3C43

Human dipeptidyl peptidase IV/CD26 in complex with a flouroolefin inhibitor

Summary for 3C43

Entry DOI	10.2210/pdb3c43/pdb
Related	1x70 2fjp 2hha 2iit 2iiv 2oph 3C45
Descriptor	Dipeptidyl peptidase 4 soluble form, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
Functional Keywords	alpha/beta, beta-propeller, dimer, aminopeptidase, glycoprotein, hydrolase, membrane, protease, secreted, serine protease, signal-anchor, transmembrane
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	175017.20
Authors	Scapin, G.,Edmondson, S.D.,Weber, A.E. (deposition date: 2008-01-29, release date: 2008-04-22, Last modification date: 2023-08-30)
Primary citation	Edmondson, S.D.,Wei, L.,Xu, J.,Shang, J.,Xu, S.,Pang, J.,Chaudhary, A.,Dean, D.C.,He, H.,Leiting, B.,Lyons, K.A.,Patel, R.A.,Patel, S.B.,Scapin, G.,Wu, J.K.,Beconi, M.G.,Thornberry, N.A.,Weber, A.E. Fluoroolefins as amide bond mimics in dipeptidyl peptidase IV inhibitors Bioorg.Med.Chem.Lett., 18:2409-2413, 2008 Cited by PubMed: 18331795 DOI: 10.1016/j.bmcl.2008.02.050 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation