6RJP
 
 | | Bfl-1 in complex with alpha helical peptide | | 分子名称: | Bcl-2-like protein 11, Bcl-2-related protein A1 | | 著者 | Baggio, C, Gambini, L, Udompholkul, P, Salem, A.F, Hakansson, M, Jossart, J, Perry, J, Pellecchia, M. | | 登録日 | 2019-04-29 | | 公開日 | 2019-10-30 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.57 Å) | | 主引用文献 | N-locking stabilization of covalent helical peptides: Application to Bfl-1 antagonists.
Chem.Biol.Drug Des., 95, 2020
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7OFV
 | | NMR-guided design of potent and selective EphA4 agonistic ligands | | 分子名称: | ACETATE ION, EphA4 agonist ligand, Ephrin type-A receptor 4 | | 著者 | Ganichkin, O.M, Craig, T.K, Baggio, C, Pellecchia, M. | | 登録日 | 2021-05-05 | | 公開日 | 2021-08-11 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.43 Å) | | 主引用文献 | NMR-Guided Design of Potent and Selective EphA4 Agonistic Ligands.
J.Med.Chem., 64, 2021
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8GH7
 | | 142D6 bound to BIR3-XIAP | | 分子名称: | 2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL, BIR3 inhibitor MAA-CHG-PRO-ZHW, E3 ubiquitin-protein ligase XIAP, ... | | 著者 | Garza-Granados, A, McGuire, J, Baggio, C, Pellecchia, M, Pegan, S.D. | | 登録日 | 2023-03-09 | | 公開日 | 2023-07-05 | | 最終更新日 | 2023-07-12 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Characterization of a Potent and Orally Bioavailable Lys-Covalent Inhibitor of Apoptosis Protein (IAP) Antagonist.
J.Med.Chem., 66, 2023
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6B9L
 | | Crystal structure of EphA2 with peptide 135E2 | | 分子名称: | Ephrin type-A receptor 2, HIS TAG CLEAVED OFF, peptide 135E2, ... | | 著者 | Song, J, Tan, X. | | 登録日 | 2017-10-10 | | 公開日 | 2018-10-17 | | 最終更新日 | 2024-07-10 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Structure-Based Design of Novel EphA2 Agonistic Agents with Nanomolar Affinity in Vitro and in Cell.
ACS Chem. Biol., 13, 2018
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8VJP
 | | Histidine-covalent stapled alpha-helical peptide (155H1) targeting hMcl-1 | | 分子名称: | (4Z)-oct-4-en-1-ol, (S~1~R)-3-carbamoyl-4-methoxybenzene-1-sulfinic acid, Histidine-covalent stapled alpha-helical peptide, ... | | 著者 | Muzzarelli, K.M, Assar, Z, Alboreggia, G, Pellecchia, M. | | 登録日 | 2024-01-07 | | 公開日 | 2024-05-15 | | 最終更新日 | 2024-06-05 | | 実験手法 | X-RAY DIFFRACTION (1.13 Å) | | 主引用文献 | Histidine-Covalent Stapled Alpha-Helical Peptides Targeting hMcl-1.
J.Med.Chem., 67, 2024
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6VBX
 | | Crystal structure of Mcl-1 in complex with 138E12 peptide, Lys-covalent antagonist | | 分子名称: | Induced myeloid leukemia cell differentiation protein Mcl-1, Synthetic peptide | | 著者 | Pellecchia, M, Perry, J.J, Kenjic, N, Assar, Z. | | 登録日 | 2019-12-19 | | 公開日 | 2020-12-30 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Design, Synthesis, and Structural Characterization of Lysine Covalent BH3 Peptides Targeting Mcl-1.
J.Med.Chem., 64, 2021
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