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6H8P

JMJD2A/ KDM4A COMPLEXED WITH NI(II), NOG AND Histone H1.4(18-32)K26me3 peptide (15-mer)

Summary for 6H8P
Entry DOI10.2210/pdb6h8p/pdb
DescriptorLysine-specific demethylase 4A, Histone H1.4, NICKEL (II) ION, ... (8 entities in total)
Functional Keywordsjmjd2a, kdm4a, oxidoreductase, non-heme, iron, 2-oxoglutarate, dioxygenase, oxygenase, double-stranded beta helix, dsbh, facial triad, demethylase, histone, jmjc domain, metal binding protein, epigenetic and transcription regulation, chromatin regulator, hydroxylation
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains4
Total formula weight92812.16
Authors
Chowdhury, R.,Walport, L.J.,Schofield, C.J. (deposition date: 2018-08-03, release date: 2018-08-15, Last modification date: 2024-01-17)
Primary citationWalport, L.J.,Hopkinson, R.J.,Chowdhury, R.,Zhang, Y.,Bonnici, J.,Schiller, R.,Kawamura, A.,Schofield, C.J.
Mechanistic and structural studies of KDM-catalysed demethylation of histone 1 isotype 4 at lysine 26.
FEBS Lett., 592:3264-3273, 2018
Cited by
PubMed: 30156264
DOI: 10.1002/1873-3468.13231
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.983 Å)
Structure validation

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