7N24
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![BU of 7n24 by Molmil](/molmil-images/mine/7n24) | NMR structure of native EpI | 分子名称: | Alpha-conotoxin EpI | 著者 | Conibear, A.C, Rosengren, K.J, Lee, H.S. | 登録日 | 2021-05-28 | 公開日 | 2021-11-17 | 最終更新日 | 2023-11-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Posttranslational modifications of alpha-conotoxins: sulfotyrosine and C-terminal amidation stabilise structures and increase acetylcholine receptor binding. Rsc Med Chem, 12, 2021
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7N25
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![BU of 7n25 by Molmil](/molmil-images/mine/7n25) | NMR structure of EpI-OH | 分子名称: | Alpha-conotoxin EpI-OH | 著者 | Conibear, A.C, Rosengren, K.J, Lee, H.S. | 登録日 | 2021-05-28 | 公開日 | 2021-11-17 | 最終更新日 | 2023-11-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Posttranslational modifications of alpha-conotoxins: sulfotyrosine and C-terminal amidation stabilise structures and increase acetylcholine receptor binding. Rsc Med Chem, 12, 2021
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7N26
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6IUV
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![BU of 6iuv by Molmil](/molmil-images/mine/6iuv) | Crystal structure of influenza A virus H5 hemagglutinin globular head in complex with the Fab of antibody 3C11 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 3C11 Heavy Chain, 3C11 Light Chain, ... | 著者 | Wang, P, Zuo, Y, Sun, J, Zhang, L, Wang, X. | 登録日 | 2018-11-30 | 公開日 | 2019-01-16 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.332 Å) | 主引用文献 | Structural and functional definition of a vulnerable site on the hemagglutinin of highly pathogenic avian influenza A virus H5N1. J. Biol. Chem., 294, 2019
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4MJ5
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![BU of 4mj5 by Molmil](/molmil-images/mine/4mj5) | Crystal Structure of HLA-A*1101 in complex with H1-22, an influenza A(H1N1) virus epitope | 分子名称: | Beta-2-microglobulin, HLA class I histocompatibility antigen, A-11 alpha chain, ... | 著者 | Liu, J, Tan, S, Zhao, M, Qi, J, Gao, G.F. | 登録日 | 2013-09-03 | 公開日 | 2014-10-08 | 最終更新日 | 2022-08-24 | 実験手法 | X-RAY DIFFRACTION (2.401 Å) | 主引用文献 | Cross-immunity Against Avian Influenza A(H7N9) Virus in the Healthy Population Is Affected by Antigenicity-Dependent Substitutions. J.Infect.Dis., 214, 2016
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4MJ6
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![BU of 4mj6 by Molmil](/molmil-images/mine/4mj6) | Crystal Structure of HLA-A*1101 in complex with H7-22, an influenza A(H7N9) virus epitope | 分子名称: | Beta-2-microglobulin, HLA class I histocompatibility antigen, A-11 alpha chain, ... | 著者 | Liu, J, Tan, S, Zhao, M, Qi, J, Gao, G.F. | 登録日 | 2013-09-03 | 公開日 | 2014-10-08 | 最終更新日 | 2022-08-24 | 実験手法 | X-RAY DIFFRACTION (2.57 Å) | 主引用文献 | Cross-immunity Against Avian Influenza A(H7N9) Virus in the Healthy Population Is Affected by Antigenicity-Dependent Substitutions. J.Infect.Dis., 214, 2016
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4YF9
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7N21
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![BU of 7n21 by Molmil](/molmil-images/mine/7n21) | NMR structure of AnIB-OH | 分子名称: | Alpha-conotoxin AnIB | 著者 | Conibear, A.C, Rosengren, K.J, Lee, H.S. | 登録日 | 2021-05-28 | 公開日 | 2021-11-17 | 最終更新日 | 2023-11-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Posttranslational modifications of alpha-conotoxins: sulfotyrosine and C-terminal amidation stabilise structures and increase acetylcholine receptor binding. Rsc Med Chem, 12, 2021
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7N23
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7N22
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7N0T
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7N20
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![BU of 7n20 by Molmil](/molmil-images/mine/7n20) | NMR structure of native AnIB | 分子名称: | Alpha-conotoxin AnIB | 著者 | Conibear, A.C, Rosengren, K.J, Lee, H.S. | 登録日 | 2021-05-28 | 公開日 | 2021-11-17 | 最終更新日 | 2023-11-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Posttranslational modifications of alpha-conotoxins: sulfotyrosine and C-terminal amidation stabilise structures and increase acetylcholine receptor binding. Rsc Med Chem, 12, 2021
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5CGD
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![BU of 5cgd by Molmil](/molmil-images/mine/5cgd) | Structure of the human class C GPCR metabotropic glutamate receptor 5 transmembrane domain in complex with the negative allosteric modulator 3-chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile - (HTL14242) | 分子名称: | 3-chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile, Metabotropic glutamate receptor 5,Endolysin,Metabotropic glutamate receptor 5, OLEIC ACID | 著者 | Christopher, J.A, Aves, S.J, Bennett, K.A, Dore, A.S, Errey, J.C, Jazayeri, A, Marshall, F.H, Okrasa, K, Serrano-Vega, M.J, Tehan, B.G, Wiggin, G.R, Congreve, M. | 登録日 | 2015-07-09 | 公開日 | 2015-08-12 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.603 Å) | 主引用文献 | Fragment and Structure-Based Drug Discovery for a Class C GPCR: Discovery of the mGlu5 Negative Allosteric Modulator HTL14242 (3-Chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile). J.Med.Chem., 58, 2015
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2K0T
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![BU of 2k0t by Molmil](/molmil-images/mine/2k0t) | High Resolution Solution NMR Structures of Oxaliplatin-DNA Adduct | 分子名称: | CYCLOHEXANE-1(R),2(R)-DIAMINE-PLATINUM(II), DNA (5'-D(*DCP*DCP*DTP*DCP*DTP*DGP*DGP*DTP*DCP*DTP*DCP*DC)-3'), DNA (5'-D(*DGP*DGP*DAP*DGP*DAP*DCP*DCP*DAP*DGP*DAP*DGP*DG)-3') | 著者 | Bhattacharyya, D, King, C.L, Chaney, S.G, Campbell, S.L. | 登録日 | 2008-02-14 | 公開日 | 2009-02-03 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Flanking Bases Influence the Nature of DNA Distortion by Platinum 1,2-Intrastrand (GG) Cross-Links. Plos One, 6, 2011
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5CGC
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![BU of 5cgc by Molmil](/molmil-images/mine/5cgc) | Structure of the human class C GPCR metabotropic glutamate receptor 5 transmembrane domain in complex with the negative allosteric modulator 3-chloro-4-fluoro-5-[6-(1H-pyrazol-1-yl)pyrimidin-4-yl]benzonitrile | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3-chloro-4-fluoro-5-[6-(1H-pyrazol-1-yl)pyrimidin-4-yl]benzonitrile, Metabotropic glutamate receptor 5,Endolysin,Metabotropic glutamate receptor 5, ... | 著者 | Christopher, J.A, Aves, S.J, Bennett, K.A, Dore, A.S, Errey, J.C, Jazayeri, A, Marshall, F.H, Okrasa, K, Serrano-Vega, M.J, Tehan, B.G, Wiggin, G.R, Congreve, M. | 登録日 | 2015-07-09 | 公開日 | 2015-08-12 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (3.101 Å) | 主引用文献 | Fragment and Structure-Based Drug Discovery for a Class C GPCR: Discovery of the mGlu5 Negative Allosteric Modulator HTL14242 (3-Chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile). J.Med.Chem., 58, 2015
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4YFA
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4YG1
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6LNT
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![BU of 6lnt by Molmil](/molmil-images/mine/6lnt) | Cryo-EM structure of immature Zika virus in complex with human antibody DV62.5 Fab | 分子名称: | Envelope protein, Fab DV62.5 heavy-chain variable region, Fab DV62.5 light-chain variable region, ... | 著者 | Tan, T.Y, Fibriansah, G, Kostyuchenko, V.A, Ng, T.S, Lim, X.X, Lim, X.N, Shi, J, Morais, M.C, Corti, D, Lok, S.M. | 登録日 | 2020-01-02 | 公開日 | 2020-02-26 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (8 Å) | 主引用文献 | Capsid protein structure in Zika virus reveals the flavivirus assembly process. Nat Commun, 11, 2020
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7NWK
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![BU of 7nwk by Molmil](/molmil-images/mine/7nwk) | Crystal structure of CDK9-Cyclin T1 bound by compound 6 | 分子名称: | Cyclin-T1, Cyclin-dependent kinase 9, N-((1R,3R)-3-(7-(4-fluoro-2-methoxyphenyl)-3H-imidazo[4,5-b]pyridin-2-yl)cyclopentyl)acetamide | 著者 | Collie, G.W, Ferguson, A.D. | 登録日 | 2021-03-16 | 公開日 | 2021-10-27 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.81 Å) | 主引用文献 | Discovery of a Series of 7-Azaindoles as Potent and Highly Selective CDK9 Inhibitors for Transient Target Engagement. J.Med.Chem., 64, 2021
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8UR9
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![BU of 8ur9 by Molmil](/molmil-images/mine/8ur9) | Crystal Structure of the SARS-CoV-2 Main Protease in Complex with Compound 61 | 分子名称: | (5P)-5-[(1P,3M,3'P)-3-{3-chloro-5-[(2-chlorophenyl)methoxy]-4-fluorophenyl}-2-oxo-2H-[1,3'-bipyridin]-5-yl]-1-methylpyrimidine-2,4(1H,3H)-dione, 3C-like proteinase nsp5 | 著者 | Papini, C, Zhang, C.H, Jorgensen, W.L, Anderson, K.S. | 登録日 | 2023-10-25 | 公開日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Proof-of-concept studies with a computationally designed M pro inhibitor as a synergistic combination regimen alternative to Paxlovid. Proc.Natl.Acad.Sci.USA, 121, 2024
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5YB3
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![BU of 5yb3 by Molmil](/molmil-images/mine/5yb3) | Crystal structure of HP23L/N36 | 分子名称: | Envelope glycoprotein, HP23L | 著者 | Zhang, X, Wang, X, He, Y. | 登録日 | 2017-09-03 | 公開日 | 2018-02-28 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.043 Å) | 主引用文献 | Structural Insights into the Mechanisms of Action of Short-Peptide HIV-1 Fusion Inhibitors Targeting the Gp41 Pocket Front Cell Infect Microbiol, 8, 2018
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1CA5
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![BU of 1ca5 by Molmil](/molmil-images/mine/1ca5) | INTERCALATION SITE OF HYPERTHERMOPHILE CHROMOSOMAL PROTEIN SSO7D/SAC7D BOUND TO DNA | 分子名称: | 5'-D(*GP*TP*GP*AP*TP*CP*AP*C)-3', CHROMOSOMAL PROTEIN SAC7D | 著者 | Su, S, Gao, Y.-G, Robinson, H, Shriver, J.W, Wang, A.H.-J. | 登録日 | 1999-02-23 | 公開日 | 2000-02-23 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal structures of the chromosomal proteins Sso7d/Sac7d bound to DNA containing T-G mismatched base-pairs J.Mol.Biol., 303, 2000
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4KV2
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8UDZ
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![BU of 8udz by Molmil](/molmil-images/mine/8udz) | The Structure of LTBP-49247 Fab Bound to TGFbeta1 Small Latent Complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, LTBP-49247 Fab Heavy Chain, LTBP-49247 Fab Light Chain, ... | 著者 | Streich Jr, F.C, Nicholls, S.B, Boston, C.J, Ramachandran, S. | 登録日 | 2023-09-29 | 公開日 | 2024-07-17 | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | 主引用文献 | An antibody that inhibits TGF-beta 1 release from latent extracellular matrix complexes attenuates the progression of renal fibrosis. Sci.Signal., 17, 2024
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5YJ8
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