3VF8

Crystal Structure of Spleen Tyrosine Kinase Syk Catalytic Domain with Pyrazolylbenzimidazole Inhibitor 416

Summary for 3VF8

Entry DOI	10.2210/pdb3vf8/pdb
Related	3V5J 3V5L 3V8W 3VF9
Descriptor	Tyrosine-protein kinase SYK, 3-[5-(5-ethoxy-6-fluoro-1H-benzimidazol-2-yl)-1H-pyrazol-4-yl]-1,1-diethylurea (3 entities in total)
Functional Keywords	kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cell membrane : P43405
Total number of polymer chains	1
Total formula weight	35241.35
Authors	McLean, L.R.,Zhang, Y. (deposition date: 2012-01-09, release date: 2012-05-02, Last modification date: 2024-02-28)
Primary citation	McLean, L.R.,Zhang, Y.,Zaidi, N.,Bi, X.,Wang, R.,Dharanipragada, R.,Jurcak, J.G.,Gillespy, T.A.,Zhao, Z.,Musick, K.Y.,Choi, Y.M.,Barrague, M.,Peppard, J.,Smicker, M.,Duguid, M.,Parkar, A.,Fordham, J.,Kominos, D. X-ray crystallographic structure-based design of selective thienopyrazole inhibitors for interleukin-2-inducible tyrosine kinase. Bioorg.Med.Chem.Lett., 22:3296-3300, 2012 Cited by PubMed: 22464456 DOI: 10.1016/j.bmcl.2012.03.016 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.08 Å)

Structure validation