3SN7
Highly Potent, Selective, and Orally Active Phosphodiestarase 10A Inhibitors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | polymer | 345 | 39606.4 | 2 | UniProt (Q9Y233) | Homo sapiens (human) | |
| 2 | C, G (A, B) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 3 | D, H (A, B) | 8-fluoro-6-methoxy-3,4-dimethyl-1-(3-methylpyridin-4-yl)imidazo[1,5-a]quinoxaline | non-polymer | 336.4 | 2 | Chemie (540) | |||
| 4 | E, I (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 5 | F, J (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 6 | K, L (A, B) | water | water | 18.0 | 256 | Chemie (HOH) |
Sequence modifications
A, B: 439 - 779 (UniProt: Q9Y233)
| PDB | External Database | Details |
|---|---|---|
| Gly 435 | - | expression tag |
| Ser 436 | - | expression tag |
| His 437 | - | expression tag |
| Met 438 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 79212.9 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 923.1 | |
| All* | Total formula weight | 80135.9 |
