5MF4

Tubulin-Dictyostatin complex

Summary for 5MF4

Related5LXT 5LXS
DescriptorTubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ... (13 entities in total)
Functional Keywordscell cycle, tubulin fold, cytoskeleton, microtubule
Biological sourceRattus norvegicus (Norway Rat)
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Total number of polymer chains6
Total molecular weight265926.91
Authors
Primary citation
Trigili, C.,Barasoain, I.,Sanchez-Murcia, P.A.,Bargsten, K.,Redondo-Horcajo, M.,Nogales, A.,Gardner, N.M.,Meyer, A.,Naylor, G.J.,Gomez-Rubio, E.,Gago, F.,Steinmetz, M.O.,Paterson, I.,Prota, A.E.,Diaz, J.F.
Structural Determinants of the Dictyostatin Chemotype for Tubulin Binding Affinity and Antitumor Activity Against Taxane- and Epothilone-Resistant Cancer Cells.
ACS Omega, 1:1192-1204, 2016
PubMed: 30023505 (PDB entries with the same primary citation)
DOI: 10.1021/acsomega.6b00317
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.3 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.233110.0%1.6%7.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution