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Structural analysis of KSHV thymidylate synthase
分子名称:	2'-DEOXYURIDINE 5'-MONOPHOSPHATE, ORF70, TOMUDEX
著者	Choi, Y.M, Yeo, H.K, Park, Y.W, Lee, J.Y.
登録日	2016-10-21
公開日	2017-01-18
最終更新日	2023-11-08
実験手法	X-RAY DIFFRACTION (2.4 Å)
主引用文献	Structural Analysis of Thymidylate Synthase from Kaposi's Sarcoma-Associated Herpesvirus with the Anticancer Drug Raltitrexed. PLoS ONE, 11, 2016

5H39

Structural analysis of KSHV thymidylate synthase
分子名称:	2'-DEOXYURIDINE 5'-MONOPHOSPHATE, ORF70
著者	Choi, Y.M, Yeo, H.K, Park, Y.W, Lee, J.Y.
登録日	2016-10-21
公開日	2017-01-18
最終更新日	2023-11-08
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	Structural Analysis of Thymidylate Synthase from Kaposi's Sarcoma-Associated Herpesvirus with the Anticancer Drug Raltitrexed. PLoS ONE, 11, 2016

5H38

Structural analysis of KSHV thymidylate synthase
分子名称:	ORF70, PHOSPHATE ION
著者	Choi, Y.M, Yeo, H.K, Park, Y.W, Lee, J.Y.
登録日	2016-10-21
公開日	2017-01-18
最終更新日	2023-11-08
実験手法	X-RAY DIFFRACTION (1.7 Å)
主引用文献	Structural Analysis of Thymidylate Synthase from Kaposi's Sarcoma-Associated Herpesvirus with the Anticancer Drug Raltitrexed. PLoS ONE, 11, 2016

7KIL

Crystal structure of the mouse lipin-1 M-Lip domain with zinc
分子名称:	CHLORIDE ION, Isoform 2 of Phosphatidate phosphatase LPIN1, ZINC ION
著者	Gu, W, Airola, M.V.
登録日	2020-10-23
公開日	2021-07-07
最終更新日	2023-10-18
実験手法	X-RAY DIFFRACTION (1.898 Å)
主引用文献	The middle lipin domain adopts a membrane-binding dimeric protein fold. Nat Commun, 12, 2021

7KIH

Crystal structure of the mouse lipin-1 M-Lip domain
分子名称:	Isoform 2 of Phosphatidate phosphatase LPIN1
著者	Gu, W, Airola, M.V.
登録日	2020-10-23
公開日	2021-07-07
最終更新日	2024-05-22
実験手法	X-RAY DIFFRACTION (1.467 Å)
主引用文献	The middle lipin domain adopts a membrane-binding dimeric protein fold. Nat Commun, 12, 2021

7KIQ

Crystal structure of the mouse lipin-2 M-Lip domain
分子名称:	CALCIUM ION, Phosphatidate phosphatase LPIN2
著者	Yang, J.W, Gu, W, Airola, M.V.
登録日	2020-10-24
公開日	2021-07-07
最終更新日	2023-10-18
実験手法	X-RAY DIFFRACTION (2.523 Å)
主引用文献	The middle lipin domain adopts a membrane-binding dimeric protein fold. Nat Commun, 12, 2021

3L5T

Crystal structure of macrophage migration inhibitory factor (MIF) with thiophenepiperazinylquinolinone inhibitor at 1.86A resolution
分子名称:	1-methyl-2-oxo-4-[4-(thiophen-2-ylcarbonyl)piperazin-1-yl]-1,2-dihydroquinoline-3-carbonitrile, Macrophage migration inhibitory factor, SULFATE ION
著者	McLean, L, Zhang, Y.
登録日	2009-12-22
公開日	2010-03-09
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (1.86 Å)
主引用文献	Fragment screening of inhibitors for MIF tautomerase reveals a cryptic surface binding site. Bioorg.Med.Chem.Lett., 20, 2010

3L5R

Crystal structure of macrophage migration inhibitory factor (MIF) with phenylchromenone inhibitor at 1.94A resolution
分子名称:	3-(3,4-dihydroxyphenyl)-7-hydroxy-4H-chromen-4-one, GLYCEROL, Macrophage migration inhibitory factor, ...
著者	McLean, L, Zhang, Y.
登録日	2009-12-22
公開日	2010-03-09
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (1.94 Å)
主引用文献	Fragment screening of inhibitors for MIF tautomerase reveals a cryptic surface binding site. Bioorg.Med.Chem.Lett., 20, 2010

3L5U

Crystal structure of macrophage migration inhibitory factor (MIF) with benzothiazole inhibitor at 1.90A resolution
分子名称:	6-HYDROXY-1,3-BENZOTHIAZOLE-2-SULFONAMIDE, Macrophage migration inhibitory factor, SULFATE ION
著者	McLean, L, Zhang, Y.
登録日	2009-12-22
公開日	2010-03-09
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (1.9 Å)
主引用文献	Fragment screening of inhibitors for MIF tautomerase reveals a cryptic surface binding site. Bioorg.Med.Chem.Lett., 20, 2010

3L5S

Crystal structure of macrophage migration inhibitory factor (MIF) with imidazopyrimidinylphenyl inhibitor at 1.86A resolution
分子名称:	5-ethyl-2-(phenylcarbonyl)imidazo[1,2-a]pyrimidin-7(1H)-one, Macrophage migration inhibitory factor, SULFATE ION
著者	McLean, L, Zhang, Y.
登録日	2009-12-22
公開日	2010-03-09
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (1.86 Å)
主引用文献	Fragment screening of inhibitors for MIF tautomerase reveals a cryptic surface binding site. Bioorg.Med.Chem.Lett., 20, 2010

3L5V

Crystal structure of macrophage migration inhibitory factor (MIF) with glycerol at 1.70A resolution
分子名称:	GLYCEROL, Macrophage migration inhibitory factor, SULFATE ION
著者	McLean, L, Zhang, Y.
登録日	2009-12-22
公開日	2010-03-09
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (1.7 Å)
主引用文献	Fragment screening of inhibitors for MIF tautomerase reveals a cryptic surface binding site. Bioorg.Med.Chem.Lett., 20, 2010

3L5P

Crystal structure of macrophage migration inhibitory factor (MIF) with imidazopyridazinol inhibitor at 1.80A resolution
分子名称:	2-(1-methylethyl)imidazo[1,2-b]pyridazin-6-ol, GLYCEROL, Macrophage migration inhibitory factor, ...
著者	McLean, L, Zhang, Y.
登録日	2009-12-22
公開日	2010-03-09
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (1.8 Å)
主引用文献	Fragment screening of inhibitors for MIF tautomerase reveals a cryptic surface binding site. Bioorg.Med.Chem.Lett., 20, 2010

3JTU

Crystal structure of macrophage migration inhibitory factor (mif) with hydroxyquinoline inhibitor 708 at 1.86a resolution
分子名称:	7-(pyridin-2-ylmethyl)quinolin-8-ol, Macrophage migration inhibitory factor, SULFATE ION
著者	Mclean, L, Zhang, Y.
登録日	2009-09-14
公開日	2009-11-10
最終更新日	2024-10-09
実験手法	X-RAY DIFFRACTION (1.86 Å)
主引用文献	Discovery of covalent inhibitors for MIF tautomerase via cocrystal structures with phantom hits from virtual screening. Bioorg.Med.Chem.Lett., 19, 2009

3JSF

Crystal structure of macrophage migration inhibitory factor (mif) with hydroxyquinoline inhibitor 638 at 1.93a resolution
分子名称:	7-(2-fluorobenzyl)quinolin-8-ol, Macrophage migration inhibitory factor, SULFATE ION
著者	Mclean, L, Zhang, Y.
登録日	2009-09-10
公開日	2009-11-10
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (1.93 Å)
主引用文献	Discovery of covalent inhibitors for MIF tautomerase via cocrystal structures with phantom hits from virtual screening. Bioorg.Med.Chem.Lett., 19, 2009

3JSG

Crystal structure of macrophage migration inhibitory factor (mif) with hydroxyquinoline inhibitor 707 at 1.58a resolution
分子名称:	7-(pyridin-3-ylmethyl)quinolin-8-ol, Macrophage migration inhibitory factor, SULFATE ION
著者	Mclean, L, Zhang, Y.
登録日	2009-09-10
公開日	2009-11-10
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (1.58 Å)
主引用文献	Discovery of covalent inhibitors for MIF tautomerase via cocrystal structures with phantom hits from virtual screening. Bioorg.Med.Chem.Lett., 19, 2009

3V5L

Crystal Structure of Interleukin-2 Inducible T-cell Kinase Itk Catalytic Domain with Thienopyrazolylindole Inhibitor 542
分子名称:	3-[3-(4-methoxyphenyl)-2-(1H-thieno[3,2-c]pyrazol-3-yl)-1H-indol-6-yl]pentan-3-ol, SULFATE ION, Tyrosine-protein kinase ITK/TSK
著者	McLean, L.R, Zhang, Y.
登録日	2011-12-16
公開日	2012-05-02
最終更新日	2023-09-13
実験手法	X-RAY DIFFRACTION (1.86 Å)
主引用文献	X-ray crystallographic structure-based design of selective thienopyrazole inhibitors for interleukin-2-inducible tyrosine kinase. Bioorg.Med.Chem.Lett., 22, 2012

3VF8

Crystal Structure of Spleen Tyrosine Kinase Syk Catalytic Domain with Pyrazolylbenzimidazole Inhibitor 416
分子名称:	3-[5-(5-ethoxy-6-fluoro-1H-benzimidazol-2-yl)-1H-pyrazol-4-yl]-1,1-diethylurea, Tyrosine-protein kinase SYK
著者	McLean, L.R, Zhang, Y.
登録日	2012-01-09
公開日	2012-05-02
最終更新日	2024-02-28
実験手法	X-RAY DIFFRACTION (2.08 Å)
主引用文献	X-ray crystallographic structure-based design of selective thienopyrazole inhibitors for interleukin-2-inducible tyrosine kinase. Bioorg.Med.Chem.Lett., 22, 2012

3V8W

Crystal Structure of Interleukin-2 Inducible T-cell Kinase Itk Catalytic Domain with Thienopyrazolylindole Inhibitor 469
分子名称:	3-[2-(5-phenyl-2H-thieno[3,2-c]pyrazol-3-yl)-1H-indol-6-yl]pentan-3-ol, SULFATE ION, Tyrosine-protein kinase ITK/TSK
著者	McLean, L.R, Zhang, Y.
登録日	2011-12-23
公開日	2012-05-02
最終更新日	2023-09-13
実験手法	X-RAY DIFFRACTION (2.27 Å)
主引用文献	X-ray crystallographic structure-based design of selective thienopyrazole inhibitors for interleukin-2-inducible tyrosine kinase. Bioorg.Med.Chem.Lett., 22, 2012

3V8T

Crystal Structure of Interleukin-2 Inducible T-cell Kinase Itk Catalytic Domain with Thienopyrazolylindole Inhibitor 477
分子名称:	3-{2-[5-(difluoromethyl)-2H-thieno[3,2-c]pyrazol-3-yl]-1H-indol-6-yl}pentan-3-ol, SULFATE ION, Tyrosine-protein kinase ITK/TSK
著者	McLean, L.R, Zhang, Y.
登録日	2011-12-23
公開日	2012-05-02
最終更新日	2023-09-13
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	X-ray crystallographic structure-based design of selective thienopyrazole inhibitors for interleukin-2-inducible tyrosine kinase. Bioorg.Med.Chem.Lett., 22, 2012

3V5J

Crystal Structure of Interleukin-2 Inducible T-cell Kinase Itk Catalytic Domain with Thienopyrazolylindole Inhibitor 090
分子名称:	3-[4-(2-morpholin-4-ylethoxy)-2-(1~{H}-thieno[3,2-c]pyrazol-3-yl)-1~{H}-indol-6-yl]pentan-3-ol, SULFATE ION, Tyrosine-protein kinase ITK/TSK
著者	McLean, L.R, Zhang, Y.
登録日	2011-12-16
公開日	2012-05-02
最終更新日	2023-09-13
実験手法	X-RAY DIFFRACTION (2.59 Å)
主引用文献	X-ray crystallographic structure-based design of selective thienopyrazole inhibitors for interleukin-2-inducible tyrosine kinase. Bioorg.Med.Chem.Lett., 22, 2012

3VF9

Crystal Structure of Spleen Tyrosine Kinase Syk Catalytic Domain with Thienopyrazolylindole Inhibitor 027
分子名称:	3-{2-[5-(difluoromethyl)-2H-thieno[3,2-c]pyrazol-3-yl]-1H-indol-6-yl}pentan-3-ol, Tyrosine-protein kinase SYK
著者	McLean, L.R, Zhang, Y.
登録日	2012-01-09
公開日	2012-05-02
最終更新日	2024-02-28
実験手法	X-RAY DIFFRACTION (2.3 Å)
主引用文献	X-ray crystallographic structure-based design of selective thienopyrazole inhibitors for interleukin-2-inducible tyrosine kinase. Bioorg.Med.Chem.Lett., 22, 2012

全ヒット件数:	21
表示件数:	21
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