1MI7
 
 | | Crystal Structure of Domain Swapped trp Aporepressor in 30%(v/v) Isopropanol | | 分子名称: | ISOPROPYL ALCOHOL, Trp operon repressor | | 著者 | Lawson, C.L, Benoff, B, Berger, T, Berman, H.M, Carey, J. | | 登録日 | 2002-08-22 | | 公開日 | 2003-09-02 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | E. coli trp repressor forms a domain-swapped array in aqueous alcohol.
Structure, 12, 2004
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3UEK
 | | Crystal structure of the catalytic domain of rat poly (ADP-ribose) glycohydrolase | | 分子名称: | Poly(ADP-ribose) glycohydrolase | | 著者 | Kim, I.K, Kiefer, J.R, Stegemann, R.A, Classen, S, Tainer, J.A, Ellenberger, T. | | 登録日 | 2011-10-30 | | 公開日 | 2012-05-23 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Structure of mammalian poly(ADP-ribose) glycohydrolase reveals a flexible tyrosine clasp as a substrate-binding element.
Nat.Struct.Mol.Biol., 19, 2012
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3UEL
 | | Crystal structure of the catalytic domain of rat poly (ADP-ribose) glycohydrolase bound to ADP-HPD | | 分子名称: | 5'-O-[(S)-{[(S)-{[(2R,3R,4S)-3,4-DIHYDROXYPYRROLIDIN-2-YL]METHOXY}(HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]ADENOSINE, Poly(ADP-ribose) glycohydrolase | | 著者 | Kim, I.K, Kiefer, J.R, Stegemann, R.A, Classen, S, Tainer, J.A, Ellenberger, T. | | 登録日 | 2011-10-30 | | 公開日 | 2012-05-23 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structure of mammalian poly(ADP-ribose) glycohydrolase reveals a flexible tyrosine clasp as a substrate-binding element.
Nat.Struct.Mol.Biol., 19, 2012
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1NUI
 | | Crystal Structure of the primase fragment of Bacteriophage T7 primase-helicase protein | | 分子名称: | DNA primase/helicase, MAGNESIUM ION, ZINC ION | | 著者 | Kato, M, Ito, T, Wagner, G, Richardson, C.C, Ellenberger, T. | | 登録日 | 2003-01-31 | | 公開日 | 2003-05-27 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Modular Architecture of the Bacteriophage T7 Primase Couples RNA primer Synthesis to DNA Synthesis
Mol.Cell, 11, 2003
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6OA3
 | | Structure of human PARG complexed with JA2131 | | 分子名称: | (8S)-1,3-dimethyl-8-{[2-(morpholin-4-yl)ethyl]sulfanyl}-6-sulfanylidene-1,3,6,7,8,9-hexahydro-2H-purin-2-one, Poly(ADP-ribose) glycohydrolase | | 著者 | Stegeman, R.A, Jones, D.E, Ellenberger, T, Kim, I.K, Tainer, J.A. | | 登録日 | 2019-03-15 | | 公開日 | 2019-12-25 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death.
Nat Commun, 10, 2019
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6O9Y
 | | Structure of human PARG complexed with JA2-8 | | 分子名称: | 7-[(2S)-2-hydroxy-3-(morpholin-4-yl)propyl]-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione, Poly(ADP-ribose) glycohydrolase | | 著者 | Stegeman, R.A, Jones, D.E, Ellenberger, T, Kim, I.K, Tainer, J.A. | | 登録日 | 2019-03-15 | | 公開日 | 2019-12-25 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death.
Nat Commun, 10, 2019
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6OA0
 | | Structure of human PARG complexed with JA2-9 | | 分子名称: | 4-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)butanoic acid, Poly(ADP-ribose) glycohydrolase | | 著者 | Stegeman, R.A, Jones, D.E, Ellenberger, T, Kim, I.K, Tainer, J.A. | | 登録日 | 2019-03-15 | | 公開日 | 2019-12-25 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death.
Nat Commun, 10, 2019
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6O9X
 | | Structure of human PARG complexed with JA2-4 | | 分子名称: | 1,3-dimethyl-8-{[2-(pyrrolidin-1-yl)ethyl]sulfanyl}-6-sulfanylidene-1,3,6,9-tetrahydro-2H-purin-2-one, Poly(ADP-ribose) glycohydrolase | | 著者 | Stegeman, R.A, Jones, D.E, Ellenberger, T, Kim, I.K, Tainer, J.A. | | 登録日 | 2019-03-15 | | 公開日 | 2019-12-25 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death.
Nat Commun, 10, 2019
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6OA1
 | | Structure of human PARG complexed with JA2120 | | 分子名称: | 1,3-dimethyl-8-{[2-(morpholin-4-yl)ethyl]sulfanyl}-3,7-dihydro-1H-purine-2,6-dione, Poly(ADP-ribose) glycohydrolase | | 著者 | Stegeman, R.A, Jones, D.E, Ellenberger, T, Kim, I.K, Tainer, J.A. | | 登録日 | 2019-03-15 | | 公開日 | 2019-12-25 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death.
Nat Commun, 10, 2019
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6P7E
 | | Structure of T7 DNA Polymerase Bound to a Primer/Template DNA and a Peptide that Mimics the C-terminal Tail of the Primase-Helicase | | 分子名称: | ASP-THR-ASP-PHE peptide, DNA (25-MER), DNA (5'-D(P*GP*GP*CP*AP*GP*GP*TP*GP*GP*TP*CP*TP*TP*GP*CP*CP*GP*GP*TP*GP*A)-3'), ... | | 著者 | Foster, B.M, Rosenberg, D, Salvo, H, Stephens, K.L, Bintz, B.J, Hammel, M, Ellenberger, T, Gainey, M.D, Wallen, J.R. | | 登録日 | 2019-06-05 | | 公開日 | 2020-03-04 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (3.001 Å) | | 主引用文献 | Combined Solution and Crystal Methods Reveal the Electrostatic Tethers That Provide a Flexible Platform for Replication Activities in the Bacteriophage T7 Replisome.
Biochemistry, 58, 2019
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5KVH
 | | Crystal structure of human apoptosis-inducing factor with W196A mutation | | 分子名称: | Apoptosis-inducing factor 1, mitochondrial, FLAVIN-ADENINE DINUCLEOTIDE, ... | | 著者 | Brosey, C.A, Nix, J, Ellenberger, T, Tainer, J.A. | | 登録日 | 2016-07-14 | | 公開日 | 2016-11-16 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.273 Å) | | 主引用文献 | Defining NADH-Driven Allostery Regulating Apoptosis-Inducing Factor.
Structure, 24, 2016
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5KVI
 | | Crystal structure of monomeric human apoptosis-inducing factor with E413A/R422A/R430A mutations | | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Apoptosis-inducing factor 1, mitochondrial, ... | | 著者 | Brosey, C.A, Nix, J, Ellenberger, T, Tainer, J.A. | | 登録日 | 2016-07-14 | | 公開日 | 2016-11-16 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.995 Å) | | 主引用文献 | Defining NADH-Driven Allostery Regulating Apoptosis-Inducing Factor.
Structure, 24, 2016
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6WH1
 | | Structure of the complex of human DNA ligase III-alpha and XRCC1 BRCT domains | | 分子名称: | DNA ligase 3 alpha, X-ray repair cross complementing protein 1 variant | | 著者 | Pourfarjam, Y, Ellenberger, T, Tainer, J.A, Tomkinson, A.E, Kim, I.K. | | 登録日 | 2020-04-07 | | 公開日 | 2020-12-02 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | An atypical BRCT-BRCT interaction with the XRCC1 scaffold protein compacts human DNA Ligase III alpha within a flexible DNA repair complex.
Nucleic Acids Res., 49, 2021
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6WH2
 | | Structure of the C-terminal BRCT domain of human XRCC1 | | 分子名称: | X-ray repair cross complementing protein 1 variant | | 著者 | Pourfarjam, Y, Ellenberger, T, Tainer, J.A, Tomkinson, A.E, Kim, I.K. | | 登録日 | 2020-04-07 | | 公開日 | 2020-12-02 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.414 Å) | | 主引用文献 | An atypical BRCT-BRCT interaction with the XRCC1 scaffold protein compacts human DNA Ligase III alpha within a flexible DNA repair complex.
Nucleic Acids Res., 49, 2021
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1AE9
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1BNK
 | | HUMAN 3-METHYLADENINE DNA GLYCOSYLASE COMPLEXED TO DNA | | 分子名称: | DNA (5'-D(*GP*AP*CP*AP*TP*GP*YRRP*TP*TP*GP*CP*CP*T)-3'), DNA (5'-D(*GP*GP*CP*AP*AP*TP*CP*AP*TP*GP*TP*CP*A)-3'), PROTEIN (3-METHYLADENINE DNA GLYCOSYLASE) | | 著者 | Lau, A.Y, Schaerer, O.D, Samson, L, Verdine, G.L, Ellenberger, T. | | 登録日 | 1998-07-29 | | 公開日 | 1998-10-21 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Crystal structure of a human alkylbase-DNA repair enzyme complexed to DNA: mechanisms for nucleotide flipping and base excision.
Cell(Cambridge,Mass.), 95, 1998
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5IKN
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3L2P
 | | Human DNA Ligase III Recognizes DNA Ends by Dynamic Switching Between Two DNA Bound States | | 分子名称: | 5'-D(*GP*CP*CP*AP*GP*TP*CP*CP*GP*AP*CP*GP*AP*CP*GP*CP*AP*TP*CP*CP*CP*G)-3', 5'-D(*GP*TP*CP*GP*GP*AP*CP*TP*G)-3', 5'-D(P*CP*GP*GP*GP*AP*TP*GP*CP*GP*TP*C)-3', ... | | 著者 | Cotner-Gohara, E.A, Kim, I.K, Hammel, M, Tainer, J.A, Tomkinson, A, Ellenberger, T. | | 登録日 | 2009-12-15 | | 公開日 | 2010-07-14 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Human DNA Ligase III Recognizes DNA Ends by Dynamic Switching between Two DNA-Bound States.
Biochemistry, 49, 2010
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1CR1
 | | CRYSTAL STRUCTURE OF THE HELICASE DOMAIN OF THE GENE 4 PROTEIN OF BACTERIOPHAGE T7: COMPLEX WITH DTTP | | 分子名称: | DNA PRIMASE/HELICASE, SULFATE ION, THYMIDINE-5'-TRIPHOSPHATE | | 著者 | Sawaya, M.R, Guo, S, Tabor, S, Richardson, C.C, Ellenberger, T. | | 登録日 | 1999-08-12 | | 公開日 | 1999-11-10 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Crystal structure of the helicase domain from the replicative helicase-primase of bacteriophage T7.
Cell(Cambridge,Mass.), 99, 1999
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1CR4
 | | CRYSTAL STRUCTURE OF THE HELICASE DOMAIN OF THE GENE 4 PROTEIN OF BACTERIOPHAGE T7: COMPLEX WITH DTDP | | 分子名称: | DNA PRIMASE/HELICASE, SULFATE ION, THYMIDINE-5'-DIPHOSPHATE | | 著者 | Sawaya, M.R, Guo, S, Tabor, S, Richardson, C.C, Ellenberger, T. | | 登録日 | 1999-08-12 | | 公開日 | 1999-11-10 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Crystal structure of the helicase domain from the replicative helicase-primase of bacteriophage T7.
Cell(Cambridge,Mass.), 99, 1999
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1CR2
 | | CRYSTAL STRUCTURE OF THE HELICASE DOMAIN OF THE GENE 4 PROTEIN OF BACTERIOPHAGE T7: COMPLEX WITH DATP | | 分子名称: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA PRIMASE/HELICASE, SULFATE ION | | 著者 | Sawaya, M.R, Guo, S, Tabor, S, Richardson, C.C, Ellenberger, T. | | 登録日 | 1999-08-12 | | 公開日 | 1999-11-10 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Crystal structure of the helicase domain from the replicative helicase-primase of bacteriophage T7.
Cell(Cambridge,Mass.), 99, 1999
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1D5Y
 | | CRYSTAL STRUCTURE OF THE E. COLI ROB TRANSCRIPTION FACTOR IN COMPLEX WITH DNA | | 分子名称: | DNA (5'-D(*AP*CP*TP*TP*TP*GP*AP*CP*AP*TP*TP*CP*AP*GP*TP*GP*CP*TP*GP*TP*C)-3'), DNA (5'-D(*TP*GP*AP*CP*AP*GP*CP*AP*CP*TP*GP*AP*AP*TP*GP*TP*CP*AP*AP*AP*G)-3'), ROB TRANSCRIPTION FACTOR | | 著者 | Kwon, H.J, Bennik, M.H.J, Demple, B, Ellenberger, T. | | 登録日 | 1999-10-12 | | 公開日 | 2000-04-24 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Crystal structure of the Escherichia coli Rob transcription factor in complex with DNA.
Nat.Struct.Biol., 7, 2000
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2ONT
 | | A swapped dimer of the HIV-1 capsid C-terminal domain | | 分子名称: | Capsid protein p24 | | 著者 | Ivanov, D, Tsodikov, O.V, Kasanov, J, Ellenberger, T, Wagner, G, Collins, T. | | 登録日 | 2007-01-24 | | 公開日 | 2007-02-20 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Domain-swapped dimerization of the HIV-1 capsid C-terminal domain
Proc.Natl.Acad.Sci.Usa, 104, 2007
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5EWP
 | | ARO (armadillo repeats only protein) from Plasmodium falciparum | | 分子名称: | ARO (armadillo repeats only protein) | | 著者 | Brown, C, Zhang, K, Emery, J, Prusty, D, Wetzel, J, Heincke, D, Gilberger, T, Junop, M. | | 登録日 | 2015-11-20 | | 公開日 | 2016-01-27 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | ARO (armadillo repeats only protein) from Plasmodium falciparum
To Be Published
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1P7D
 | | Crystal structure of the Lambda Integrase (residues 75-356) bound to DNA | | 分子名称: | 26-MER, 5'-D(*CP*AP*AP*TP*GP*CP*CP*AP*AP*CP*TP*TP*T)-3', Integrase | | 著者 | Aihara, H, Kwon, H.J, Nunes-Duby, S.E, Landy, A, Ellenberger, T. | | 登録日 | 2003-05-01 | | 公開日 | 2003-08-12 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | | 主引用文献 | A Conformational Switch Controls the DNA Cleavage Activity of Lambda Integrase
Mol.Cell, 12, 2003
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