3O57
Catalytic domain of human phosphodiesterase 4b2b in complex with a 5-heterocycle pyrazolopyridine inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | polymer | 353 | 40583.9 | 1 | UniProt (Q07343) Pfam (PF00233) | Homo sapiens (human) | DPDE4, PDE32 |
| 2 | B (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 3 | C (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 4 | D, E, F (A) | ARSENIC | non-polymer | 74.9 | 3 | Chemie (ARS) | |||
| 5 | G (A) | 5-[5-benzyl-4-(2-oxo-2-pyrrolidin-1-ylethyl)-1,3-oxazol-2-yl]-1-ethyl-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine | non-polymer | 514.6 | 1 | Chemie (ZG2) | |||
| 6 | H (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 7 | I (A) | water | water | 18.0 | 297 | Chemie (HOH) |
Sequence modifications
A: 152 - 503 (UniProt: Q07343)
| PDB | External Database | Details |
|---|---|---|
| Met 151 | - | initiating methionine |
| Ala 482 | Ser 654 | engineered mutation |
| Ala 487 | Ser 659 | engineered mutation |
| Ala 489 | Ser 661 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 40583.9 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 921.2 | |
| All* | Total formula weight | 41505.1 |
