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3O56

Catalytic domain of human phosphodiesterase 4b2b in complex with a 5-heterocycle pyrazolopyridine inhibitor

Summary for 3O56
Entry DOI10.2210/pdb3o56/pdb
Related3D3P 3O57
DescriptorcAMP-specific 3',5'-cyclic phosphodiesterase 4B, ZINC ION, MAGNESIUM ION, ... (7 entities in total)
Functional Keywordspde, hydrolase, phosphodiesterase, camp binding, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total formula weight41508.10
Authors
Somers, D.O.,Neu, M. (deposition date: 2010-07-28, release date: 2011-08-03, Last modification date: 2023-09-06)
Primary citationMitchell, C.J.,Ballantine, S.P.,Coe, D.M.,Cook, C.M.,Delves, C.J.,Dowle, M.D.,Edlin, C.D.,Hamblin, J.N.,Holman, S.,Johnson, M.R.,Jones, P.S.,Keeling, S.E.,Kranz, M.,Lindvall, M.,Lucas, F.S.,Neu, M.,Solanke, Y.E.,Somers, D.O.,Trivedi, N.A.,Wiseman, J.O.
Pyrazolopyridines as potent PDE4B inhibitors: 5-heterocycle SAR.
Bioorg.Med.Chem.Lett., 20:5803-5806, 2010
Cited by
PubMed: 20732811
DOI: 10.1016/j.bmcl.2010.07.136
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.42 Å)
Structure validation

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