3LXG

Crystal structure of rat phosphodiesterase 10A in complex with ligand WEB-3

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
A	0007165	biological_process	signal transduction
A	0008081	molecular_function	phosphoric diester hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE Z73 A 1

Chain	Residue
A	HOH18
A	PHE719
A	TYR514
A	LEU665
A	SER667
A	VAL668
A	ILE682
A	PHE686
A	MET703
A	GLN716

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 761

Chain	Residue
A	HOH111
A	HIS519
A	HIS553
A	ASP554
A	ASP664

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 2

Chain	Residue
A	HOH104
A	HOH108
A	HOH109
A	HOH110
A	HOH111
A	ASP554

---

Functional Information from PROSITE/UniProt

site_id	PS00126
Number of Residues	12
Details	PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHrGfsNsY

Chain	Residue	Details
A	HIS553-TYR564

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton donor => ECO:0000250|UniProtKB:O76083

Chain	Residue	Details
A	HIS515

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q9Y233

Chain	Residue	Details
A	HIS515
A	GLN716

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:17228859

Chain	Residue	Details
A	HIS519
A	HIS553
A	ASP554
A	ASP664

---