6IAK
 
 | | The crystal structure of the chicken CREB3 bZIP | | 分子名称: | Uncharacterized protein | | 著者 | Sabaratnam, K, Renner, M. | | 登録日 | 2018-11-26 | | 公開日 | 2019-12-11 | | 最終更新日 | 2020-06-24 | | 実験手法 | X-RAY DIFFRACTION (3.95 Å) | | 主引用文献 | Insights from the crystal structure of the chicken CREB3 bZIP suggest that members of the CREB3 subfamily transcription factors may be activated in response to oxidative stress.
Protein Sci., 28, 2019
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4KYE
 | | Partial Structure of the C-terminal domain of the HPIV4B phosphoprotein, fused to MBP. | | 分子名称: | Maltose-binding periplasmic protein, Phosphoprotein, chimeric construct, ... | | 著者 | Yegambaram, K, Bulloch, E.M.M, Kingston, R.L. | | 登録日 | 2013-05-28 | | 公開日 | 2013-09-25 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Protein domain definition should allow for conditional disorder.
Protein Sci., 22, 2013
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4KYD
 | | Partial Structure of the C-terminal domain of the HPIV4B phosphoprotein, fused to MBP. | | 分子名称: | 3[N-MORPHOLINO]PROPANE SULFONIC ACID, Maltose-binding periplasmic protein, Phosphoprotein, ... | | 著者 | Yegambaram, K, Bulloch, E.M.M, Kingston, R.L. | | 登録日 | 2013-05-28 | | 公開日 | 2013-09-25 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | | 主引用文献 | Protein domain definition should allow for conditional disorder.
Protein Sci., 22, 2013
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4KYC
 | | Structure of the C-terminal domain of the Menangle virus phosphoprotein, fused to MBP. | | 分子名称: | 1,2-ETHANEDIOL, BORIC ACID, Maltose-binding periplasmic protein, ... | | 著者 | Yegambaram, K, Bulloch, E.M.M, Kingston, R.L. | | 登録日 | 2013-05-28 | | 公開日 | 2013-09-25 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Protein domain definition should allow for conditional disorder.
Protein Sci., 22, 2013
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3POK
 | | Interleukin-1-beta LBT L3 Mutant | | 分子名称: | Interleukin-1 beta | | 著者 | Barthelmes, K, Reynolds, A.M, Peisach, E, Jonker, H.R.A, DeNunzio, N.J, Allen, K.N, Imperiali, B, Schwalbe, H. | | 登録日 | 2010-11-22 | | 公開日 | 2011-01-19 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Engineering encodable lanthanide-binding tags into loop regions of proteins.
J.Am.Chem.Soc., 133, 2011
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1ZIT
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5M5B
 | | Crystal structure of Zika virus NS5 methyltransferase | | 分子名称: | CHLORIDE ION, GLYCEROL, NS5 methyltransferase, ... | | 著者 | Barral, K, Ortiz Lombardia, M, Coutard, B, Decroly, E, Lichiere, J. | | 登録日 | 2016-10-21 | | 公開日 | 2016-12-28 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | | 主引用文献 | Zika Virus Methyltransferase: Structure and Functions for Drug Design Perspectives.
J. Virol., 91, 2017
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5EC8
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5E9Q
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5EIF
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5EHG
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5EKX
 | | DENGUE 3 NS5 METHYLTRANSFERASE BOUND TO S-ADENOSYLMETHIONINE AND FRAGMENT NB2E11 | | 分子名称: | 4-chloro-5-methylbenzene-1,2-diamine, NS5 METHYLTRANSFERASE, S-ADENOSYLMETHIONINE | | 著者 | Barral, K, Bricogne, G, Sharff, A. | | 登録日 | 2015-11-04 | | 公開日 | 2016-10-26 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | | 主引用文献 | Discovery of novel dengue virus NS5 methyltransferase non-nucleoside inhibitors by fragment-based drug design.
Eur.J.Med.Chem., 125, 2016
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5EHI
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5EIW
 | | DENGUE 3 NS5 METHYLTRANSFERASE BOUND TO S-ADENOSYL METHIONINE AND FRAGMENT NB3C2 | | 分子名称: | 4-(TRIFLUOROMETHYL)BENZENE-1,2-DIAMINE, NS5 methyltransferase, S-ADENOSYLMETHIONINE | | 著者 | Barral, K, Bricogne, G, Sharff, A. | | 登録日 | 2015-10-30 | | 公開日 | 2016-10-26 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.611 Å) | | 主引用文献 | Discovery of novel dengue virus NS5 methyltransferase non-nucleoside inhibitors by fragment-based drug design.
Eur.J.Med.Chem., 125, 2016
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4CTK
 | | DENGUE 3 NS5 METHYLTRANSFERASE BOUND TO S-ADENOSYL METHIONINE AND FRAGMENT 2A4 | | 分子名称: | DIMETHYL SULFOXIDE, POLYPROTEIN, S-ADENOSYLMETHIONINE, ... | | 著者 | Barral, K, Bricogne, G, Sharff, A. | | 登録日 | 2014-03-14 | | 公開日 | 2014-04-16 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.53 Å) | | 主引用文献 | Assessment of Dengue Virus Helicase and Methyltransferase as Targets for Fragment-Based Drug Discovery.
Antiviral Res., 106, 2014
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4CTJ
 | | DENGUE 3 NS5 METHYLTRANSFERASE BOUND TO S-ADENOSYL METHIONINE AND FRAGMENT 3A9 | | 分子名称: | 2,3-dihydro-1-benzofuran-5-carboxylic acid, NON-STRUCTURAL PROTEIN 5, S-ADENOSYLMETHIONINE, ... | | 著者 | Barral, K, Bricogne, G, Sharff, A. | | 登録日 | 2014-03-14 | | 公開日 | 2014-04-16 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.47 Å) | | 主引用文献 | Assessment of Dengue Virus Helicase and Methyltransferase as Targets for Fragment-Based Drug Discovery.
Antiviral Res., 106, 2014
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2AGV
 | | Crystal structure of the SR CA2+-ATPASE with BHQ and TG | | 分子名称: | 2,5-DITERT-BUTYLBENZENE-1,4-DIOL, OCTANOIC ACID [3S-[3ALPHA, 3ABETA, ... | | 著者 | Toyoshima, C, Obara, K, Norimatsu, Y. | | 登録日 | 2005-07-27 | | 公開日 | 2005-10-25 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Inaugural Article: Structural role of countertransport revealed in Ca2+ pump crystal structure in the absence of Ca2+.
Proc.Natl.Acad.Sci.USA, 102, 2005
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1U3O
 | | Solution structure of rat Kalirin N-terminal SH3 domain | | 分子名称: | Huntingtin-associated protein-interacting protein | | 著者 | Schiller, M.R, Chakrabarti, K, King, G.F, Schiller, N.I, Eipper, B.A, Maciejewski, M.W. | | 登録日 | 2004-07-22 | | 公開日 | 2005-07-26 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Regulation of RhoGEF Activity by Intramolecular and Intermolecular SH3 Domain Interactions.
J.Biol.Chem., 281, 2006
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6VC1
 | | Octreotide oxalate | | 分子名称: | OXALATE ION, Octreotide | | 著者 | Spiliopoulou, M, Karavassili, F, Triandafillidis, D, Valmas, A, Kosinas, C, Fili, S, Barlos, K, Barlos, K.K, Morin, M, Reinle-Schmitt, M, Gozzo, F, Margiolaki, I. | | 登録日 | 2019-12-20 | | 公開日 | 2020-12-23 | | 最終更新日 | 2021-05-19 | | 実験手法 | POWDER DIFFRACTION | | 主引用文献 | New perspectives in macromolecular powder diffraction using single-photon-counting strip detectors: high-resolution structure of the pharmaceutical peptide octreotide.
Acta Crystallogr.,Sect.A, 77, 2021
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5JH7
 | | Tubulin-Eribulin complex | | 分子名称: | (1S,3S,6S,9S,12S,14R,16R,18S,20R,21R,22S,26R,29S,31R,32S,33R,35R,36S)-20-[(2S)-3-amino-2-hydroxypropyl]-21-methoxy-14-methyl-8,15-dimethylidene-2,19,30,34,37,39,40,41-octaoxanonacyclo[24.9.2.1~3,32~.1~3,33~.1~6,9~.1~12,16~.0~18,22~.0~29,36~.0~31,35~]hentetracontan-24-one (non-preferred name), 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | | 著者 | Doodhi, H, Prota, A.E, Rodriguez-Garcia, R, Xiao, H, Custar, D.W, Bargsten, K, Katrukha, E.A, Hilbert, M, Hua, S, Jiang, K, Grigoriev, I, Yang, C.-P.H, Cox, D, Band Horwitz, S, Kapitein, L.C, Akhmanova, A, Steinmetz, M.O. | | 登録日 | 2016-04-20 | | 公開日 | 2016-06-29 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Termination of Protofilament Elongation by Eribulin Induces Lattice Defects that Promote Microtubule Catastrophes.
Curr.Biol., 26, 2016
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5MF4
 | | Tubulin-Dictyostatin complex | | 分子名称: | (3~{Z},5~{E},7~{R},8~{S},10~{S},11~{Z},13~{S},14~{R},15~{S},17~{S},20~{R},21~{S},22~{S})-22-[(2~{S},3~{Z})-hexa-3,5-dien-2-yl]-7,13,15,17,21-pentamethyl-8,10,14,20-tetrakis(oxidanyl)-1-oxacyclodocosa-3,5,11-trien-2-one, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | | 著者 | Trigili, C, Barasoain, I, Sanchez-Murcia, P.A, Bargsten, K, Redondo-Horcajo, M, Nogales, A, Gardner, N.M, Meyer, A, Naylor, G.J, Gomez-Rubio, E, Gago, F, Steinmetz, M.O, Paterson, I, Prota, A.E, Diaz, J.F. | | 登録日 | 2016-11-17 | | 公開日 | 2017-09-20 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structural Determinants of the Dictyostatin Chemotype for Tubulin Binding Affinity and Antitumor Activity Against Taxane- and Epothilone-Resistant Cancer Cells.
ACS Omega, 1, 2016
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6BK0
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8AAK
 | | Crystal structure of the PDZ tandem of syntenin in complex with compound 29 | | 分子名称: | (2~{S})-2-[[(2~{S})-2-(3-oxidanylidene-1~{H}-isoindol-2-yl)-3-phenyl-propanoyl]amino]propanoic acid, GLYCEROL, Syntenin-1 | | 著者 | Feracci, M, Barral, K. | | 登録日 | 2022-07-01 | | 公開日 | 2023-04-26 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.554 Å) | | 主引用文献 | Discovery of a PDZ Domain Inhibitor Targeting the Syndecan/Syntenin Protein-Protein Interaction: A Semi-Automated "Hit Identification-to-Optimization" Approach.
J.Med.Chem., 66, 2023
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8AAP
 | | Crystal structure of the PDZ tandem of syntenin in complex with compound SYNTi | | 分子名称: | (2S)-2-[[(2S)-2-(6-bromanyl-3-oxidanylidene-1H-isoindol-2-yl)-3-[4-(5-ethanoyl-2-fluoranyl-phenyl)phenyl]propanoyl]amino]propanoic acid, Syntenin-1 | | 著者 | Feracci, M, Barral, K. | | 登録日 | 2022-07-01 | | 公開日 | 2023-04-26 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.174 Å) | | 主引用文献 | Discovery of a PDZ Domain Inhibitor Targeting the Syndecan/Syntenin Protein-Protein Interaction: A Semi-Automated "Hit Identification-to-Optimization" Approach.
J.Med.Chem., 66, 2023
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8AAO
 | | Crystal structure of the PDZ tandem of syntenin in complex with compound 95 | | 分子名称: | (2~{S})-2-[[(2~{S})-3-[4-(5-ethanoyl-2-fluoranyl-phenyl)phenyl]-2-(3-oxidanylidene-1~{H}-isoindol-2-yl)propanoyl]amino]propanoic acid, Syntenin-1 | | 著者 | Feracci, M, Barral, K. | | 登録日 | 2022-07-01 | | 公開日 | 2023-04-26 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.469 Å) | | 主引用文献 | Discovery of a PDZ Domain Inhibitor Targeting the Syndecan/Syntenin Protein-Protein Interaction: A Semi-Automated "Hit Identification-to-Optimization" Approach.
J.Med.Chem., 66, 2023
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