233D
 
 | | THE CRYSTAL STRUCTURE ANALYSIS OF D(CGCGAASSCGCG)2: A SYNTHETIC DNA DODECAMER DUPLEX CONTAINING FOUR 4'-THIO-2'-DEOXYTHYMIDINE NUCLEOTIDES | | 分子名称: | DNA (5'-D(*CP*GP*CP*GP*AP*AP*)-D(*(T49)P*(T49)P*)-D(*CP*GP*CP*G)-3') | | 著者 | Boggon, T.J, Hancox, E.L, McAuley-Hecht, K.E, Connolly, B.A, Hunter, W.N, Brown, T, Walker, R.T, Leonard, G.A. | | 登録日 | 1995-10-16 | | 公開日 | 1996-06-21 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | The crystal structure analysis of d(CGCGAASSCGCG)2, a synthetic DNA dodecamer duplex containing four 4'-thio-2'-deoxythymidine nucleotides.
Nucleic Acids Res., 24, 1996
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1L3W
 | | C-cadherin Ectodomain | | 分子名称: | 2-acetamido-2-deoxy-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | Boggon, T.J, Murray, J, Chappuis-Flament, S, Wong, E, Gumbiner, B.M, Shapiro, L. | | 登録日 | 2002-03-01 | | 公開日 | 2002-04-26 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (3.08 Å) | | 主引用文献 | C-cadherin ectodomain structure and implications for cell adhesion mechanisms
Science, 296, 2002
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1C8Z
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1YVJ
 | | Crystal structure of the Jak3 kinase domain in complex with a staurosporine analogue | | 分子名称: | (2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, 1,2,3,4-TETRAHYDROGEN-STAUROSPORINE, Tyrosine-protein kinase JAK3 | | 著者 | Boggon, T.J, Li, Y, Manley, P.W, Eck, M.J. | | 登録日 | 2005-02-15 | | 公開日 | 2005-05-24 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | Crystal structure of the Jak3 kinase domain in complex with a staurosporine analog
Blood, 106, 2005
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8GI4
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1I7E
 | | C-Terminal Domain Of Mouse Brain Tubby Protein bound to Phosphatidylinositol 4,5-bis-phosphate | | 分子名称: | L-ALPHA-GLYCEROPHOSPHO-D-MYO-INOSITOL-4,5-BIS-PHOSPHATE, TUBBY PROTEIN | | 著者 | Santagata, S, Boggon, T.J, Baird, C.L, Shan, W.S, Shapiro, L. | | 登録日 | 2001-03-08 | | 公開日 | 2001-06-27 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | G-protein signaling through tubby proteins.
Science, 292, 2001
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8DGQ
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7LNY
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7LO0
 | | Structure of human ASF1a in complex with a TLK2 peptide | | 分子名称: | Histone chaperone ASF1A, Serine/threonine-protein kinase tousled-like 2 | | 著者 | Simon, B, Calderwood, D, Turk, B.E, Boggon, T.J. | | 登録日 | 2021-02-08 | | 公開日 | 2022-02-16 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.71 Å) | | 主引用文献 | Tousled-like kinase 2 targets ASF1 histone chaperones through client mimicry.
Nat Commun, 13, 2022
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3IXE
 | | Structural basis of competition between PINCH1 and PINCH2 for binding to the ankyrin repeat domain of integrin-linked kinase | | 分子名称: | Integrin-linked protein kinase, LIM and senescent cell antigen-like-containing domain protein 2, ZINC ION | | 著者 | Chiswell, B.P, Stiegler, A.L, Boggon, T.J, Calderwood, D.A. | | 登録日 | 2009-09-03 | | 公開日 | 2009-12-15 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structural basis of competition between PINCH1 and PINCH2 for binding to the ankyrin repeat domain of integrin-linked kinase.
J.Struct.Biol., 170, 2010
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3F6Q
 | | Crystal structure of integrin-linked kinase ankyrin repeat domain in complex with PINCH1 LIM1 domain | | 分子名称: | IODIDE ION, Integrin-linked protein kinase, LIM and senescent cell antigen-like-containing domain protein 1, ... | | 著者 | Chiswell, B.P, Calderwood, D.A, Boggon, T.J. | | 登録日 | 2008-11-06 | | 公開日 | 2008-12-02 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | The structural basis of integrin-linked kinase-PINCH interactions.
Proc.Natl.Acad.Sci.USA, 105, 2008
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4DX9
 | | ICAP1 in complex with integrin beta 1 cytoplasmic tail | | 分子名称: | Integrin beta-1, Integrin beta-1-binding protein 1 | | 著者 | Liu, W, Draheim, K, Zhang, R, Calderwood, D.A, Boggon, T.J. | | 登録日 | 2012-02-27 | | 公開日 | 2013-01-09 | | 最終更新日 | 2020-09-02 | | 実験手法 | X-RAY DIFFRACTION (2.99 Å) | | 主引用文献 | Mechanism for KRIT1 Release of ICAP1-Mediated Suppression of Integrin Activation.
Mol.Cell, 49, 2013
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4PGZ
 | | Structural basis of KIT activation by oncogenic mutations in the extracellular region reveals a zipper-like mechanism for ligand-dependent or oncogenic receptor tyrosine kinase activation | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, COBALT (II) ION, Mast/stem cell growth factor receptor Kit | | 著者 | Reshetnyak, A.V, Boggon, T.J, Lax, I, Schlessinger, J. | | 登録日 | 2014-05-03 | | 公開日 | 2015-03-18 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | The strength and cooperativity of KIT ectodomain contacts determine normal ligand-dependent stimulation or oncogenic activation in cancer.
Mol.Cell, 57, 2015
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4Y5O
 | | CCM2 HHD in complex with MEKK3 NPB1 | | 分子名称: | Malcavernin, Mitogen-activated protein kinase kinase kinase 3 | | 著者 | Fisher, O.S, Boggon, T.J. | | 登録日 | 2015-02-11 | | 公開日 | 2015-07-01 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Structure and vascular function of MEKK3-cerebral cavernous malformations 2 complex.
Nat Commun, 6, 2015
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4TKN
 | | Structure of the SNX17 FERM domain bound to the second NPxF motif of KRIT1 | | 分子名称: | Krev interaction trapped protein 1, Sorting nexin-17 | | 著者 | Stiegler, A.L, Zhang, R, Liu, W, Boggon, T.J. | | 登録日 | 2014-05-27 | | 公開日 | 2014-07-30 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structural Determinants for Binding of Sorting Nexin 17 (SNX17) to the Cytoplasmic Adaptor Protein Krev Interaction Trapped 1 (KRIT1).
J.Biol.Chem., 289, 2014
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4TVQ
 | | CCM3 in complex with CCM2 LD-like motif | | 分子名称: | Cerebral cavernous malformations 2 protein, Cerebral cavernous malformations 3 protein | | 著者 | Li, X, Zhang, R, Fisher, O.S, Boggon, T.J. | | 登録日 | 2014-06-27 | | 公開日 | 2015-03-25 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | CCM2-CCM3 interaction stabilizes their protein expression and permits endothelial network formation.
J.Cell Biol., 208, 2015
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5D68
 | | Crystal structure of KRIT1 ARD-FERM | | 分子名称: | Krev interaction trapped protein 1 | | 著者 | Zhang, R, Li, X, Boggon, T.J. | | 登録日 | 2015-08-11 | | 公開日 | 2015-10-21 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.908 Å) | | 主引用文献 | Structural analysis of the KRIT1 ankyrin repeat and FERM domains reveals a conformationally stable ARD-FERM interface.
J.Struct.Biol., 192, 2015
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4WJ7
 | | CCM2 PTB domain in complex with KRIT1 NPxY/F3 | | 分子名称: | KRIT1 NPxY/F3, Malcavernin | | 著者 | Fisher, O.S, Liu, W, Zhang, R, Stiegler, A.L, Boggon, T.J. | | 登録日 | 2014-09-29 | | 公開日 | 2014-12-24 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.753 Å) | | 主引用文献 | Structural Basis for the Disruption of the Cerebral Cavernous Malformations 2 (CCM2) Interaction with Krev Interaction Trapped 1 (KRIT1) by Disease-associated Mutations.
J.Biol.Chem., 290, 2015
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4XLI
 | | Crystal structure of Abl2/Arg kinase in complex with dasatinib | | 分子名称: | N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE, Non-specific protein-tyrosine kinase, ZINC ION | | 著者 | Ha, B.H, Boggon, T.J. | | 登録日 | 2015-01-13 | | 公開日 | 2015-04-01 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structure of the ABL2/ARG kinase in complex with dasatinib.
Acta Crystallogr.,Sect.F, 71, 2015
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6PXC
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6PXB
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5HVJ
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5HVK
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3ULR
 | | Lysozyme contamination facilitates crystallization of a hetero-trimericCortactin:Arg:Lysozyme complex | | 分子名称: | Abelson tyrosine-protein kinase 2, Lysozyme C, Src substrate cortactin | | 著者 | Liu, W, MacGrath, S, Koleske, A.J, Boggon, T.J. | | 登録日 | 2011-11-11 | | 公開日 | 2012-01-11 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Lysozyme contamination facilitates crystallization of a heterotrimeric cortactin-Arg-lysozyme complex.
Acta Crystallogr.,Sect.F, 68, 2012
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3TH5
 | | Crystal structure of wild-type RAC1 | | 分子名称: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Ras-related C3 botulinum toxin substrate 1 | | 著者 | Ha, B.H, Boggon, T.J. | | 登録日 | 2011-08-18 | | 公開日 | 2012-07-18 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma.
Nat.Genet., 44, 2012
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