3O57
Catalytic domain of human phosphodiesterase 4b2b in complex with a 5-heterocycle pyrazolopyridine inhibitor
Summary for 3O57
Entry DOI | 10.2210/pdb3o57/pdb |
Related | 3D3P 3O56 |
Descriptor | cAMP-specific 3',5'-cyclic phosphodiesterase 4B, ZINC ION, MAGNESIUM ION, ... (7 entities in total) |
Functional Keywords | pde, hydrolase, phosphodiesterase, camp binding, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 41505.14 |
Authors | Somers, D.O.,Neu, M. (deposition date: 2010-07-28, release date: 2011-08-03, Last modification date: 2023-09-06) |
Primary citation | Mitchell, C.J.,Ballantine, S.P.,Coe, D.M.,Cook, C.M.,Delves, C.J.,Dowle, M.D.,Edlin, C.D.,Hamblin, J.N.,Holman, S.,Johnson, M.R.,Jones, P.S.,Keeling, S.E.,Kranz, M.,Lindvall, M.,Lucas, F.S.,Neu, M.,Solanke, Y.E.,Somers, D.O.,Trivedi, N.A.,Wiseman, J.O. Pyrazolopyridines as potent PDE4B inhibitors: 5-heterocycle SAR. Bioorg.Med.Chem.Lett., 20:5803-5806, 2010 Cited by PubMed: 20732811DOI: 10.1016/j.bmcl.2010.07.136 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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