3FWO

The large ribosomal subunit from Deinococcus radiodurans complexed with Methymycin

Summary for 3FWO

• Entry DOI: 10.2210/pdb3fwo/pdb
• Related: 1NKW
• Descriptor: 23S RIBOSOMAL RNA, 5S RIBOSOMAL RNA, (3R,4S,5S,7R,9E,11S,12R)-12-ethyl-11-hydroxy-3,5,7,11-tetramethyl-2,8-dioxooxacyclododec-9-en-4-yl 3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranoside (3 entities in total)
• Functional Keywords: ribosome; large subunit; 50s; deinococcus radiodurans; x-ray structure; peptidyl-transferase, peptide bond formation, antibiotics, macrolides, ribosome
• Biological source: Deinococcus radiodurans R1; More
• Total number of polymer chains: 2
• Total formula weight: 971904.39

Authors

Auerbach, T.,Mermershtain, I.,Bashan, A.,Davidovich, C.,Rozenberg, H.,Sherman, D.H.,Yonath, A. (deposition date: 2009-01-19, release date: 2010-01-19, Last modification date: 2024-02-21)

• Primary citation: Auerbach, T.,Mermershtain, I.,Bashan, A.,Davidovich, C.,Rozenberg, H.,Sherman, D.H.,Yonath, A.; Structural basis for the antibacterial activity of the 12-membered-ring mono-sugar macrolide methymycin; Biotechnologia, 1:24-35, 2009

Experimental method

X-RAY DIFFRACTION (3.71 Å)