3UEL

Crystal structure of the catalytic domain of rat poly (ADP-ribose) glycohydrolase bound to ADP-HPD

Summary for 3UEL

Entry DOI	10.2210/pdb3uel/pdb
Related	3UEK
Descriptor	Poly(ADP-ribose) glycohydrolase, 5'-O-[(S)-{[(S)-{[(2R,3R,4S)-3,4-DIHYDROXYPYRROLIDIN-2-YL]METHOXY}(HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]ADENOSINE (2 entities in total)
Functional Keywords	mammalian parg, macrodomain, adp-hpd, hydrolase
Biological source	Rattus norvegicus (brown rat,rat,rats)
Cellular location	Nucleus (By similarity): Q9QYM2
Total number of polymer chains	3
Total formula weight	204967.46
Authors	Kim, I.K.,Kiefer, J.R.,Stegemann, R.A.,Classen, S.,Tainer, J.A.,Ellenberger, T. (deposition date: 2011-10-30, release date: 2012-05-23, Last modification date: 2024-02-28)
Primary citation	Kim, I.K.,Kiefer, J.R.,Ho, C.M.,Stegeman, R.A.,Classen, S.,Tainer, J.A.,Ellenberger, T. Structure of mammalian poly(ADP-ribose) glycohydrolase reveals a flexible tyrosine clasp as a substrate-binding element. Nat.Struct.Mol.Biol., 19:653-656, 2012 Cited by PubMed: 22609859 DOI: 10.1038/nsmb.2305 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation