7COA
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8TDQ
| SFX-XFEL structure of CYP121 cocrystallized with substrate cYY | 分子名称: | (3S,6S)-3,6-bis(4-hydroxybenzyl)piperazine-2,5-dione, Mycocyclosin synthase, PROTOPORPHYRIN IX CONTAINING FE, ... | 著者 | Nguyen, R.C, Dasgupta, M, Bhowmick, A, Kern, J.F, Liu, A. | 登録日 | 2023-07-04 | 公開日 | 2023-11-22 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | In Situ Structural Observation of a Substrate- and Peroxide-Bound High-Spin Ferric-Hydroperoxo Intermediate in the P450 Enzyme CYP121. J.Am.Chem.Soc., 145, 2023
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8TDP
| Time-resolved SFX-XFEL crystal structure of CYP121 bound with cYY reacted with peracetic acid for 200 milliseconds | 分子名称: | (3S,6S)-3,6-bis(4-hydroxybenzyl)piperazine-2,5-dione, HYDROGEN PEROXIDE, Mycocyclosin synthase, ... | 著者 | Nguyen, R.C, Dasgupta, M, Bhowmick, A, Kern, J.F, Liu, A. | 登録日 | 2023-07-04 | 公開日 | 2023-11-22 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | In Situ Structural Observation of a Substrate- and Peroxide-Bound High-Spin Ferric-Hydroperoxo Intermediate in the P450 Enzyme CYP121. J.Am.Chem.Soc., 145, 2023
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8SWE
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8JZS
| Outward-facing SLC15A4 dimer | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, lysosomal transporter | 著者 | Zhang, S.S, Chen, X.D, Xie, M. | 登録日 | 2023-07-06 | 公開日 | 2023-09-27 | 最終更新日 | 2023-12-13 | 実験手法 | ELECTRON MICROSCOPY (2.95 Å) | 主引用文献 | Structural basis for recruitment of TASL by SLC15A4 in human endolysosomal TLR signaling. Nat Commun, 14, 2023
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8JZU
| SLC15A4_TASL complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, TLR adapter,Green fluorescent protein, TSLAA-EGPF tag fusion protein | 著者 | Zhang, S.S, Chen, X.D, Xie, M. | 登録日 | 2023-07-06 | 公開日 | 2023-09-27 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.05 Å) | 主引用文献 | Structural basis for recruitment of TASL by SLC15A4 in human endolysosomal TLR signaling. Nat Commun, 14, 2023
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8JZR
| Outward_facing SLC15A4 monomer | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, lysosomal transporter,ALFA tag | 著者 | Zhang, S.S, Chen, X.D, Xie, M. | 登録日 | 2023-07-06 | 公開日 | 2023-09-27 | 最終更新日 | 2023-12-13 | 実験手法 | ELECTRON MICROSCOPY (3.25 Å) | 主引用文献 | Structural basis for recruitment of TASL by SLC15A4 in human endolysosomal TLR signaling. Nat Commun, 14, 2023
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6KJV
| Structure of thermal-stabilised(M9) human GLP-1 receptor transmembrane domain | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Glucagon-like peptide 1 receptor,Endolysin,Glucagon-like peptide 1 receptor, N-{4-[(R)-(3,3-dimethylcyclobutyl)({6-[4-(trifluoromethyl)-1H-imidazol-1-yl]pyridin-3-yl}amino)methyl]benzene-1-carbonyl}-beta-alanine | 著者 | Song, G. | 登録日 | 2019-07-23 | 公開日 | 2019-11-13 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Mutagenesis facilitated crystallization of GLP-1R. Iucrj, 6, 2019
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8JSW
| Human VMAT2 complex with serotonin | 分子名称: | SEROTONIN, Synaptic vesicular amine transporter | 著者 | Jiang, D.H, Wu, D. | 登録日 | 2023-06-20 | 公開日 | 2023-11-29 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (2.84 Å) | 主引用文献 | Transport and inhibition mechanisms of human VMAT2. Nature, 626, 2024
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6KRE
| TRiC at 0.05 mM ADP-AlFx, Conformation 2, 0.05-C2 | 分子名称: | T-complex protein 1 subunit alpha, T-complex protein 1 subunit beta, T-complex protein 1 subunit delta, ... | 著者 | Jin, M, Cong, Y. | 登録日 | 2019-08-21 | 公開日 | 2019-09-18 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (4.45 Å) | 主引用文献 | An ensemble of cryo-EM structures of TRiC reveal its conformational landscape and subunit specificity. Proc.Natl.Acad.Sci.USA, 116, 2019
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8JTA
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8JT9
| Human VMAT2 complex with ketanserin | 分子名称: | 3-[2-[4-(4-fluorophenyl)carbonylpiperidin-1-yl]ethyl]-1~{H}-quinazoline-2,4-dione, Synaptic vesicular amine transporter | 著者 | Jiang, D.H, Wu, D. | 登録日 | 2023-06-21 | 公開日 | 2023-11-29 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (2.97 Å) | 主引用文献 | Transport and inhibition mechanisms of human VMAT2. Nature, 626, 2024
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8JTC
| Human VMAT2 complex with reserpine | 分子名称: | Synaptic vesicular amine transporter, reserpine | 著者 | Jiang, D.H, Wu, D. | 登録日 | 2023-06-21 | 公開日 | 2023-11-29 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (3.52 Å) | 主引用文献 | Transport and inhibition mechanisms of human VMAT2. Nature, 626, 2024
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6KS8
| TRiC at 0.1 mM ADP-AlFx, Conformation 4, 0.1-C4 | 分子名称: | T-complex protein 1 subunit alpha, T-complex protein 1 subunit beta, T-complex protein 1 subunit delta, ... | 著者 | Jin, M, Cong, Y. | 登録日 | 2019-08-23 | 公開日 | 2019-09-18 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (4.69 Å) | 主引用文献 | An ensemble of cryo-EM structures of TRiC reveal its conformational landscape and subunit specificity. Proc.Natl.Acad.Sci.USA, 116, 2019
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6KRD
| TRiC at 0.05 mM ADP-AlFx, Conformation 4, 0.05-C4 | 分子名称: | T-complex protein 1 subunit alpha, T-complex protein 1 subunit beta, T-complex protein 1 subunit delta, ... | 著者 | Jin, M, Cong, Y. | 登録日 | 2019-08-21 | 公開日 | 2019-09-18 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (4.38 Å) | 主引用文献 | An ensemble of cryo-EM structures of TRiC reveal its conformational landscape and subunit specificity. Proc.Natl.Acad.Sci.USA, 116, 2019
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8HJD
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8HJC
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8HIJ
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8HII
| The BRIL-SLC19A1/Fab/Nb ternary complex | 分子名称: | BRIL-SLC19A1 chimera, anti-BRIL Fab heavy chain, anti-BRIL Fab light chain, ... | 著者 | Zhang, Z, Dang, Y. | 登録日 | 2022-11-20 | 公開日 | 2022-12-21 | 最終更新日 | 2023-01-11 | 実験手法 | ELECTRON MICROSCOPY (3.57 Å) | 主引用文献 | Molecular mechanism of substrate recognition by folate transporter SLC19A1. Cell Discov, 8, 2022
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8HIK
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6KS7
| TRiC at 0.1 mM ADP-AlFx, Conformation 1, 0.1-C1 | 分子名称: | T-complex protein 1 subunit alpha, T-complex protein 1 subunit beta, T-complex protein 1 subunit delta, ... | 著者 | Jin, M, Cong, Y. | 登録日 | 2019-08-23 | 公開日 | 2019-09-18 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (4.62 Å) | 主引用文献 | An ensemble of cryo-EM structures of TRiC reveal its conformational landscape and subunit specificity. Proc.Natl.Acad.Sci.USA, 116, 2019
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7DLY
| Crystal structure of Arabidopsis ACS7 mutant in complex with PPG | 分子名称: | (2E,3E)-4-(2-aminoethoxy)-2-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)imino]but-3-enoic acid, 1-aminocyclopropane-1-carboxylate synthase 7 | 著者 | Hao, B, Zhang, Y, Li, X, Rao, Z. | 登録日 | 2020-11-30 | 公開日 | 2021-09-29 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.94 Å) | 主引用文献 | Dual activities of ACC synthase: Novel clues regarding the molecular evolution of ACS genes. Sci Adv, 7, 2021
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7DLW
| Crystal structure of Arabidopsis ACS7 in complex with PPG | 分子名称: | (2E,3E)-4-(2-aminoethoxy)-2-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)imino]but-3-enoic acid, 1-aminocyclopropane-1-carboxylate synthase 7, SULFATE ION | 著者 | Hao, B, Zhang, Y, Li, X, Rao, Z. | 登録日 | 2020-11-30 | 公開日 | 2021-09-29 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | 主引用文献 | Dual activities of ACC synthase: Novel clues regarding the molecular evolution of ACS genes. Sci Adv, 7, 2021
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6KVE
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6AKW
| Crystal structure of RNA dioxygenase bound with an inhibitor | 分子名称: | 2-OXOGLUTARIC ACID, 2-[[2,6-bis(chloranyl)-4-(3,5-dimethyl-1,2-oxazol-4-yl)phenyl]amino]benzoic acid, Alpha-ketoglutarate-dependent dioxygenase FTO | 著者 | Yang, C.-G, Huang, Y, Gan, J. | 登録日 | 2018-09-04 | 公開日 | 2019-05-29 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia. Cancer Cell, 35, 2019
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