3BSU
| Hybrid-binding domain of human RNase H1 in complex with 12-mer RNA/DNA | 分子名称: | DNA (5'-D(*DGP*DAP*DAP*DTP*DCP*DAP*DGP*DGP*(5IU)P*DGP*DTP*DC)-3'), MAGNESIUM ION, RNA (5'-R(*GP*AP*CP*AP*CP*CP*UP*GP*AP*UP*UP*C)-3'), ... | 著者 | Nowotny, M, Cerritelli, S.M, Ghirlando, R, Gaidamakov, S.A, Crouch, R.J, Yang, W. | 登録日 | 2007-12-26 | 公開日 | 2008-03-25 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Specific recognition of RNA/DNA hybrid and enhancement of human RNase H1 activity by HBD. Embo J., 27, 2008
|
|
1ZBL
| Bacillus halodurans RNase H catalytic domain mutant D192N in complex with 12-mer RNA/DNA hybrid | 分子名称: | 5'-D(*GP*AP*AP*TP*CP*AP*GP*GP*TP*GP*TP*C)-3', 5'-R(*GP*AP*CP*AP*CP*CP*UP*GP*AP*UP*UP*C)-3', MAGNESIUM ION, ... | 著者 | Nowotny, M, Gaidamakov, S.A, Crouch, R.J, Yang, W. | 登録日 | 2005-04-08 | 公開日 | 2005-07-12 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal Structures of RNase H Bound to an RNA/DNA Hybrid: Substrate Specificity and Metal-Dependent Catalysis. Cell(Cambridge,Mass.), 121, 2005
|
|
1ZBI
| Bacillus halodurans RNase H catalytic domain mutant D132N in complex with 12-mer RNA/DNA hybrid | 分子名称: | 5'-D(*GP*AP*AP*TP*CP*AP*GP*GP*TP*GP*TP*C)-3', 5'-R(*GP*AP*CP*AP*CP*CP*UP*GP*AP*UP*UP*C)-3', MAGNESIUM ION, ... | 著者 | Nowotny, M, Gaidamakov, S.A, Crouch, R.J, Yang, W. | 登録日 | 2005-04-08 | 公開日 | 2005-07-12 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Crystal Structures of RNase H Bound to an RNA/DNA Hybrid: Substrate Specificity and Metal-Dependent Catalysis. Cell(Cambridge,Mass.), 121, 2005
|
|
1ZBF
| Crystal structure of B. halodurans RNase H catalytic domain mutant D132N | 分子名称: | SULFATE ION, ribonuclease H-related protein | 著者 | Nowotny, M, Gaidamakov, S.A, Crouch, R.J, Yang, W. | 登録日 | 2005-04-08 | 公開日 | 2005-07-12 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Crystal Structures of RNase H Bound to an RNA/DNA Hybrid: Substrate Specificity and Metal-Dependent Catalysis. Cell(Cambridge,Mass.), 121, 2005
|
|
2QK9
| Human RNase H catalytic domain mutant D210N in complex with 18-mer RNA/DNA hybrid | 分子名称: | 5'-D(*GP*GP*AP*AP*TP*CP*AP*GP*GP*TP*GP*TP*CP*GP*CP*AP*CP*T)-3', 5'-R(*AP*GP*UP*GP*CP*GP*AP*CP*AP*CP*CP*UP*GP*AP*UP*UP*CP*C)-3', CITRATE ANION, ... | 著者 | Nowotny, M, Gaidamakov, S.A, Ghirlando, R, Cerritelli, S.M, Crouch, R.J, Yang, W. | 登録日 | 2007-07-10 | 公開日 | 2007-11-13 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Structure of Human RNase H1 Complexed with an RNA/DNA Hybrid: Insight into HIV Reverse Transcription Mol.Cell, 28, 2007
|
|
2QKB
| Human RNase H catalytic domain mutant D210N in complex with 20-mer RNA/DNA hybrid | 分子名称: | 1,2-ETHANEDIOL, 5'-D(*DGP*DGP*DAP*DAP*DTP*DCP*DAP*DGP*DGP*DTP*DGP*DTP*DCP*DGP*DCP*DAP*DCP*DTP*DCP*DT)-3', 5'-R(*GP*GP*AP*GP*UP*GP*CP*GP*AP*CP*AP*CP*CP*UP*GP*AP*UP*UP*CP*C)-3'), ... | 著者 | Nowotny, M, Gaidamakov, S.A, Ghirlando, R, Cerritelli, S.M, Crouch, R.J, Yang, W. | 登録日 | 2007-07-10 | 公開日 | 2007-11-13 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structure of Human RNase H1 Complexed with an RNA/DNA Hybrid: Insight into HIV Reverse Transcription Mol.Cell, 28, 2007
|
|
2QKK
| Human RNase H catalytic domain mutant D210N in complex with 14-mer RNA/DNA hybrid | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 5'-D(*GP*GP*AP*AP*TP*CP*AP*GP*GP*TP*GP*TP*CP*G)-3', ... | 著者 | Nowotny, M, Gaidamakov, S.A, Ghirlando, R, Cerritelli, S.M, Crouch, R.J, Yang, W. | 登録日 | 2007-07-11 | 公開日 | 2007-11-13 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Structure of Human RNase H1 Complexed with an RNA/DNA Hybrid: Insight into HIV Reverse Transcription Mol.Cell, 28, 2007
|
|
2G8I
| |
2G8W
| |
2G8K
| |
2G8H
| |
2G8F
| |
2G8U
| |
2G8V
| |
7O24
| |
6ZE8
| Crystal structure of human chitotriosidase-1 (hCHIT) catalytic domain in complex with compound OATD-01 | 分子名称: | 5-(4-((2S,5S)-5-(4-chlorobenzyl)-2-methylmorpholino)piperidin-1-yl)-4H-1,2,4-triazol-3-amine, Chitotriosidase-1, GLYCEROL, ... | 著者 | Nowotny, M, Bartlomiejczak, A, Napiorkowska-Gromadzka, A. | 登録日 | 2020-06-16 | 公開日 | 2020-11-11 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Discovery of OATD-01 , a First-in-Class Chitinase Inhibitor as Potential New Therapeutics for Idiopathic Pulmonary Fibrosis. J.Med.Chem., 63, 2020
|
|
7Z0Z
| Abortive infection DNA polymerase AbiK from Lactococcus lactis, Y44F variant | 分子名称: | AbiK | 著者 | Figiel, M, Gapinska, M, Czarnocki-Cieciura, M, Zajko, W, Nowotny, M. | 登録日 | 2022-02-24 | 公開日 | 2022-09-07 | 最終更新日 | 2022-10-05 | 実験手法 | ELECTRON MICROSCOPY (2.68 Å) | 主引用文献 | Mechanism of protein-primed template-independent DNA synthesis by Abi polymerases. Nucleic Acids Res., 50, 2022
|
|
5J5O
| Translation initiation factor 4E in complex with m7GppppG mRNA 5' cap analog | 分子名称: | 5'-O-[(R)-hydroxy{[(R)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]oxy}phosphoryl]-7-methylguanosine, Eukaryotic translation initiation factor 4E, GLYCEROL | 著者 | Warminski, M, Nowak, E, Rydzik, A.M, Kowalska, J, Jemielity, J, Nowotny, M. | 登録日 | 2016-04-03 | 公開日 | 2017-05-10 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.867 Å) | 主引用文献 | mRNA cap analogues substituted in the tetraphosphate chain with CX2: identification of O-to-CCl2 as the first bridging modification that confers resistance to decapping without impairing translation. Nucleic Acids Res., 45, 2017
|
|
4N4A
| Cystal structure of Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 | 分子名称: | Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 | 著者 | Smietanski, M, Werener, M, Purta, E, Kaminska, K.H, Stepinski, J, Darzynkiewicz, E, Nowotny, M, Bujnicki, J.M. | 登録日 | 2013-10-08 | 公開日 | 2014-01-22 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Structural analysis of human 2'-O-ribose methyltransferases involved in mRNA cap structure formation. Nat Commun, 5, 2014
|
|
7R08
| Abortive infection DNA polymerase Abi-P2 | 分子名称: | Reverse transcriptase | 著者 | Gapinska, M.A, Figiel, M, Czarnocki Cieciura, M, Nowotny, M, Zajko, W. | 登録日 | 2022-02-01 | 公開日 | 2022-09-07 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Mechanism of protein-primed template-independent DNA synthesis by Abi polymerases. Nucleic Acids Res., 50, 2022
|
|
7R07
| Abortive infection DNA polymerase AbiK from Lactococcus lactis | 分子名称: | AbiK, DNA (5'-D(*CP*CP*CP*CP*CP*CP*CP*CP*CP*CP*C)-3'), MAGNESIUM ION | 著者 | Figiel, M, Gapinska, M, Czarnocki-Cieciura, M, Zajko, W, Nowotny, M. | 登録日 | 2022-02-01 | 公開日 | 2022-09-07 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Mechanism of protein-primed template-independent DNA synthesis by Abi polymerases. Nucleic Acids Res., 50, 2022
|
|
7R06
| Abortive infection DNA polymerase AbiK from Lactococcus lactis | 分子名称: | AbiK, DNA (5'-D(*CP*CP*CP*CP*CP*CP*CP*CP*CP*CP*CP*C)-3') | 著者 | Figiel, M, Nowotny, M, Gapinska, M, Czarnocki-Cieciura, M, Zajko, W. | 登録日 | 2022-02-01 | 公開日 | 2022-09-07 | 最終更新日 | 2022-10-05 | 実験手法 | ELECTRON MICROSCOPY (2.27 Å) | 主引用文献 | Mechanism of protein-primed template-independent DNA synthesis by Abi polymerases. Nucleic Acids Res., 50, 2022
|
|
7PIK
| Cryo-EM structure of E. coli TnsB in complex with right end fragment of Tn7 transposon | 分子名称: | Right end fragment of Tn7 transposon, Transposon Tn7 transposition protein TnsB | 著者 | Kaczmarska, Z, Czarnocki-Cieciura, M, Rawski, M, Nowotny, M. | 登録日 | 2021-08-20 | 公開日 | 2022-06-15 | 最終更新日 | 2022-08-03 | 実験手法 | ELECTRON MICROSCOPY (2.68 Å) | 主引用文献 | Structural basis of transposon end recognition explains central features of Tn7 transposition systems. Mol.Cell, 82, 2022
|
|
5J5Y
| Translation initiation factor 4E in complex with m2(7,2'O)GppCCl2ppG mRNA 5' cap analog | 分子名称: | 2-amino-9-{5-O-[(R)-{[(S)-{dichloro[(R)-hydroxy(phosphonooxy)phosphoryl]methyl}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]-2-O-methyl-beta-D-ribofuranosyl}-7-methyl-9H-purin-7-ium-6-olate, Eukaryotic translation initiation factor 4E, GLYCEROL | 著者 | Warminski, M, Nowak, E, Rydzik, A.M, Kowalska, J, Jemielity, J, Nowotny, M. | 登録日 | 2016-04-04 | 公開日 | 2017-05-10 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | mRNA cap analogues substituted in the tetraphosphate chain with CX2: identification of O-to-CCl2 as the first bridging modification that confers resistance to decapping without impairing translation. Nucleic Acids Res., 45, 2017
|
|
6S16
| T. thermophilus RuvC in complex with Holliday junction substrate | 分子名称: | CHLORIDE ION, Crossover junction endodeoxyribonuclease RuvC, DNA (33-MER), ... | 著者 | Gorecka, K.M, Krepl, M, Szlachcic, A, Poznanski, J, Sponer, J, Nowotny, M. | 登録日 | 2019-06-18 | 公開日 | 2019-09-25 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (3.409 Å) | 主引用文献 | RuvC uses dynamic probing of the Holliday junction to achieve sequence specificity and efficient resolution. Nat Commun, 10, 2019
|
|