5WLE
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5WLF
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1GUJ
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![BU of 1guj by Molmil](/molmil-images/mine/1guj) | Insulin at pH 2: structural analysis of the conditions promoting insulin fibre formation. | 分子名称: | INSULIN, SULFATE ION | 著者 | Whittingham, J.L, Scott, D.J, Chance, K, Wilson, A, Finch, J, Brange, J, Dodson, G.G. | 登録日 | 2002-01-28 | 公開日 | 2002-03-08 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | 主引用文献 | Insulin at Ph2: Structural Analysis of the Conditions Promoting Insulin Fibre Formation J.Mol.Biol., 318, 2002
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6H8P
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![BU of 6h8p by Molmil](/molmil-images/mine/6h8p) | JMJD2A/ KDM4A COMPLEXED WITH NI(II), NOG AND Histone H1.4(18-32)K26me3 peptide (15-mer) | 分子名称: | CHLORIDE ION, GLYCEROL, Histone H1.4, ... | 著者 | Chowdhury, R, Walport, L.J, Schofield, C.J. | 登録日 | 2018-08-03 | 公開日 | 2018-08-15 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.983 Å) | 主引用文献 | Mechanistic and structural studies of KDM-catalysed demethylation of histone 1 isotype 4 at lysine 26. FEBS Lett., 592, 2018
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6HU9
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![BU of 6hu9 by Molmil](/molmil-images/mine/6hu9) | III2-IV2 mitochondrial respiratory supercomplex from S. cerevisiae | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE, 5-(3,7,11,15,19,23-HEXAMETHYL-TETRACOSA-2,6,10,14,18,22-HEXAENYL)-2,3-DIMETHOXY-6-METHYL-BENZENE-1,4-DIOL, CALCIUM ION, ... | 著者 | Hartley, A.M, Pinotsis, N, Marechal, A. | 登録日 | 2018-10-05 | 公開日 | 2018-12-26 | 最終更新日 | 2019-12-11 | 実験手法 | ELECTRON MICROSCOPY (3.35 Å) | 主引用文献 | Structure of yeast cytochrome c oxidase in a supercomplex with cytochrome bc1. Nat. Struct. Mol. Biol., 26, 2019
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8J02
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![BU of 8j02 by Molmil](/molmil-images/mine/8j02) | Human KCNQ2(F104A)-CaM-PIP2-CBD complex in state II | 分子名称: | Calmodulin-1, Potassium voltage-gated channel subfamily KQT member 2, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate, ... | 著者 | Ma, D, Li, X, Guo, J. | 登録日 | 2023-04-09 | 公開日 | 2023-12-13 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Ligand activation mechanisms of human KCNQ2 channel. Nat Commun, 14, 2023
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8J01
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![BU of 8j01 by Molmil](/molmil-images/mine/8j01) | Human KCNQ2-CaM in complex with CBD and PIP2 | 分子名称: | Calmodulin-1, Potassium voltage-gated channel subfamily KQT member 2, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate, ... | 著者 | Ma, D, Li, X, Guo, J. | 登録日 | 2023-04-09 | 公開日 | 2023-12-13 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Ligand activation mechanisms of human KCNQ2 channel. Nat Commun, 14, 2023
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1GN4
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![BU of 1gn4 by Molmil](/molmil-images/mine/1gn4) | H145E mutant of Mycobacterium tuberculosis iron-superoxide dismutase. | 分子名称: | MANGANESE (II) ION, SUPEROXIDE DISMUTASE | 著者 | Bunting, K.A, Cooper, J.B, Badasso, M.O, Tickle, I.J, Newton, M, Wood, S.P, Zhang, Y, Young, D.B. | 登録日 | 2001-10-02 | 公開日 | 2001-10-05 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Engineering a Change in the Metal-Ion Specificity of the Iron-Depedent Superoxide Dismutase from Mycobacterium Tuberculosis. X-Ray Structure Analysis of Site-Directed Mutants Eur.J.Biochem., 251, 1998
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1GN2
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![BU of 1gn2 by Molmil](/molmil-images/mine/1gn2) | S123C mutant of the iron-superoxide dismutase from Mycobacterium tuberculosis. | 分子名称: | FE (III) ION, SUPEROXIDE DISMUTASE | 著者 | Bunting, K.A, Cooper, J.B, Tickle, I.J, Young, D.B. | 登録日 | 2001-10-02 | 公開日 | 2001-10-05 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | Engineering of an Intersubunit Disulfide Bridge in the Iron-Superoxide Dismutase of Mycobacterium Tuberculosis. Arch.Biochem.Biophys., 397, 2002
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1GN3
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![BU of 1gn3 by Molmil](/molmil-images/mine/1gn3) | H145Q mutant of Mycobacterium tuberculosis iron-superoxide dismutase. | 分子名称: | FE (III) ION, SUPEROXIDE DISMUTASE | 著者 | Bunting, K.A, Cooper, J.B, Badasso, M.O, Tickle, I.J, Newton, M, Wood, S.P, Zhang, Y, Young, D.B. | 登録日 | 2001-10-02 | 公開日 | 2001-10-05 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (4 Å) | 主引用文献 | Engineering a Change in the Metal-Ion Specificity of the Iron-Depedent Superoxide Dismutase from Mycobacterium Tuberculosis. X-Ray Structure Analysis of Site-Directed Mutants. Eur.J.Biochem., 251, 1998
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6GWR
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![BU of 6gwr by Molmil](/molmil-images/mine/6gwr) | Structure of the kinase domain of human DDR1 in complex with a potent and selective inhibitor of DDR1 and DDR2 | 分子名称: | 1,2-ETHANEDIOL, 3-(2-imidazo[1,2-a]pyrazin-3-ylethynyl)-~{N}-[3-[(4-methylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl]-4-propan-2-yl-benzamide, Epithelial discoidin domain-containing receptor 1, ... | 著者 | Pinkas, D.M, Fox, A.E, Kupinska, K, Burgess-Brown, N.A, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A.N. | 登録日 | 2018-06-25 | 公開日 | 2018-08-08 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | 主引用文献 | Design, Synthesis, and Biological Evaluation of 3-(Imidazo[1,2- a]pyrazin-3-ylethynyl)-4-isopropyl- N-(3-((4-methylpiperazin-1-yl)methyl)-5-(trifluoromethyl)phenyl)benzamide as a Dual Inhibitor of Discoidin Domain Receptors 1 and 2. J. Med. Chem., 61, 2018
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6M6A
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![BU of 6m6a by Molmil](/molmil-images/mine/6m6a) | Cryo-EM structure of Thermus thermophilus Mfd in complex with RNA polymerase | 分子名称: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | 著者 | Shi, J, Wen, A, Feng, Y. | 登録日 | 2020-03-14 | 公開日 | 2020-10-14 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (5 Å) | 主引用文献 | Structural basis of Mfd-dependent transcription termination. Nucleic Acids Res., 48, 2020
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6FWL
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![BU of 6fwl by Molmil](/molmil-images/mine/6fwl) | Structure of an E333Q variant of the GH99 endo-alpha-mannanase from Bacteroides xylanisolvens in complex alpha-Glc-1,3-(1,2-anhydro-carba-mannose) | 分子名称: | (1~{S},2~{S},3~{R},4~{R},6~{R})-4-(hydroxymethyl)-7-oxabicyclo[4.1.0]heptane-2,3-diol, ACETATE ION, Glycosyl hydrolase family 71, ... | 著者 | Sobala, L.F, Speciale, G, Hakki, Z, Fernandes, P.Z, Raich, L, Rojas-Cervellera, V, Bennet, A, Thompson, A.J, Bernardo-Seisdedos, G, Millet, O, Zhu, S, Lu, D, Sollogoub, M, Rovira, C, Jimenez-Barbero, J, Davies, G.J, Williams, S.J. | 登録日 | 2018-03-06 | 公開日 | 2019-09-18 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.12 Å) | 主引用文献 | An Epoxide Intermediate in Glycosidase Catalysis. Acs Cent.Sci., 6, 2020
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6FWP
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![BU of 6fwp by Molmil](/molmil-images/mine/6fwp) | Structure of the GH99 endo-alpha-mannanase from Bacteroides xylanisolvens in complex with alpha-1,3-mannobiose and alpha-1,2-mannobiose | 分子名称: | ACETATE ION, Glycosyl hydrolase family 71, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose, ... | 著者 | Sobala, L.F, Speciale, G, Hakki, Z, Fernandes, P.Z, Raich, L, Rojas-Cervellera, V, Bennet, A, Thompson, A.J, Bernardo-Seisdedos, G, Millet, O, Zhu, S, Lu, D, Sollogoub, M, Rovira, C, Jimenez-Barbero, J, Davies, G.J, Williams, S.J. | 登録日 | 2018-03-06 | 公開日 | 2019-09-18 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.08 Å) | 主引用文献 | An Epoxide Intermediate in Glycosidase Catalysis. Acs Cent.Sci., 6, 2020
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6G4Z
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![BU of 6g4z by Molmil](/molmil-images/mine/6g4z) | Crystal structure of murine NF-kappaB inducing kinase (NIK) in complex with compound 2f | 分子名称: | 5-fluoranyl-1-[4-[2-[(3~{R})-1-methyl-3-oxidanyl-2-oxidanylidene-pyrrol-3-yl]ethynyl]pyridin-2-yl]indazole-3-carboxamide, Mitogen-activated protein kinase kinase kinase 14 | 著者 | Leonardo-Silvestre, H, McEwan, P.A, Hymowitz, S.G. | 登録日 | 2018-03-28 | 公開日 | 2018-07-04 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.84 Å) | 主引用文献 | Scaffold-Hopping Approach To Discover Potent, Selective, and Efficacious Inhibitors of NF-kappa B Inducing Kinase. J. Med. Chem., 61, 2018
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6FWG
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![BU of 6fwg by Molmil](/molmil-images/mine/6fwg) | Structure of an E333Q variant of the GH99 endo-alpha-mannanase from Bacteroides xylanisolvens in complex with tetramannoside yeast mannan fragment | 分子名称: | ACETATE ION, Glycosyl hydrolase family 71, alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-methyl alpha-D-mannopyranoside | 著者 | Sobala, L.F, Speciale, G, Hakki, Z, Fernandes, P.Z, Raich, L, Rojas-Cervellera, V, Bennet, A, Thompson, A.J, Bernardo-Seisdedos, G, Millet, O, Zhu, S, Lu, D, Sollogoub, M, Rovira, C, Jimenez-Barbero, J, Davies, G.J, Williams, S.J. | 登録日 | 2018-03-06 | 公開日 | 2019-09-18 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.07 Å) | 主引用文献 | An Epoxide Intermediate in Glycosidase Catalysis. Acs Cent.Sci., 6, 2020
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6FWM
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![BU of 6fwm by Molmil](/molmil-images/mine/6fwm) | Structure of the GH99 endo-alpha-mannanase from Bacteroides xylanisolvens in complex with alpha-Glc-1,3-1,2-anhydro-mannose hydrolyzed by enzyme | 分子名称: | (1~{S},2~{R},3~{S},4~{R},5~{R})-5-(hydroxymethyl)cyclohexane-1,2,3,4-tetrol, ACETATE ION, Glycosyl hydrolase family 71, ... | 著者 | Sobala, L.F, Speciale, G, Hakki, Z, Fernandes, P.Z, Raich, L, Rojas-Cervellera, V, Bennet, A, Thompson, A.J, Bernardo-Seisdedos, G, Millet, O, Zhu, S, Lu, D, Sollogoub, M, Rovira, C, Jimenez-Barbero, J, Davies, G.J, Williams, S.J. | 登録日 | 2018-03-06 | 公開日 | 2019-09-18 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.28 Å) | 主引用文献 | An Epoxide Intermediate in Glycosidase Catalysis. Acs Cent.Sci., 6, 2020
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6FWQ
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![BU of 6fwq by Molmil](/molmil-images/mine/6fwq) | Structure of an E333Q variant of the GH99 endo-alpha-mannanase from Bacteroides xylanisolvens in complex with alpha-1,3-mannobiose and alpha-1,2-mannobiose | 分子名称: | Glycosyl hydrolase family 71, SODIUM ION, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose, ... | 著者 | Sobala, L.F, Speciale, G, Hakki, Z, Fernandes, P.Z, Raich, L, Rojas-Cervellera, V, Bennet, A, Thompson, A.J, Bernardo-Seisdedos, G, Millet, O, Zhu, S, Lu, D, Sollogoub, M, Rovira, C, Jimenez-Barbero, J, Davies, G.J, Williams, S.J. | 登録日 | 2018-03-07 | 公開日 | 2019-09-18 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | An Epoxide Intermediate in Glycosidase Catalysis. Acs Cent.Sci., 6, 2020
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3FMZ
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5USJ
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![BU of 5usj by Molmil](/molmil-images/mine/5usj) | Crystal Structure of human KRAS G12D mutant in complex with GDPNP | 分子名称: | GTPase KRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | 著者 | Huang, C.S, Kaplan, A, Stockwell, B.R, Tong, L. | 登録日 | 2017-02-13 | 公開日 | 2017-03-22 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | Multivalent Small-Molecule Pan-RAS Inhibitors. Cell, 168, 2017
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6M6B
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![BU of 6m6b by Molmil](/molmil-images/mine/6m6b) | Cryo-EM structure of Thermus thermophilus Mfd in complex with RNA polymerase and ATP-gamma-S | 分子名称: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | 著者 | Shi, J, Wen, A, Feng, Y. | 登録日 | 2020-03-14 | 公開日 | 2020-10-14 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Structural basis of Mfd-dependent transcription termination. Nucleic Acids Res., 48, 2020
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5Y36
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![BU of 5y36 by Molmil](/molmil-images/mine/5y36) | Cryo-EM structure of SpCas9-sgRNA-DNA ternary complex | 分子名称: | CRISPR-associated endonuclease Cas9/Csn1, MAGNESIUM ION, complementary DNA strand, ... | 著者 | Huang, Q, Li, G, Huai, C. | 登録日 | 2017-07-27 | 公開日 | 2017-12-06 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (5.2 Å) | 主引用文献 | Structural insights into DNA cleavage activation of CRISPR-Cas9 system Nat Commun, 8, 2017
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5Y87
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6FWI
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![BU of 6fwi by Molmil](/molmil-images/mine/6fwi) | Structure of the GH99 endo-alpha-mannanase from Bacteroides xylanisolvens in complex with alpha-Glc-1,3-(1,2-anhydro-carba-mannosamine) | 分子名称: | (1~{R},2~{R},3~{R},4~{R},6~{R})-4-(hydroxymethyl)-7-azabicyclo[4.1.0]heptane-2,3-diol, ACETATE ION, Glycosyl hydrolase family 71, ... | 著者 | Sobala, L.F, Speciale, G, Hakki, Z, Fernandes, P.Z, Raich, L, Rojas-Cervellera, V, Bennet, A, Thompson, A.J, Bernardo-Seisdedos, G, Millet, O, Zhu, S, Lu, D, Sollogoub, M, Rovira, C, Jimenez-Barbero, J, Davies, G.J, Williams, S.J. | 登録日 | 2018-03-06 | 公開日 | 2019-09-18 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | 主引用文献 | An Epoxide Intermediate in Glycosidase Catalysis. Acs Cent.Sci., 6, 2020
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1G4P
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![BU of 1g4p by Molmil](/molmil-images/mine/1g4p) | THIAMIN PHOSPHATE SYNTHASE | 分子名称: | 4-AMINO-2-TRIFLUOROMETHYL-5-HYDROXYMETHYLPYRIMIDINE PYROPHOSPHATE, MAGNESIUM ION, THIAMIN PHOSPHATE SYNTHASE | 著者 | Peapus, D.H, Chiu, H.-J, Campobasso, N, Reddick, J.J, Begley, T.P, Ealick, S.E. | 登録日 | 2000-10-27 | 公開日 | 2001-09-26 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural characterization of the enzyme-substrate, enzyme-intermediate, and enzyme-product complexes of thiamin phosphate synthase. Biochemistry, 40, 2001
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