1N3G
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1FKM
| CRYSTAL STRUCTURE OF THE YPT/RAB-GAP DOMAIN OF GYP1P | 分子名称: | PROTEIN (GYP1P) | 著者 | Rak, A, Fedorov, R, Alexandrov, K, Albert, S, Goody, R.S, Gallwitz, D, Scheidig, A.J. | 登録日 | 2000-08-09 | 公開日 | 2001-02-09 | 最終更新日 | 2022-12-21 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal structure of the GAP domain of Gyp1p: first insights into interaction with Ypt/Rab proteins. EMBO J., 19, 2000
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1VG1
| GDP-Bound Rab7 | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Ras-related protein Rab-7 | 著者 | Rak, A, Pylypenko, O, Niculae, A, Pyatkov, K, Goody, R.S, Alexandrov, K. | 登録日 | 2004-04-22 | 公開日 | 2004-07-20 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structure of the Rab7:REP-1 complex: insights into the mechanism of Rab prenylation and choroideremia disease Cell(Cambridge,Mass.), 117, 2004
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1VG8
| GPPNHP-Bound Rab7 | 分子名称: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Ras-related protein Rab-7 | 著者 | Rak, A, Pylypenko, O, Niculae, A, Pyatkov, K, Goody, R.S, Alexandrov, K. | 登録日 | 2004-04-23 | 公開日 | 2004-07-20 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structure of the Rab7:REP-1 complex: insights into the mechanism of Rab prenylation and choroideremia disease Cell(Cambridge,Mass.), 117, 2004
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1VG9
| The crystal structures of the REP-1 protein in complex with C-terminally truncated Rab7 protein | 分子名称: | 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Rak, A, Pylypenko, O, Niculae, A, Pyatkov, K, Goody, R.S, Alexandrov, K. | 登録日 | 2004-04-23 | 公開日 | 2004-07-20 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structure of the Rab7:REP-1 complex: insights into the mechanism of Rab prenylation and choroideremia disease Cell(Cambridge,Mass.), 117, 2004
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1VG0
| The crystal structures of the REP-1 protein in complex with monoprenylated Rab7 protein | 分子名称: | CHLORIDE ION, GERAN-8-YL GERAN, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Rak, A, Pylypenko, O, Niculae, A, Pyatkov, K, Goody, R.S, Alexandrov, K. | 登録日 | 2004-04-22 | 公開日 | 2004-07-20 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structure of the Rab7:REP-1 complex: insights into the mechanism of Rab prenylation and choroideremia disease Cell(Cambridge,Mass.), 117, 2004
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1UKV
| Structure of RabGDP-dissociation inhibitor in complex with prenylated YPT1 GTPase | 分子名称: | GERAN-8-YL GERAN, GTP-binding protein YPT1, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Rak, A, Pylypenko, O, Durek, T, Watzke, A, Kushnir, S, Brunsveld, L, Waldmann, H, Goody, R.S, Alexandrov, K. | 登録日 | 2003-09-01 | 公開日 | 2004-09-01 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Structure of Rab GDP-dissociation inhibitor in complex with prenylated YPT1 GTPase Science, 302, 2003
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1CTN
| CRYSTAL STRUCTURE OF A BACTERIAL CHITINASE AT 2.3 ANGSTROMS RESOLUTION | 分子名称: | CHITINASE A | 著者 | Perrakis, A, Tews, I, Dauter, Z, Wilson, K.S, Vorgias, C.E. | 登録日 | 1994-10-10 | 公開日 | 1995-02-07 | 最終更新日 | 2019-08-14 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal structure of a bacterial chitinase at 2.3 A resolution. Structure, 2, 1994
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4MB7
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4NRW
| MvNei1-G86D | 分子名称: | 5'-D(*CP*GP*TP*CP*CP*AP*(3DR)P*GP*TP*CP*TP*AP*C)-3', 5'-D(*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*G)-3', formamidopyrimidine-DNA glycosylase | 著者 | Prakash, A, Doublie, S. | 登録日 | 2013-11-27 | 公開日 | 2014-01-01 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.845 Å) | 主引用文献 | Genome and cancer single nucleotide polymorphisms of the human NEIL1 DNA glycosylase: Activity, structure, and the effect of editing. Dna Repair, 14, 2014
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4NRV
| Crystal Structure of non-edited human NEIL1 | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Endonuclease 8-like 1 | 著者 | Prakash, A, Doublie, S. | 登録日 | 2013-11-27 | 公開日 | 2014-01-01 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.601 Å) | 主引用文献 | Genome and cancer single nucleotide polymorphisms of the human NEIL1 DNA glycosylase: Activity, structure, and the effect of editing. Dna Repair, 14, 2014
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3A8Y
| Crystal structure of the complex between the BAG5 BD5 and Hsp70 NBD | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BAG family molecular chaperone regulator 5, Heat shock 70 kDa protein 1 | 著者 | Arakawa, A, Handa, N, Ohsawa, N, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2009-10-13 | 公開日 | 2010-03-31 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | The C-terminal BAG domain of BAG5 induces conformational changes of the Hsp70 nucleotide-binding domain for ADP-ATP exchange Structure, 18, 2010
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3ATV
| Crystal structure of human Hsp70 NBD in the ADP-bound and Mg ion-free state | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, Heat shock 70 kDa protein 1A/1B, ... | 著者 | Arakawa, A, Handa, N, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2011-01-13 | 公開日 | 2011-12-28 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | 主引用文献 | Biochemical and structural studies on the high affinity of Hsp70 for ADP. Protein Sci., 20, 2011
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3ATU
| Crystal structure of human Hsp70 NBD in the ADP- and Mg ion-bound state | 分子名称: | 2-(2-METHOXYETHOXY)ETHANOL, ADENOSINE-5'-DIPHOSPHATE, Heat shock 70 kDa protein 1A/1B, ... | 著者 | Arakawa, A, Handa, N, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2011-01-13 | 公開日 | 2011-12-28 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Biochemical and structural studies on the high affinity of Hsp70 for ADP. Protein Sci., 20, 2011
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3AY9
| Crystal structure of human Hsp70 NBD in the ADP-, Mg ion-, and K ion-bound state | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, CHLORIDE ION, ... | 著者 | Arakawa, A, Handa, N, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2011-05-03 | 公開日 | 2011-12-28 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Biochemical and structural studies on the high affinity of Hsp70 for ADP. Protein Sci., 20, 2011
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8BW0
| Structure of CEACAM5 A3-B3 domain in Complex with Tusamitamab Fab | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Carcinoembryonic antigen-related cell adhesion molecule 5, ... | 著者 | Kumar, A, Bertrand, T, Rapisarda, C, Rak, A. | 登録日 | 2022-12-06 | 公開日 | 2024-01-24 | 実験手法 | ELECTRON MICROSCOPY (3.11 Å) | 主引用文献 | Structural insights into epitope-paratope interactions of monoclonal antibody targeting CEACAM5-expressing tumors Res Sq, 2023
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6QCG
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8ARF
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2MPH
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7BFZ
| X-ray structure of human prostate-specific membrane antigen(PSMA) in complex with a inhibitor Glu-490 | 分子名称: | (((S)-1-carboxy-5-((E)-2-cyano-3-(5-(1-(3-methoxy-3-oxopropyl)-1,2,3,4-tetrahydroquinolin-6-yl)thiophen-2-yl)acrylamido)pentyl)carbamoyl)-L-glutamic acid, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Rakhimbekova, A, Motlova, L, Barinka, C. | 登録日 | 2021-01-05 | 公開日 | 2021-08-18 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | 主引用文献 | A prostate-specific membrane antigen activated molecular rotor for real-time fluorescence imaging. Nat Commun, 12, 2021
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5D75
| Crystal structure of Human FKBD25 in complex with FK506 | 分子名称: | 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN, O-(O-(2-AMINOPROPYL)-O'-(2-METHOXYETHYL)POLYPROPYLENE GLYCOL 500), Peptidyl-prolyl cis-trans isomerase FKBP3 | 著者 | Rajan, S, Prakash, A, Yoon, H.S. | 登録日 | 2015-08-13 | 公開日 | 2016-04-06 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | 主引用文献 | Crystal structure of the FK506 binding domain of human FKBP25 in complex with FK506. Protein Sci., 25, 2016
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4UUQ
| Crystal structure of human mono-glyceride lipase in complex with SAR127303 | 分子名称: | 4-({[(4-chlorophenyl)sulfonyl]amino}methyl)piperidine-1-carboxylic acid, MONOGLYCERIDE LIPASE | 著者 | Griebel, G, Pichat, P, Beeske, S, Leroy, T, Redon, N, Francon, D, Bert, L, Even, L, Lopez-Grancha, M, Tolstykh, T, Sun, F, Yu, Q, Brittain, S, Arlt, H, He, T, Zhang, B, Wiederschain, D, Bertrand, T, Houtman, J, Rak, A, Vallee, F, Michot, N, Auge, F, Menet, V, Bergis, O.E, George, P, Avenet, P, Mikol, V, Didier, M, Escoubet, J. | 登録日 | 2014-07-30 | 公開日 | 2015-01-21 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.36 Å) | 主引用文献 | Selective Blockade of the Hydrolysis of the Endocannabinoid 2-Arachidonoylglycerol Impairs Learning and Memory Performance While Producing Antinociceptive Activity in Rodents. Sci.Rep., 5, 2015
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1AB3
| RIBOSOMAL PROTEIN S15 FROM THERMUS THERMOPHILUS, NMR, 26 STRUCTURES | 分子名称: | RIBOSOMAL RNA BINDING PROTEIN S15 | 著者 | Berglund, H, Rak, A, Serganov, A, Garber, M, Hard, T. | 登録日 | 1997-02-03 | 公開日 | 1997-04-01 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of the ribosomal RNA binding protein S15 from Thermus thermophilus. Nat.Struct.Biol., 4, 1997
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1LTX
| Structure of Rab Escort Protein-1 in complex with Rab geranylgeranyl transferase and isoprenoid | 分子名称: | AAAA, CHLORIDE ION, FARNESYL, ... | 著者 | Pylypenko, O, Rak, A, Reents, R, Niculae, A, Thoma, N.H, Waldmann, H, Schlichting, I, Goody, R.S, Alexandrov, K. | 登録日 | 2002-05-21 | 公開日 | 2003-05-21 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structure of Rab Escort Protein-1 in Complex with Rab Geranylgeranyltransferase Mol.Cell, 11, 2003
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6SBO
| Estrogen receptor mutant L536S | 分子名称: | 6-(2,4-dichlorophenyl)-5-[4-[(3~{S})-1-(3-fluoranylpropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7~{H}-benzo[7]annulene-2-carboxylic acid, Estrogen receptor | 著者 | Vallee, F, Steier, V, Rak, A. | 登録日 | 2019-07-22 | 公開日 | 2019-11-27 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | 主引用文献 | Discovery of 6-(2,4-Dichlorophenyl)-5-[4-[(3S)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7H-benzo[7]annulene-2-carboxylic acid (SAR439859), a Potent and Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen-Receptor-Positive Breast Cancer. J.Med.Chem., 63, 2020
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