3SN7

Highly Potent, Selective, and Orally Active Phosphodiestarase 10A Inhibitors

Summary for 3SN7

Entry DOI	10.2210/pdb3sn7/pdb
Related	3SNI 3SNL
Descriptor	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, CHLORIDE ION, 8-fluoro-6-methoxy-3,4-dimethyl-1-(3-methylpyridin-4-yl)imidazo[1,5-a]quinoxaline, ... (6 entities in total)
Functional Keywords	hydrolase, hydrolase inhibitor, zn binding, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: Q9Y233
Total number of polymer chains	2
Total formula weight	80135.92
Authors	Parris, K.D. (deposition date: 2011-06-28, release date: 2011-10-26, Last modification date: 2024-02-28)
Primary citation	Malamas, M.S.,Ni, Y.,Erdei, J.,Stange, H.,Schindler, R.,Lankau, H.J.,Grunwald, C.,Fan, K.Y.,Parris, K.,Langen, B.,Egerland, U.,Hage, T.,Marquis, K.L.,Grauer, S.,Brennan, J.,Navarra, R.,Graf, R.,Harrison, B.L.,Robichaud, A.,Kronbach, T.,Pangalos, M.N.,Hoefgen, N.,Brandon, N.J. Highly Potent, Selective, and Orally Active Phosphodiesterase 10A Inhibitors. J.Med.Chem., 54:7621-7638, 2011 Cited by PubMed: 21988093 DOI: 10.1021/jm2009138 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.82 Å)

Structure validation