9DRC
 
 | | Ternary substrate complex of DNA polymerase iota R71A mutant with DNA (template A) and dTTP | | 分子名称: | CALCIUM ION, DNA (5'-D(P*AP*AP*GP*GP*GP*TP*CP*CP*TP*AP*GP*GP*AP*CP*CP*C)-3'), DNA polymerase iota, ... | | 著者 | Frevert, Z, Reusch, D, Freudenthal, B, Washington, M.T. | | 登録日 | 2024-09-25 | | 公開日 | 2025-07-09 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | Visualizing DNA polymerase iota catalyze Hoogsteen-directed DNA synthesis
Nat Commun, 16, 2025
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7UK2
 | | Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 complexed with NN-390 | | 分子名称: | Hdac6 protein, N-hydroxy-4-{[(propan-2-yl)(2,3,4,5-tetrafluorobenzene-1-sulfonyl)amino]methyl}benzamide, POTASSIUM ION, ... | | 著者 | Erdogan, F, Seo, H.-S, Dhe-Paganon, S. | | 登録日 | 2022-03-31 | | 公開日 | 2022-11-02 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | High Efficacy and Drug Synergy of HDAC6-Selective Inhibitor NN-429 in Natural Killer (NK)/T-Cell Lymphoma.
Pharmaceuticals, 15, 2022
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7UXY
 | | Isoreticular, interpenetrating co-crystal of protein variant Replication Initiator Protein REPE54 (L53G,Q54G,E55G) and symmetrical expanded duplex (31mer) containing the cognate REPE54 sequence and an additional G-C rich sequence. | | 分子名称: | DNA (5'-D(A*CP*CP*CP*GP*GP*AP*CP*CP*TP*GP*TP*P*GP*AP*CP*AP*AP*AP*TP*TP*GP*CP*CP*CP*TP*CP*AP*GP*AP*CP*GP*G)-3'), DNA (5'-D(A*GP*CP*CP*GP*TP*CP*TP*GP*AP*GP*GP*P*GP*CP*AP*AP*TP*TP*TP*GP*TP*CP*AP*CP*AP*GP*GP*TP*CP*CP*GP*G)-3'), MAGNESIUM ION, ... | | 著者 | Orun, A.R, Snow, C.D. | | 登録日 | 2022-05-06 | | 公開日 | 2023-05-17 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | | 主引用文献 | Modular Protein-DNA Cocrystals as Precise, Programmable Assembly Scaffolds.
Acs Nano, 17, 2023
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4FE1
 | | Improving the Accuracy of Macromolecular Structure Refinement at 7 A Resolution | | 分子名称: | 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, 1,2-DISTEAROYL-MONOGALACTOSYL-DIGLYCERIDE, BETA-CAROTENE, ... | | 著者 | Fromme, R, Adams, P.D, Fromme, P, Levitt, M, Schroeder, G.F, Brunger, A.T. | | 登録日 | 2012-05-29 | | 公開日 | 2012-08-15 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (4.9228 Å) | | 主引用文献 | Improving the accuracy of macromolecular structure refinement at 7 A resolution.
Structure, 20, 2012
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6OPJ
 | | Menin in complex with peptide inhibitor 25 | | 分子名称: | DIMETHYL SULFOXIDE, Menin, Peptide inhibitor 25, ... | | 著者 | Linhares, B.M, Fortuna, P, Cierpicki, T, Grembecka, J, Berlicki, L. | | 登録日 | 2019-04-25 | | 公開日 | 2020-09-02 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.5006572 Å) | | 主引用文献 | Covalent and noncovalent constraints yield a figure eight-like conformation of a peptide inhibiting the menin-MLL interaction.
Eur.J.Med.Chem., 207, 2020
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8P0E
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6P0J
 | | Crystal structure of GDP-bound human RalA | | 分子名称: | CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, Ras-related protein Ral-A | | 著者 | Bum-Erdene, K, Gonzalez-Gutierrez, G, Liu, D, Meroueh, S.O. | | 登録日 | 2019-05-17 | | 公開日 | 2020-03-04 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.31 Å) | | 主引用文献 | Small-molecule covalent bond formation at tyrosine creates a binding site and inhibits activation of Ral GTPases.
Proc.Natl.Acad.Sci.USA, 117, 2020
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6PHJ
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6PHO
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6PHK
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6PHP
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7PA0
 | | NaK C-DI F92A mutant with Rb+ and K+ | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, POTASSIUM ION, Potassium channel protein, ... | | 著者 | Minniberger, S, Plested, A.J.R. | | 登録日 | 2021-07-28 | | 公開日 | 2022-08-10 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Asymmetry and Ion Selectivity Properties of Bacterial Channel NaK Mutants Derived from Ionotropic Glutamate Receptors.
J.Mol.Biol., 435, 2023
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6PQ7
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7PUX
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6PHN
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6PHI
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6PHM
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8Q7S
 | | Crystal structure of the SARS-CoV-2 RBD (Wuhan) with neutralizing VHHs Ma6F06 and Re21H01 | | 分子名称: | 1,2-ETHANEDIOL, 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE, GLYCEROL, ... | | 著者 | Guttler, T, Aksu, M, Gorlich, D. | | 登録日 | 2023-08-16 | | 公開日 | 2023-12-20 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Nanobodies to multiple spike variants and inhalation of nanobody-containing aerosols neutralize SARS-CoV-2 in cell culture and hamsters.
Antiviral Res., 221, 2023
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7PV8
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7QIV
 | | Structure of human C3b in complex with the EWE nanobody | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3 beta chain, Complement C3b alpha' chain, ... | | 著者 | Pedersen, H, Andersen, G.R. | | 登録日 | 2021-12-16 | | 公開日 | 2022-02-16 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structure-Guided Engineering of a Complement Component C3-Binding Nanobody Improves Specificity and Adds Cofactor Activity.
Front Immunol, 13, 2022
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6PHL
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6PHQ
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8PXV
 | | Targeting extended blood antigens by Akkermansia muciniphila enzymes unveils a missing link for generating universal donor blood | | 分子名称: | Beta-N-acetylhexosaminidase, GLYCEROL, SODIUM ION, ... | | 著者 | Weikum, J, Jensen, M, Abou Hachem, M, Morth, J.P. | | 登録日 | 2023-07-24 | | 公開日 | 2024-02-28 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Akkermansia muciniphila exoglycosidases target extended blood group antigens to generate ABO-universal blood.
Nat Microbiol, 9, 2024
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8PXU
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8PXT
 | | Targeting extended blood antigens by Akkermansia muciniphila enzymes unveils a missing link for generating universal donor blood | | 分子名称: | 2-acetamido-2-deoxy-beta-D-galactopyranose, Beta-N-acetylhexosaminidase, CHLORIDE ION, ... | | 著者 | Jensen, M, Abou Hachem, M, Morth, J.P. | | 登録日 | 2023-07-24 | | 公開日 | 2024-02-28 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Akkermansia muciniphila exoglycosidases target extended blood group antigens to generate ABO-universal blood.
Nat Microbiol, 9, 2024
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