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3LXG

Crystal structure of rat phosphodiesterase 10A in complex with ligand WEB-3

Summary for 3LXG
Entry DOI10.2210/pdb3lxg/pdb
DescriptorcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, 2-methoxy-6,7-dimethyl-9-propylimidazo[1,5-a]pyrido[3,2-e]pyrazine, ZINC ION, ... (5 entities in total)
Functional Keywordsphosphodiesterase 10a; catalytic domain, allosteric enzyme, camp, camp-binding, cgmp, cgmp-binding, hydrolase, metal-binding, nucleotide-binding
Biological sourceRattus norvegicus (rat)
Cellular locationCytoplasm: Q9QYJ6
Total number of polymer chains1
Total formula weight36033.09
Authors
Mosbacher, T.,Jestel, A.,Steinbacher, S. (deposition date: 2010-02-25, release date: 2010-05-19, Last modification date: 2024-02-21)
Primary citationHofgen, N.,Stange, H.,Schindler, R.,Lankau, H.J.,Grunwald, C.,Langen, B.,Egerland, U.,Tremmel, P.,Pangalos, M.N.,Marquis, K.L.,Hage, T.,Harrison, B.L.,Malamas, M.S.,Brandon, N.J.,Kronbach, T.
Discovery of imidazo[1,5-a]pyrido[3,2-e]pyrazines as a new class of phosphodiesterase 10A inhibitiors.
J.Med.Chem., 53:4399-4411, 2010
Cited by
PubMed: 20450197
DOI: 10.1021/jm1002793
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.3 Å)
Structure validation

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