8TXV
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![BU of 8txv by Molmil](/molmil-images/mine/8txv) | Cryo-EM structure of the human nucleosome core particle ubiquitylated at histone H2A K15 in complex with RNF168 (Class 1) | 分子名称: | DNA (147-MER), E3 ubiquitin-protein ligase RNF168, Histone H2A type 1-B/E, ... | 著者 | Hu, Q, Botuyan, M.V, Zhao, D, Cui, G, Mer, G. | 登録日 | 2023-08-24 | 公開日 | 2024-01-17 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024
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8TXX
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![BU of 8txx by Molmil](/molmil-images/mine/8txx) | Cryo-EM structure of the human nucleosome core particle ubiquitylated at histone H2A K15 in complex with RNF168 (Class 3) | 分子名称: | DNA (147-MER), E3 ubiquitin-protein ligase RNF168, Histone H2A type 1-B/E, ... | 著者 | Hu, Q, Botuyan, M.V, Zhao, D, Cui, G, Mer, G. | 登録日 | 2023-08-24 | 公開日 | 2024-01-17 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024
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8UQB
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![BU of 8uqb by Molmil](/molmil-images/mine/8uqb) | Crystal structure of RNF168 (RING)-UbcH5c fused to H2A-H2B via a 20-residue linker (crystallization condition 1) | 分子名称: | CHLORIDE ION, E3 ubiquitin-protein ligase RNF168,Ubiquitin-conjugating enzyme E2 D3,Histone H2B type 2-E,Histone H2A type 1-B/E, ZINC ION | 著者 | Hu, Q, Botuyan, M.V, Mer, G. | 登録日 | 2023-10-23 | 公開日 | 2024-01-17 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.484 Å) | 主引用文献 | Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024
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8UPF
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![BU of 8upf by Molmil](/molmil-images/mine/8upf) | Cryo-EM structure of the human nucleosome core particle in complex with RNF168-UbcH5c | 分子名称: | DNA (147-MER), E3 ubiquitin-protein ligase RNF168, Histone H2A type 1-B/E, ... | 著者 | Hu, Q, Botuyan, M.V, Zhao, D, Cui, G, Mer, G. | 登録日 | 2023-10-22 | 公開日 | 2024-01-17 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024
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8UQA
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![BU of 8uqa by Molmil](/molmil-images/mine/8uqa) | Crystal structure of RNF168 (RING)-UbcH5c fused to H2A-H2B via a 12-residue linker | 分子名称: | CHLORIDE ION, E3 ubiquitin-protein ligase RNF168,Ubiquitin-conjugating enzyme E2 D3,Histone H2B type 2-E,Histone H2A type 1-B/E, SODIUM ION, ... | 著者 | Hu, Q, Botuyan, M.V, Mer, G. | 登録日 | 2023-10-23 | 公開日 | 2024-01-17 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.049 Å) | 主引用文献 | Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024
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8UQ9
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![BU of 8uq9 by Molmil](/molmil-images/mine/8uq9) | Crystal structure of RNF168 (RING)-UbcH5c fused to H2A-H2B via a 4-residue linker | 分子名称: | CHLORIDE ION, E3 ubiquitin-protein ligase RNF168,Ubiquitin-conjugating enzyme E2 D3,Histone H2B type 2-E,Histone H2A type 1-B/E, GLYCEROL, ... | 著者 | Hu, Q, Botuyan, M.V, Mer, G. | 登録日 | 2023-10-23 | 公開日 | 2024-01-17 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024
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8U13
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![BU of 8u13 by Molmil](/molmil-images/mine/8u13) | Cryo-EM structure of the human nucleosome core particle ubiquitylated at histone H2A lysine 15 in complex with RNF168-UbcH5c (class 1) | 分子名称: | DNA (146-MER), DNA (147-MER), E3 ubiquitin-protein ligase RNF168, ... | 著者 | Hu, Q, Botuyan, M.V, Zhao, D, Cui, G, Mer, G. | 登録日 | 2023-08-30 | 公開日 | 2024-01-17 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024
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8UQ8
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![BU of 8uq8 by Molmil](/molmil-images/mine/8uq8) | Crystal structure of RNF168 (RING)-UbcH5c fused to H2A-H2B via a 2-residue linker | 分子名称: | CHLORIDE ION, E3 ubiquitin-protein ligase RNF168,Ubiquitin-conjugating enzyme E2 D3,Histone H2B type 2-E,Histone H2A type 1-B/E, GLYCEROL, ... | 著者 | Hu, Q, Botuyan, M.V, Mer, G. | 登録日 | 2023-10-23 | 公開日 | 2024-01-17 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.34 Å) | 主引用文献 | Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024
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8UQD
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![BU of 8uqd by Molmil](/molmil-images/mine/8uqd) | Crystal structure of RNF168 (RING)-UbcH5c fused to H2A-H2B via a 20-residue linker (condition 2. RING not modeled in density) | 分子名称: | E3 ubiquitin-protein ligase RNF168,Ubiquitin-conjugating enzyme E2 D3,Histone H2B type 2-E,Histone H2A type 1-B/E | 著者 | Hu, Q, Botuyan, M.V, Mer, G. | 登録日 | 2023-10-23 | 公開日 | 2024-01-17 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (3.893 Å) | 主引用文献 | Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024
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8TXW
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![BU of 8txw by Molmil](/molmil-images/mine/8txw) | Cryo-EM structure of the human nucleosome core particle ubiquitylated at histone H2A K15 in complex with RNF168 (Class 2) | 分子名称: | DNA (147-MER), E3 ubiquitin-protein ligase RNF168, Histone H2A type 1-B/E, ... | 著者 | Hu, Q, Botuyan, M.V, Zhao, D, Cui, G, Mer, G. | 登録日 | 2023-08-24 | 公開日 | 2024-01-17 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024
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8UQC
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![BU of 8uqc by Molmil](/molmil-images/mine/8uqc) | Crystal structure of RNF168 (RING)-UbcH5c fused to H2A-H2B via a 20-residue linker (crystallization condition 2) | 分子名称: | E3 ubiquitin-protein ligase RNF168,Ubiquitin-conjugating enzyme E2 D3,Histone H2B type 2-E,Histone H2A type 1-B/E, ZINC ION | 著者 | Hu, Q, Botuyan, M.V, Mer, G. | 登録日 | 2023-10-23 | 公開日 | 2024-01-17 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.61 Å) | 主引用文献 | Mechanisms of RNF168 nucleosome recognition and ubiquitylation. Mol.Cell, 84, 2024
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7LV8
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![BU of 7lv8 by Molmil](/molmil-images/mine/7lv8) | Structure of the Marseillevirus nucleosome | 分子名称: | DNA (123-MER), Histone doublet Beta-Alpha (Alpha), Histone doublet Beta-Alpha (Beta), ... | 著者 | Valencia-Sanchez, M.I, Abini-Agbomson, S, Armache, K.-J. | 登録日 | 2021-02-24 | 公開日 | 2021-05-05 | 最終更新日 | 2021-05-26 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | The structure of a virus-encoded nucleosome. Nat.Struct.Mol.Biol., 28, 2021
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7LV9
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![BU of 7lv9 by Molmil](/molmil-images/mine/7lv9) | Marseillevirus heterotrimeric (hexameric) nucleosome | 分子名称: | DNA (96-MER), Histone doublet Beta-Alpha (Alpha), Histone doublet Beta-Alpha (Beta), ... | 著者 | Valencia-Sanchez, M.I, Abini-Agbomson, S, Armache, K.-J. | 登録日 | 2021-02-24 | 公開日 | 2021-05-05 | 最終更新日 | 2021-05-26 | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | 主引用文献 | The structure of a virus-encoded nucleosome. Nat.Struct.Mol.Biol., 28, 2021
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6L0X
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![BU of 6l0x by Molmil](/molmil-images/mine/6l0x) | The First Tudor Domain of PHF20L1 | 分子名称: | CITRIC ACID, GLYCEROL, PHD finger protein 20-like protein 1 | 著者 | Lv, M.Q, Gao, J. | 登録日 | 2019-09-27 | 公開日 | 2020-09-23 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Conformational Selection in Ligand Recognition by the First Tudor Domain of PHF20L1. J Phys Chem Lett, 11, 2020
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3C43
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![BU of 3c43 by Molmil](/molmil-images/mine/3c43) | Human dipeptidyl peptidase IV/CD26 in complex with a flouroolefin inhibitor | 分子名称: | (2S,3S)-4-cyclopropyl-3-{(3R,5R)-3-[2-fluoro-4-(methylsulfonyl)phenyl]-1,2,4-oxadiazolidin-5-yl}-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Scapin, G, Edmondson, S.D, Weber, A.E. | 登録日 | 2008-01-29 | 公開日 | 2008-04-22 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Fluoroolefins as amide bond mimics in dipeptidyl peptidase IV inhibitors Bioorg.Med.Chem.Lett., 18, 2008
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6JKM
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![BU of 6jkm by Molmil](/molmil-images/mine/6jkm) | Crystal structure of BubR1 kinase domain | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... | 著者 | Lin, L, Ye, S, Huang, Y, Liu, X, Zhang, R, Yao, X. | 登録日 | 2019-03-01 | 公開日 | 2019-06-26 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | BubR1 phosphorylates CENP-E as a switch enabling the transition from lateral association to end-on capture of spindle microtubules. Cell Res., 29, 2019
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3C1C
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![BU of 3c1c by Molmil](/molmil-images/mine/3c1c) | The effect of H3 K79 dimethylation and H4 K20 trimethylation on nucleosome and chromatin structure | 分子名称: | Histone 2, H2bf, Histone H2A type 1, ... | 著者 | Lu, X, Simon, M, Chodaparambil, J, Hansen, J, Shokat, K, Luger, K. | 登録日 | 2008-01-22 | 公開日 | 2008-10-07 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | 主引用文献 | The effect of H3K79 dimethylation and H4K20 trimethylation on nucleosome and chromatin structure. Nat.Struct.Mol.Biol., 15, 2008
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6L1P
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![BU of 6l1p by Molmil](/molmil-images/mine/6l1p) | Crystal structure of PHF20L1 in complex with Hit 1 | 分子名称: | 4-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)phenol, GLYCEROL, PHD finger protein 20-like protein 1, ... | 著者 | Lv, M.Q, Gao, J. | 登録日 | 2019-09-29 | 公開日 | 2020-09-23 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.231 Å) | 主引用文献 | Conformational Selection in Ligand Recognition by the First Tudor Domain of PHF20L1. J Phys Chem Lett, 11, 2020
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7X7T
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![BU of 7x7t by Molmil](/molmil-images/mine/7x7t) | Cryo-EM structure of SARS-CoV-2 spike protein in complex with three nAbs X01, X10 and X17 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, X01 heavy chain, ... | 著者 | Sun, H, Liu, L, Zheng, Q, Li, S, Zhang, T, Xia, N. | 登録日 | 2022-03-10 | 公開日 | 2022-08-17 | 最終更新日 | 2022-11-23 | 実験手法 | ELECTRON MICROSCOPY (3.48 Å) | 主引用文献 | The neutralizing breadth of antibodies targeting diverse conserved epitopes between SARS-CoV and SARS-CoV-2. Proc.Natl.Acad.Sci.USA, 119, 2022
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7X7U
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![BU of 7x7u by Molmil](/molmil-images/mine/7x7u) | Cryo-EM structure of SARS-CoV-2 Delta variant spike protein in complex with three nAbs X01, X10 and X17 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, X01 heavy chain, ... | 著者 | Sun, H, Liu, L, Zhang, T, Zheng, Q, Li, S, Xia, N. | 登録日 | 2022-03-10 | 公開日 | 2022-08-17 | 最終更新日 | 2022-11-23 | 実験手法 | ELECTRON MICROSCOPY (3.77 Å) | 主引用文献 | The neutralizing breadth of antibodies targeting diverse conserved epitopes between SARS-CoV and SARS-CoV-2. Proc.Natl.Acad.Sci.USA, 119, 2022
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6L1C
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![BU of 6l1c by Molmil](/molmil-images/mine/6l1c) | |
2QJ6
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![BU of 2qj6 by Molmil](/molmil-images/mine/2qj6) | Crystal structure analysis of a 14 repeat C-terminal fragment of toxin TcdA in Clostridium difficile | 分子名称: | Toxin A | 著者 | Albesa-Jove, D, Bertrand, T, Carpenter, L, Lim, J, Brown, K.A, Fairweather, N. | 登録日 | 2007-07-06 | 公開日 | 2008-07-15 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Solution and crystal structures of the cell binding domain of toxins TcdA and TcdB from Clostridium difficile To be Published
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6L1I
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![BU of 6l1i by Molmil](/molmil-images/mine/6l1i) | |
2JTK
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![BU of 2jtk by Molmil](/molmil-images/mine/2jtk) | |
4HZ0
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![BU of 4hz0 by Molmil](/molmil-images/mine/4hz0) | Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity. | 分子名称: | 7-(1H-imidazol-1-yl)-2-(pyridin-3-yl)[1,3]thiazolo[5,4-d]pyrimidin-5-amine, DNA topoisomerase 4 subunit B, MAGNESIUM ION | 著者 | Bensen, D.C, Trzoss, M, Tari, L.W. | 登録日 | 2012-11-14 | 公開日 | 2013-02-13 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity. Bioorg.Med.Chem.Lett., 23, 2013
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