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5W2J
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BU of 5w2j by Molmil
Crystal structure of dimeric form of mouse Glutaminase C
分子名称: CHLORIDE ION, Glutaminase kidney isoform, mitochondrial, ...
著者Cerione, R.A, Li, Y.
登録日2017-06-06
公開日2018-10-17
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Mechanistic Basis of Glutaminase Activation: A KEY ENZYME THAT PROMOTES GLUTAMINE METABOLISM IN CANCER CELLS.
J. Biol. Chem., 291, 2016
1KV3
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BU of 1kv3 by Molmil
HUMAN TISSUE TRANSGLUTAMINASE IN GDP BOUND FORM
分子名称: GUANOSINE-5'-DIPHOSPHATE, Protein-glutamine gamma-glutamyltransferase
著者Liu, S, Cerione, R.A, Clardy, J.
登録日2002-01-24
公開日2002-03-13
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural basis for the guanine nucleotide-binding activity of tissue transglutaminase and its regulation of transamidation activity.
Proc.Natl.Acad.Sci.USA, 99, 2002
2QRZ
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BU of 2qrz by Molmil
Cdc42 bound to GMP-PCP: Induced Fit by Effector is Required
分子名称: Cell division control protein 42 homolog precursor, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, ...
著者Phillips, M.J, Calero, G, Chan, B, Cerione, R.A.
登録日2007-07-30
公開日2008-03-18
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Effector Proteins Exert an Important Influence on the Signaling-active State of the Small GTPase Cdc42.
J.Biol.Chem., 283, 2008
8ULG
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BU of 8ulg by Molmil
Cryo-EM structure of bovine phosphodiesterase 6 bound to IBMX
分子名称: 3-ISOBUTYL-1-METHYLXANTHINE, CYCLIC GUANOSINE MONOPHOSPHATE, MAGNESIUM ION, ...
著者Aplin, C, Cerione, R.A.
登録日2023-10-16
公開日2024-01-17
最終更新日2024-02-07
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Probing the mechanism by which the retinal G protein transducin activates its biological effector PDE6.
J.Biol.Chem., 300, 2023
8UGB
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BU of 8ugb by Molmil
Cryo-EM structure of bovine phosphodiesterase 6 bound to udenafil
分子名称: CYCLIC GUANOSINE MONOPHOSPHATE, MAGNESIUM ION, Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma, ...
著者Aplin, C, Cerione, R.A.
登録日2023-10-05
公開日2024-01-17
最終更新日2024-02-07
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Probing the mechanism by which the retinal G protein transducin activates its biological effector PDE6.
J.Biol.Chem., 300, 2023
8UFI
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BU of 8ufi by Molmil
Cryo-EM structure of bovine phosphodiesterase 6
分子名称: CYCLIC GUANOSINE MONOPHOSPHATE, MAGNESIUM ION, Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma, ...
著者Aplin, C, Cerione, R.A.
登録日2023-10-04
公開日2024-01-17
最終更新日2024-02-07
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Probing the mechanism by which the retinal G protein transducin activates its biological effector PDE6.
J.Biol.Chem., 300, 2023
8UGS
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BU of 8ugs by Molmil
Cryo-EM structure of bovine phosphodiesterase 6 bound to cGMP
分子名称: CYCLIC GUANOSINE MONOPHOSPHATE, MAGNESIUM ION, Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma, ...
著者Aplin, C, Cerione, R.A.
登録日2023-10-06
公開日2024-01-17
最終更新日2024-02-07
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Probing the mechanism by which the retinal G protein transducin activates its biological effector PDE6.
J.Biol.Chem., 300, 2023
7JSN
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BU of 7jsn by Molmil
Structure of the Visual Signaling Complex between Transducin and Phosphodiesterase 6
分子名称: 2-{2-ETHOXY-5-[(4-ETHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-5-METHYL-7-PROPYLIMIDAZO[5,1-F][1,2,4]TRIAZIN-4(1H)-ONE, GUANOSINE-3',5'-MONOPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ...
著者Gao, Y, Eskici, G, Ramachandran, S, Skiniotis, G, Cerione, R.A.
登録日2020-08-15
公開日2020-10-21
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Structure of the Visual Signaling Complex between Transducin and Phosphodiesterase 6.
Mol.Cell, 80, 2020
6UJG
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BU of 6ujg by Molmil
Crystal structure of human GAC in complex with inhibitor UPGL00012
分子名称: Glutaminase kidney isoform, mitochondrial, N-{5-[(3S)-3-{[5-(acetylamino)-1,3,4-thiadiazol-2-yl]amino}pyrrolidin-1-yl]-1,3,4-thiadiazol-2-yl}acetamide
著者Huang, Q, Cerione, R.A.
登録日2019-10-03
公開日2020-10-07
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Crystal structure of human GAC in complex with inhibitor UPGL00012
To Be Published
6UMD
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BU of 6umd by Molmil
Crystal structure of human GAC in complex with inhibitor UPGL00012
分子名称: 2-(pyridin-3-yl)-N-(5-{4-[(5-{[(pyridin-3-yl)acetyl]amino}-1,3,4-thiadiazol-2-yl)amino]piperidin-1-yl}-1,3,4-thiadiazol-2-yl)acetamide, Glutaminase kidney isoform, mitochondrial
著者Huang, Q, Cerione, R.A.
登録日2019-10-09
公開日2020-10-14
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Crystal structure of human GAC in complex with inhibitor UPGL00012
To Be Published
6UME
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BU of 6ume by Molmil
Crystal structure of human GAC in complex with inhibitor UPGL00012
分子名称: 2-(pyridin-3-yl)-N-(5-{4-[(5-{[(pyridin-3-yl)acetyl]amino}-1,3,4-thiadiazol-2-yl)amino]piperidin-1-yl}-1,3,4-thiadiazol-2-yl)acetamide, Glutaminase kidney isoform, mitochondrial
著者Huang, Q, Cerione, R.A.
登録日2019-10-09
公開日2020-10-14
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Crystal structure of human GAC in complex with inhibitor UPGL00012
To Be Published
6UMC
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BU of 6umc by Molmil
Crystal structure of human GAC in complex with inhibitor UPGL00012
分子名称: 2-phenyl-N-{5-[(3R)-3-({5-[(phenylacetyl)amino]-1,3,4-thiadiazol-2-yl}oxy)pyrrolidin-1-yl]-1,3,4-thiadiazol-2-yl}acetamide, Glutaminase kidney isoform, mitochondrial
著者Huang, Q, Cerione, R.A.
登録日2019-10-09
公開日2020-10-14
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Crystal structure of human GAC in complex with inhibitor UPGL00012
To Be Published
6ULJ
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BU of 6ulj by Molmil
Crystal structure of human GAC in complex with inhibitor UPGL00012
分子名称: 2-phenyl-N-{6-[4-({6-[(phenylacetyl)amino]pyridazin-3-yl}oxy)piperidin-1-yl]pyridazin-3-yl}acetamide, Glutaminase kidney isoform, mitochondrial
著者Huang, Q, Cerione, R.A.
登録日2019-10-08
公開日2020-10-14
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.69 Å)
主引用文献Crystal structure of human GAC in complex with inhibitor UPGL00045
To Be Published
6UMF
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BU of 6umf by Molmil
Crystal structure of human GAC in complex with inhibitor UPGL00012
分子名称: Glutaminase kidney isoform, mitochondrial, N-(5-{[1-(5-amino-1,3,4-thiadiazol-2-yl)piperidin-4-yl]oxy}-1,3,4-thiadiazol-2-yl)-2-phenylacetamide
著者Huang, Q, Cerione, R.A.
登録日2019-10-09
公開日2020-10-14
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.68 Å)
主引用文献Crystal structure of human GAC in complex with inhibitor UPGL00012
To Be Published
6UK6
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BU of 6uk6 by Molmil
Crystal structure of human GAC in complex with inhibitor UPGL00018
分子名称: 5-{4-[(5-amino-1,3,4-thiadiazol-2-yl)oxy]piperidin-1-yl}-1,3,4-thiadiazol-2-amine, Glutaminase kidney isoform, mitochondrial
著者Huang, Q, Cerione, R.A.
登録日2019-10-04
公開日2020-10-07
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Crystal structure of human GAC in complex with inhibitor UPGL00018
To Be Published
6UKB
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BU of 6ukb by Molmil
Crystal structure of human GAC in complex with inhibitor UPGL00012
分子名称: Glutaminase kidney isoform, mitochondrial, N-[5-(4-{[5-(acetylamino)-1,3,4-thiadiazol-2-yl]oxy}piperidin-1-yl)-1,3,4-thiadiazol-2-yl]acetamide
著者Huang, Q, Cerione, R.A.
登録日2019-10-04
公開日2020-10-07
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Crystal structure of human GAC in complex with inhibitor UPGL00020
To Be Published
6UJM
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BU of 6ujm by Molmil
Crystal structure of human GAC in complex with inhibitor UPGL00013
分子名称: Glutaminase kidney isoform, mitochondrial, N-{5-[(3R)-3-{[5-(acetylamino)-1,3,4-thiadiazol-2-yl]amino}pyrrolidin-1-yl]-1,3,4-thiadiazol-2-yl}acetamide
著者Huang, Q, Cerione, R.A.
登録日2019-10-03
公開日2020-10-07
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structure of human GAC in complex with inhibitor UPGL00013
To Be Published
6ULA
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BU of 6ula by Molmil
Crystal structure of human GAC in complex with inhibitor UPGL00012
分子名称: 2-cyclopropyl-N-{5-[4-({5-[(cyclopropylacetyl)amino]-1,3,4-thiadiazol-2-yl}oxy)piperidin-1-yl]-1,3,4-thiadiazol-2-yl}acetamide, Glutaminase kidney isoform, mitochondrial
著者Huang, Q, Cerione, R.A.
登録日2019-10-07
公開日2020-10-14
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.95 Å)
主引用文献Crystal structure of human GAC in complex with inhibitor UPGL00030
To Be Published
6UL9
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BU of 6ul9 by Molmil
Crystal structure of human GAC in complex with inhibitor UPGL00023
分子名称: 2-phenyl-N-{5-[(1-{5-[(phenylacetyl)amino]-1,3,4-thiadiazol-2-yl}azetidin-3-yl)oxy]-1,3,4-thiadiazol-2-yl}acetamide, Glutaminase kidney isoform, mitochondrial
著者Huang, Q.Q, Cerione, R.A.
登録日2019-10-07
公開日2020-10-14
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structure of human GAC in complex with inhibitor UPGL00012
To Be Published
1PZD
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BU of 1pzd by Molmil
Structural Identification of a conserved appendage domain in the carboxyl-terminus of the COPI gamma-subunit.
分子名称: Coatomer gamma subunit, SULFATE ION
著者Hoffman, G.R, Rahl, P.B, Collins, R.N, Cerione, R.A.
登録日2003-07-10
公開日2003-10-14
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献Conserved Structural Motifs in Intracellular Trafficking Pathways. Structure of the gammaCOP Appendage Domain.
Mol.Cell, 12, 2003
6OYA
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BU of 6oya by Molmil
Structure of the Rhodopsin-Transducin-Nanobody Complex
分子名称: Camelid antibody VHH fragment, Gt-alpha/Gi1-alpha chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Gao, Y, Hu, H, Ramachandran, S, Erickson, J.W, Cerione, R.A, Skiniotis, G.
登録日2019-05-14
公開日2019-07-24
最終更新日2024-11-06
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Structures of the Rhodopsin-Transducin Complex: Insights into G-Protein Activation.
Mol.Cell, 75, 2019
6OY9
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BU of 6oy9 by Molmil
Structure of the Rhodopsin-Transducin Complex
分子名称: Gt-alpha/Gi1-alpha chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(T) subunit gamma-T1, ...
著者Gao, Y, Hu, H, Ramachandran, S, Erickson, J.W, Cerione, R.A, Skiniotis, G.
登録日2019-05-14
公開日2019-07-24
最終更新日2019-12-04
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Structures of the Rhodopsin-Transducin Complex: Insights into G-Protein Activation.
Mol.Cell, 75, 2019
3FEY
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BU of 3fey by Molmil
Crystal structure of the CBC-importin alpha complex.
分子名称: Importin subunit alpha-2, Nuclear cap-binding protein subunit 1, Nuclear cap-binding protein subunit 2
著者Dias, S.M.G, Ambrosio, A.L.B, Cerione, R.A.
登録日2008-12-01
公開日2009-08-11
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献The molecular basis for the regulation of the cap-binding complex by the importins.
Nat.Struct.Mol.Biol., 16, 2009
3FEX
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BU of 3fex by Molmil
Crystal structure of the CBC-importin alpha complex.
分子名称: Importin subunit alpha-2, Nuclear cap-binding protein subunit 1, Nuclear cap-binding protein subunit 2
著者Dias, S.M.G, Ambrosio, A.L.B, Cerione, R.A.
登録日2008-12-01
公開日2009-08-11
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (3.549 Å)
主引用文献The molecular basis for the regulation of the cap-binding complex by the importins.
Nat.Struct.Mol.Biol., 16, 2009
7SBM
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BU of 7sbm by Molmil
Human glutaminase C (Y466W) with L-Gln, open conformation
分子名称: GLUTAMINE, Isoform 3 of Glutaminase kidney isoform, mitochondrial
著者Nguyen, T.-T.T, Cerione, R.A.
登録日2021-09-25
公開日2022-02-02
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献High-resolution structures of mitochondrial glutaminase C tetramers indicate conformational changes upon phosphate binding.
J.Biol.Chem., 298, 2022

 

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