1OY0
 
 | | The crystal Structure of the First Enzyme of Pantothenate Biosynthetic Pathway, Ketopantoate Hydroxymethyltransferase from Mycobacterium Tuberculosis Shows a Decameric Assembly and Terminal Helix-Swapping | | 分子名称: | Ketopantoate hydroxymethyltransferase, MAGNESIUM ION | | 著者 | Chaudhuri, B.N, Sawaya, M.R, Kim, C.Y, Waldo, G.S, Park, M.S, Terwilliger, T.C, Yeates, T.O, TB Structural Genomics Consortium (TBSGC) | | 登録日 | 2003-04-03 | | 公開日 | 2003-07-15 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | The Crystal Structure of the First Enzyme in the Pantothenate Biosynthetic Pathway,
Ketopantoate Hydroxymethyltransferase, from M. tuberculosis
Structure, 11, 2003
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2H9L
 | | WDR5delta23 | | 分子名称: | SULFATE ION, WD-repeat protein 5 | | 著者 | Min, J.R, Schuetz, A, Allali-Hassani, A, Martin, F, Loppnau, P, Vedadi, M, Weigelt, J, Sundstrom, M, Edwards, A.M, Arrowsmith, C.H, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | | 登録日 | 2006-06-10 | | 公開日 | 2006-08-01 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Structural basis for molecular recognition and presentation of histone H3 By WDR5.
Embo J., 25, 2006
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5T5G
 | | human SETD8 in complex with MS2177 | | 分子名称: | 7-(2-aminoethoxy)-6-methoxy-2-(pyrrolidin-1-yl)-N-[5-(pyrrolidin-1-yl)pentyl]quinazolin-4-amine, N-lysine methyltransferase KMT5A, UNKNOWN ATOM OR ION | | 著者 | Yu, W, Tempel, W, Babault, N, Ma, A, Butler, K.V, Jin, J, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Brown, P.J, Structural Genomics Consortium (SGC) | | 登録日 | 2016-08-30 | | 公開日 | 2016-09-28 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structure-Based Design of a Covalent Inhibitor of the SET Domain-Containing Protein 8 (SETD8) Lysine Methyltransferase.
J. Med. Chem., 59, 2016
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2GTP
 | | Crystal structure of the heterodimeric complex of human RGS1 and activated Gi alpha 1 | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(i), alpha-1 subunit, ... | | 著者 | Soundararajan, M, Turnbull, A.P, Ugochukwu, E, Gorrec, F, von Delft, F, Weigelt, J, Edwards, A, Arrowsmith, C, Sundstrom, M, Doyle, D.A, Structural Genomics Consortium (SGC) | | 登録日 | 2006-04-28 | | 公開日 | 2006-05-23 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
Proc.Natl.Acad.Sci.Usa, 105, 2008
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2JM5
 | | Solution Structure of the RGS domain from human RGS18 | | 分子名称: | Regulator of G-protein signaling 18 | | 著者 | Higman, V.A, Leidert, M, Bray, J, Elkins, J, Soundararajan, M, Doyle, D.A, Gileadi, C, Phillips, C, Schoch, G, Yang, X, Brockmann, C, Schmieder, P, Diehl, A, Sundstrom, M, Arrowsmith, C, Weigelt, J, Edwards, A, Oschkinat, H, Ball, L.J, Structural Genomics Consortium (SGC) | | 登録日 | 2006-10-11 | | 公開日 | 2006-10-24 | | 最終更新日 | 2024-05-08 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
Proc.Natl.Acad.Sci.Usa, 105, 2008
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2JOI
 | | NMR solution structure of hypothetical protein TA0095 from Thermoplasma acidophilum | | 分子名称: | Hypothetical protein Ta0095 | | 著者 | Jimenez, M, Leon, E, Santoro, J, Rico, M, Yee, A, Structural Genomics Consortium (SGC) | | 登録日 | 2007-03-13 | | 公開日 | 2007-10-02 | | 最終更新日 | 2023-12-20 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of the hypothetical protein TA0095 from Thermoplasma acidophilum: A novel superfamily with a two-layer sandwich architecture
Protein Sci., 16, 2007
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2JNU
 | | Solution structure of the RGS domain of human RGS14 | | 分子名称: | Regulator of G-protein signaling 14 | | 著者 | Dowler, E.F, Diehl, A, Bray, J, Elkins, J, Soundararajan, M, Doyle, D.A, Gileadi, C, Phillips, C, Schoch, G.A, Yang, X, Brockmann, C, Leidert, M, Rehbein, K, Schmieder, P, Kuhne, R, Higman, V.A, Sundstrom, M, Arrowsmith, C, Weigelt, J, Edwards, A, Oschkinat, H, Ball, L.J, Structural Genomics Consortium (SGC) | | 登録日 | 2007-02-02 | | 公開日 | 2007-02-27 | | 最終更新日 | 2024-05-08 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
Proc.Natl.Acad.Sci.Usa, 105, 2008
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2QVB
 | | Crystal Structure of Haloalkane Dehalogenase Rv2579 from Mycobacterium tuberculosis | | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, Haloalkane dehalogenase 3 | | 著者 | Mazumdar, P.A, Hulecki, J, Cherney, M.M, Garen, C.R, James, M.N.G, TB Structural Genomics Consortium (TBSGC) | | 登録日 | 2007-08-08 | | 公開日 | 2008-02-12 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.19 Å) | | 主引用文献 | X-ray crystal structure of Mycobacterium tuberculosis haloalkane dehalogenase Rv2579.
Biochim.Biophys.Acta, 1784, 2008
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2GWH
 | | Human Sulfotranferase SULT1C2 in complex with PAP and pentachlorophenol | | 分子名称: | ADENOSINE-3'-5'-DIPHOSPHATE, PENTACHLOROPHENOL, Sulfotransferase 1C2, ... | | 著者 | Tempel, W, Pan, P.W, Dombrovski, L, Allali-Hassani, A, Vedadi, M, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | | 登録日 | 2006-05-04 | | 公開日 | 2006-05-16 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structural and chemical profiling of the human cytosolic sulfotransferases.
Plos Biol., 5, 2007
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2H9M
 | | WDR5 in complex with unmodified H3K4 peptide | | 分子名称: | H3 histone, WD-repeat protein 5 | | 著者 | Min, J.R, Schuetz, A, Allali-Hassani, A, Martin, F, Loppnau, P, Vedadi, M, Weigelt, J, Sundstrom, M, Edwards, A.M, Arrowsmith, C.H, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | | 登録日 | 2006-06-10 | | 公開日 | 2006-08-01 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structural basis for molecular recognition and presentation of histone H3 By WDR5.
Embo J., 25, 2006
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3GPC
 | | Crystal structure of human Acyl-CoA synthetase medium-chain family member 2A (L64P mutation) in a complex with CoA | | 分子名称: | Acyl-coenzyme A synthetase ACSM2A, COENZYME A, MAGNESIUM ION | | 著者 | Pilka, E.S, Kochan, G.T, Yue, W.W, Bhatia, C, Von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Oppermann, U, Structural Genomics Consortium (SGC) | | 登録日 | 2009-03-23 | | 公開日 | 2009-04-07 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structural snapshots for the conformation-dependent catalysis by human medium-chain acyl-coenzyme A synthetase ACSM2A
J.Mol.Biol., 388, 2009
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2HTE
 | | The crystal structure of spermidine synthase from p. falciparum in complex with 5'-methylthioadenosine | | 分子名称: | 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, 5'-DEOXY-5'-METHYLTHIOADENOSINE, SULFATE ION, ... | | 著者 | Qiu, W, Dong, A, Ren, H, Wu, H, Wasney, G, Vedadi, M, Lew, J, Kozieradski, I, Edwards, A.M, Arrowsmith, C.H, Weigelt, J, Sundstrom, M, Plotnikov, A.N, Bochkarev, A, Hui, R, Structural Genomics Consortium (SGC) | | 登録日 | 2006-07-25 | | 公開日 | 2006-08-08 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms.
Mol.Biochem.Parasitol., 151, 2007
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2HQ6
 | | Structure of the Cyclophilin_CeCYP16-Like Domain of the Serologically Defined Colon Cancer Antigen 10 from Homo Sapiens | | 分子名称: | GLYCEROL, IODIDE ION, Serologically defined colon cancer antigen 10 | | 著者 | Walker, J.R, Davis, T, Paramanathan, R, Newman, E.M, Finerty Jr, P.J, Mackenzie, F, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | | 登録日 | 2006-07-18 | | 公開日 | 2006-08-01 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases.
PLoS Biol., 8, 2010
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3Q4T
 | | Crystal structure of Activin receptor type-IIA (ACVR2A) kinase domain in complex with dorsomorphin | | 分子名称: | 1,2-ETHANEDIOL, 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine, Activin receptor type-2A, ... | | 著者 | Chaikuad, A, Alfano, I, Mahajan, P, Cooper, C.D.O, Sanvitale, C, Vollmar, M, Krojer, T, Muniz, J.R.C, Raynor, J, von Delft, F, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A, Structural Genomics Consortium (SGC) | | 登録日 | 2010-12-24 | | 公開日 | 2011-02-09 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | | 主引用文献 | Small Molecules Dorsomorphin and LDN-193189 Inhibit Myostatin/GDF8 Signaling and Promote Functional Myoblast Differentiation.
J.Biol.Chem., 290, 2015
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3Q3J
 | | Crystal structure of plexin A2 RBD in complex with Rnd1 | | 分子名称: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Plexin-A2, ... | | 著者 | Wang, H, Tempel, W, Tong, Y, Guan, X, Shen, L, Buren, L, Zhang, N, Wernimont, A.K, Crombet, L, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Park, H, Structural Genomics Consortium (SGC) | | 登録日 | 2010-12-21 | | 公開日 | 2011-01-12 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.971 Å) | | 主引用文献 | Crystal structure of plexin A2 RBD in complex with Rnd1
to be published
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1N2G
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3S93
 | | Crystal structure of conserved motif in TDRD5 | | 分子名称: | Tudor domain-containing protein 5, UNKNOWN ATOM OR ION | | 著者 | Chao, X, Tempel, W, Bian, C, Kania, J, Wernimont, A.K, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | | 登録日 | 2011-05-31 | | 公開日 | 2011-08-31 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | | 主引用文献 | Crystal structure of conserved motif in TDRD5
to be published
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3PP2
 | | Crystal structure of the pleckstrin homology domain of ArhGAP27 | | 分子名称: | CITRIC ACID, GLYCEROL, Rho GTPase-activating protein 27, ... | | 著者 | Shen, L, Tempel, W, Tong, Y, Nedyalkova, L, Li, Y, Wernimont, A.K, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Park, H, Structural Genomics Consortium (SGC) | | 登録日 | 2010-11-23 | | 公開日 | 2010-12-08 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.421 Å) | | 主引用文献 | Crystal structure of the pleckstrin homology domain of ArhGAP27
to be published
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3QWL
 | | Crystal structure of human TBC1 domain family member 7 | | 分子名称: | TBC1 domain family member 7, UNKNOWN ATOM OR ION | | 著者 | Guan, X, Tempel, W, Tong, Y, Wernimont, A.K, Landry, R, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Park, H, Structural Genomics Consortium (SGC) | | 登録日 | 2011-02-28 | | 公開日 | 2011-06-01 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Crystal structure of human TBC1 domain family member 7
to be published
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2IGQ
 | | Human euchromatic histone methyltransferase 1 | | 分子名称: | S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION, euchromatic histone methyltransferase 1 | | 著者 | Min, J, Wu, H, Antoshenko, T, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | | 登録日 | 2006-09-23 | | 公開日 | 2006-10-24 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural biology of human H3K9 methyltransferases
Plos One, 5, 2010
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1P3H
 | | Crystal Structure of the Mycobacterium tuberculosis chaperonin 10 tetradecamer | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 10 kDa chaperonin, CALCIUM ION | | 著者 | Roberts, M.M, Coker, A.R, Fossati, G, Mascagni, P, Coates, A.R.M, Wood, S.P, TB Structural Genomics Consortium (TBSGC) | | 登録日 | 2003-04-17 | | 公開日 | 2003-07-15 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Mycobacterium tuberculosis chaperonin 10 heptamers self-associate through their biologically active loops
J.BACTERIOL., 185, 2003
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1N2B
 | | Crystal Structure of a Pantothenate Synthetase from M. tuberculosis in complex with AMPCPP and pantoate, higher occupancy of pantoate and lower occupancy of AMPCPP in subunit A | | 分子名称: | DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ETHANOL, GLYCEROL, ... | | 著者 | Wang, S, Eisenberg, D, TB Structural Genomics Consortium (TBSGC) | | 登録日 | 2002-10-22 | | 公開日 | 2003-04-22 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Crystal structures of a pantothenate
synthetase from M. tuberculosis and its
complexes with substrates and a
reaction intermediate
Protein Sci., 12, 2003
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1N2O
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1NL3
 | | CRYSTAL STRUCTURE OF THE SECA PROTEIN TRANSLOCATION ATPASE FROM MYCOBACTERIUM TUBERCULOSIS in APO FORM | | 分子名称: | PREPROTEIN TRANSLOCASE SECA 1 SUBUNIT | | 著者 | Sharma, V, Arockiasamy, A, Ronning, D.R, Savva, C.G, Holzenburg, A, Braunstein, M, Jacobs Jr, W.R, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) | | 登録日 | 2003-01-06 | | 公開日 | 2003-03-04 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Crystal Structure of M. tuberculosis SecA, A Preprotein Translocating ATPase
Proc.Natl.Acad.Sci.USA, 100, 2003
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3R90
 | | Crystal structure of Malignant T cell-amplified sequence 1 protein | | 分子名称: | GLYCEROL, Malignant T cell-amplified sequence 1, SULFATE ION, ... | | 著者 | Hong, B, Dimov, S, Tempel, W, Tong, Y, Wernimont, A.K, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Park, H, Structural Genomics Consortium (SGC) | | 登録日 | 2011-03-24 | | 公開日 | 2011-04-13 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Crystal structure of Malignant T cell-amplified sequence 1 protein
to be published
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