3FWO
| The large ribosomal subunit from Deinococcus radiodurans complexed with Methymycin | 分子名称: | (3R,4S,5S,7R,9E,11S,12R)-12-ethyl-11-hydroxy-3,5,7,11-tetramethyl-2,8-dioxooxacyclododec-9-en-4-yl 3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranoside, 23S RIBOSOMAL RNA, 5S RIBOSOMAL RNA | 著者 | Auerbach, T, Mermershtain, I, Bashan, A, Davidovich, C, Rozenberg, H, Sherman, D.H, Yonath, A. | 登録日 | 2009-01-19 | 公開日 | 2010-01-19 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (3.71 Å) | 主引用文献 | Structural basis for the antibacterial activity of the 12-membered-ring mono-sugar macrolide methymycin Biotechnologia, 1, 2009
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6GVB
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3LXG
| Crystal structure of rat phosphodiesterase 10A in complex with ligand WEB-3 | 分子名称: | 2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrido[3,2-e]pyrazine, MAGNESIUM ION, ZINC ION, ... | 著者 | Mosbacher, T, Jestel, A, Steinbacher, S. | 登録日 | 2010-02-25 | 公開日 | 2010-05-19 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Discovery of imidazo[1,5-a]pyrido[3,2-e]pyrazines as a new class of phosphodiesterase 10A inhibitiors. J.Med.Chem., 53, 2010
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6SLO
| Crystal structure of PUF60 UHM domain in complex with 7,8 dimethoxyperphenazine | 分子名称: | 2-[4-[3-(8-chloranyl-2,3-dimethoxy-phenothiazin-10-yl)propyl]piperazin-1-yl]ethanol, MAGNESIUM ION, Thioredoxin,Poly(U)-binding-splicing factor PUF60 | 著者 | Jagtap, P.K.A, Kubelka, T, Bach, T, Sattler, M. | 登録日 | 2019-08-20 | 公開日 | 2020-09-09 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | Identification of phenothiazine derivatives as UHM-binding inhibitors of early spliceosome assembly. Nat Commun, 11, 2020
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7Z2U
| Wild-type ferulic acid esterase from Lactobacillus buchneri in complex with ferulate | 分子名称: | 3-(4-HYDROXY-3-METHOXYPHENYL)-2-PROPENOIC ACID, CALCIUM ION, Ferulic acid esterase | 著者 | Mogodiniyai, K.K, Reichenbach, T, Kalyani, D.C, Keskitalo, M.M, Divne, C. | 登録日 | 2022-02-28 | 公開日 | 2022-11-30 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal structure of the feruloyl esterase from Lentilactobacillus buchneri reveals a novel homodimeric state. Front Microbiol, 13, 2022
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7Z2V
| Ferulic acid esterase variant S114A from Lactobacillus buchneri | 分子名称: | ACETATE ION, CALCIUM ION, Ferulic acid esterase | 著者 | Mogodiniyai, K.K, Reichenbach, T, Kalyani, D.C, Keskitalo, M.M, Divne, C. | 登録日 | 2022-02-28 | 公開日 | 2022-11-30 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Crystal structure of the feruloyl esterase from Lentilactobacillus buchneri reveals a novel homodimeric state. Front Microbiol, 13, 2022
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7Z2X
| Wild-type ferulic acid esterase from Lactobacillus buchneri | 分子名称: | Ferulic acid esterase | 著者 | Mogodiniyai, K.K, Reichenbach, T, Kalyani, D.C, Keskitalo, M.M, Divne, C. | 登録日 | 2022-03-01 | 公開日 | 2022-11-30 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Crystal structure of the feruloyl esterase from Lentilactobacillus buchneri reveals a novel homodimeric state. Front Microbiol, 13, 2022
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3SNL
| Highly Potent, Selective, and Orally Active Phosphodiestarase 10A Inhibitors | 分子名称: | 6-chloro-3,4-dimethyl-1-(3-methylpyridin-4-yl)-8-(trifluoromethyl)imidazo[1,5-a]quinoxaline, MAGNESIUM ION, ZINC ION, ... | 著者 | Malamas, M.S, Ni, Y, Erdei, J, Stange, H, Schindler, R, Lankau, H.-J, Grunwald, C, Fan, K.Y, Parris, K.D, Langen, B, Egerland, U, Hage, T, Marquis, K.L, Grauer, S, Brennan, J, Navarra, R, Graf, R, Harrison, B.L, Robichaud, A, Kronbach, T, Pangalos, M, Hofgen, N, Brandon, N.J. | 登録日 | 2011-06-29 | 公開日 | 2011-10-26 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Highly Potent, Selective, and Orally Active Phosphodiesterase 10A Inhibitors. J.Med.Chem., 54, 2011
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3SNI
| Highly Potent, Selective, and Orally Active Phosphodiestarase 10A Inhibitors | 分子名称: | 2-methoxy-6,7-dimethyl-9-(4-methylpyridin-3-yl)imidazo[1,5-a]pyrido[3,2-e]pyrazine, CHLORIDE ION, MAGNESIUM ION, ... | 著者 | Malamas, M.S, Ni, Y, Erdei, J, Stange, H, Schindler, R, Lankau, H.-J, Grunwald, C, Fan, K.Y, Parris, K.D, Langen, B, Egerland, U, Hage, T, Marquis, K.L, Grauer, S, Brennan, J, Navarra, R, Graf, R, Harrison, B.L, Robichaud, A, Kronbach, T, Pangalos, M, Hofgen, N, Brandon, N.J. | 登録日 | 2011-06-29 | 公開日 | 2011-10-26 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Highly Potent, Selective, and Orally Active Phosphodiesterase 10A Inhibitors. J.Med.Chem., 54, 2011
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7BOB
| Exo-beta-1,4-mannosidase Op5Man5 from Opitutaceae bacterium strain TAV5 | 分子名称: | Endo-beta-mannanase | 著者 | Kalyani, D.C, Reichenbach, T, Keskitalo, M.M, Conrad, J, Aspeborg, H, Divne, C. | 登録日 | 2021-01-24 | 公開日 | 2021-07-14 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal structure of a homotrimeric verrucomicrobial exo - beta -1,4-mannosidase active in the hindgut of the wood-feeding termite Reticulitermes flavipes . J Struct Biol X, 5, 2021
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1EPU
| X-RAY crystal structure of neuronal SEC1 from squid | 分子名称: | S-SEC1 | 著者 | Bracher, A, Perrakis, A, Dresbach, T, Betz, H, Weissenhorn, W. | 登録日 | 2000-03-29 | 公開日 | 2000-08-09 | 最終更新日 | 2017-10-04 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | The X-ray crystal structure of neuronal Sec1 from squid sheds new light on the role of this protein in exocytosis. Structure Fold.Des., 8, 2000
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6ZB9
| Exo-beta-1,3-glucanase from moose rumen microbiome, wild type | 分子名称: | Exo-beta-1,3-glucanase | 著者 | Kalyani, D.C, Reichenbach, T, Aspeborg, H, Divne, C. | 登録日 | 2020-06-08 | 公開日 | 2021-01-13 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | A homodimeric bacterial exo-beta-1,3-glucanase derived from moose rumen microbiome shows a structural framework similar to yeast exo-beta-1,3-glucanases. Enzyme.Microb.Technol., 143, 2021
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6ZB8
| Exo-beta-1,3-glucanase from moose rumen microbiome, active site mutant E167Q/E295Q | 分子名称: | Exo-beta-1,3-glucanase variant E167Q/E295Q, POLYETHYLENE GLYCOL (N=34) | 著者 | Kalyani, D.C, Reichenbach, T, Aspeborg, H, Divne, C. | 登録日 | 2020-06-08 | 公開日 | 2021-01-13 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | A homodimeric bacterial exo-beta-1,3-glucanase derived from moose rumen microbiome shows a structural framework similar to yeast exo-beta-1,3-glucanases. Enzyme.Microb.Technol., 143, 2021
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5MLZ
| Dolichyl phosphate mannose synthase in complex with GDP and Mg2+ | 分子名称: | CHLORIDE ION, Dolichol monophosphate mannose synthase, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Gandini, R, Reichenbach, T, Tan, T.C, Divne, C. | 登録日 | 2016-12-08 | 公開日 | 2017-08-09 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural basis for dolichylphosphate mannose biosynthesis. Nat Commun, 8, 2017
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5MM0
| Dolichyl phosphate mannose synthase in complex with GDP-mannose and Mn2+ (donor complex) | 分子名称: | CHLORIDE ION, Dolichol monophosphate mannose synthase, GUANOSINE-5'-DIPHOSPHATE-ALPHA-D-MANNOSE, ... | 著者 | Gandini, R, Reichenbach, T, Tan, T.C, Divne, C. | 登録日 | 2016-12-08 | 公開日 | 2017-08-09 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural basis for dolichylphosphate mannose biosynthesis. Nat Commun, 8, 2017
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5MM1
| Dolichyl phosphate mannose synthase in complex with GDP and dolichyl phosphate mannose | 分子名称: | Dolichol monophosphate mannose synthase, GUANOSINE-5'-DIPHOSPHATE, dolichyl phosphate mannose | 著者 | Gandini, R, Reichenbach, T, Tan, T.C, Divne, C. | 登録日 | 2016-12-08 | 公開日 | 2017-08-09 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural basis for dolichylphosphate mannose biosynthesis. Nat Commun, 8, 2017
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1OND
| THE CRYSTAL STRUCTURE OF THE 50S LARGE RIBOSOMAL SUBUNIT FROM DEINOCOCCUS RADIODURANS COMPLEXED WITH TROLEANDOMYCIN MACROLIDE ANTIBIOTIC | 分子名称: | 23S RIBOSOMAL RNA, 50S ribosomal protein L22, 50S ribosomal protein L32, ... | 著者 | Berisio, R, Schluenzen, F, Harms, J, Bashan, A, Auerbach, T, Baram, D, Yonath, A. | 登録日 | 2003-02-27 | 公開日 | 2003-04-15 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | Structural insight into the role of the ribosomal tunnel in cellular regulation Nat.Struct.Biol., 10, 2003
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3JQ4
| The structure of the complex of the large ribosomal subunit from D. Radiodurans with the antibiotic lankacidin | 分子名称: | 23S ribosomal RNA, 5S ribosomal RNA, N-[(1S,2R,3E,5E,7S,9E,11E,13S,15R,19R)-7,13-dihydroxy-1,4,10,19-tetramethyl-17,18-dioxo-16-oxabicyclo[13.2.2]nonadeca-3,5,9,11-tetraen-2-yl]-2-oxopropanamide | 著者 | Auerbach-Nevo, T, Mermershtain, I, Davidovich, C, Bashan, A, Rozenberg, H, Yonath, A. | 登録日 | 2009-09-06 | 公開日 | 2010-09-08 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (3.52 Å) | 主引用文献 | The structure of ribosome-lankacidin complex reveals ribosomal sites for synergistic antibiotics Proc.Natl.Acad.Sci.USA, 107, 2010
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2MK1
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5ZZD
| Crystal structure of a protein from Aspergillus flavus | 分子名称: | O-methyltransferase lepI, S-ADENOSYLMETHIONINE | 著者 | Chang, Z.Y, Liu, W.D, Chen, C.C, Guo, R.T. | 登録日 | 2018-05-31 | 公開日 | 2019-06-05 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Crystal structure of LepI, a multifunctional SAM-dependent enzyme which catalyzes pericyclic reactions in leporin biosynthesis. Org.Biomol.Chem., 17, 2019
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6B0Z
| IDH1 R132H mutant in complex with IDH305 | 分子名称: | (4R)-4-[(1S)-1-fluoroethyl]-3-[2-({(1S)-1-[4-methyl-2'-(trifluoromethyl)[3,4'-bipyridin]-6-yl]ethyl}amino)pyrimidin-4-yl]-1,3-oxazolidin-2-one, CITRATE ANION, Isocitrate dehydrogenase [NADP] cytoplasmic, ... | 著者 | Xie, X, Kulathila, R. | 登録日 | 2017-09-15 | 公開日 | 2017-11-08 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.334 Å) | 主引用文献 | Discovery and Evaluation of Clinical Candidate IDH305, a Brain Penetrant Mutant IDH1 Inhibitor. ACS Med Chem Lett, 8, 2017
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1FVF
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1FVH
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8CAA
| Crystal structure of TEAD4 in complex with YTP-13 | 分子名称: | (2~{R})-2-[2-chloranyl-5-[2-chloranyl-4-(trifluoromethyl)phenoxy]phenyl]sulfanylpropanoic acid, 4-[bis(fluoranyl)methoxy]-2-[(2~{S})-5-chloranyl-6-fluoranyl-2-[[(4-oxidanylcyclohexyl)amino]methyl]-2-phenyl-3~{H}-1-benzofuran-4-yl]-3-fluoranyl-benzamide, PHOSPHATE ION, ... | 著者 | Scheufler, C, Kallen, J. | 登録日 | 2023-01-24 | 公開日 | 2023-04-12 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (1.999 Å) | 主引用文献 | Optimization of a Class of Dihydrobenzofurane Analogs toward Orally Efficacious YAP-TEAD Protein-Protein Interaction Inhibitors. Chemmedchem, 18, 2023
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3SN7
| Highly Potent, Selective, and Orally Active Phosphodiestarase 10A Inhibitors | 分子名称: | 8-fluoro-6-methoxy-3,4-dimethyl-1-(3-methylpyridin-4-yl)imidazo[1,5-a]quinoxaline, CHLORIDE ION, MAGNESIUM ION, ... | 著者 | Parris, K.D. | 登録日 | 2011-06-28 | 公開日 | 2011-10-26 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | 主引用文献 | Highly Potent, Selective, and Orally Active Phosphodiesterase 10A Inhibitors. J.Med.Chem., 54, 2011
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