pyrazolopyridine inhibitor | | 分子名称: | 5-[5-benzyl-4-(2-oxo-2-pyrrolidin-1-ylethyl)-1,3-oxazol-2-yl]-1-ethyl-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine, ARSENIC, GLYCEROL, ... | | 著者 | Somers, D.O, Neu, M. | | 登録日 | 2010-07-28 | | 公開日 | 2011-08-03 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Pyrazolopyridines as potent PDE4B inhibitors: 5-heterocycle SAR.
Bioorg.Med.Chem.Lett., 20, 2010
|
|
1OZA
 | |
1PQP
 | | Crystal Structure of the C136S Mutant of Aspartate Semialdehyde Dehydrogenase from Haemophilus influenzae Bound with Aspartate Semialdehyde and Phosphate | | 分子名称: | Aspartate-semialdehyde dehydrogenase, L-HOMOSERINE, PHOSPHATE ION | | 著者 | Blanco, J, Moore, R.A, Faehnle, C.R, Viola, R.E. | | 登録日 | 2003-06-18 | | 公開日 | 2004-08-10 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | | 主引用文献 | The role of substrate-binding groups in the mechanism of aspartate-beta-semialdehyde dehydrogenase.
Acta Crystallogr.,Sect.D, 60, 2004
|
|
1PQU
 | | Crystal Structure of the H277N Mutant of Aspartate Semialdehyde Dehydrogenase from Haemophilus influenzae Bound with NADP, S-methyl cysteine sulfoxide and cacodylate | | 分子名称: | Aspartate-semialdehyde dehydrogenase, CACODYLATE ION, CYSTEINE, ... | | 著者 | Blanco, J, Moore, R.A, Viola, R.E. | | 登録日 | 2003-06-19 | | 公開日 | 2004-08-10 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | | 主引用文献 | The role of substrate-binding groups in the mechanism of aspartate-beta-semialdehyde dehydrogenase.
Acta Crystallogr.,Sect.D, 60, 2004
|
|
5DOE
 | | Crystal structure of the Human Cytomegalovirus UL53 (residues 72-292) | | 分子名称: | Virion egress protein UL31 homolog, ZINC ION | | 著者 | Lye, M.F, El Omari, K, Filman, D.J, Hogle, J.M. | | 登録日 | 2015-09-11 | | 公開日 | 2015-11-25 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Unexpected features and mechanism of heterodimer formation of a herpesvirus nuclear egress complex.
Embo J., 34, 2015
|
|
