8K7T
 
 | | Mouse Fc epsilon RI in complex with mIgE Fc | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, High affinity immunoglobulin epsilon receptor subunit alpha, High affinity immunoglobulin epsilon receptor subunit beta, ... | | 著者 | Zhang, Z, Yui, M, Ohto, U, Shimizu, T. | | 登録日 | 2023-07-27 | | 公開日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (3.71 Å) | | 主引用文献 | Mouse Fc epsilon RI in complex withMouse Fc epsilon RI in complex with mIgE Fc mIgE Fc
To Be Published
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2OPW
 | | Crystal structure of human phytanoyl-CoA dioxygenase PHYHD1 (apo) | | 分子名称: | PHYHD1 protein | | 著者 | Zhang, Z, Butler, D, McDonough, M.A, Kavanagh, K.L, Bray, J.E, Ng, S.S, von Delft, F, Arrowsmith, C.H, Weigelt, J, Edwards, A, Sundstrom, M, Schofield, C.J, Oppermann, U, Structural Genomics Consortium (SGC) | | 登録日 | 2007-01-30 | | 公開日 | 2007-03-06 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Crystal structure of human phytanoyl-CoA dioxygenase PHYHD1 (apo)
To be Published
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5GMF
 | | Crystal structure of monkey TLR7 in complex with guanosine and polyU | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | Zhang, Z, Ohto, U, Shimizu, T. | | 登録日 | 2016-07-14 | | 公開日 | 2016-11-02 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structural Analysis Reveals that Toll-like Receptor 7 Is a Dual Receptor for Guanosine and Single-Stranded RNA
Immunity, 45, 2016
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5UAR
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5GMG
 | | Crystal structure of monkey TLR7 in complex with loxoribine and polyU | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-azanyl-9-[(2~{R},3~{R},4~{S},5~{R})-5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolan-2-yl]-7-prop-2-enyl-1~{H}-purine-6,8-dione, ... | | 著者 | Zhang, Z, Ohto, U, Shimizu, T. | | 登録日 | 2016-07-14 | | 公開日 | 2016-11-02 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structural Analysis Reveals that Toll-like Receptor 7 Is a Dual Receptor for Guanosine and Single-Stranded RNA
Immunity, 45, 2016
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5GMH
 | | Crystal structure of monkey TLR7 in complex with R848 | | 分子名称: | 1-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Zhang, Z, Ohto, U, Shimizu, T. | | 登録日 | 2016-07-14 | | 公開日 | 2016-11-02 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structural Analysis Reveals that Toll-like Receptor 7 Is a Dual Receptor for Guanosine and Single-Stranded RNA
Immunity, 45, 2016
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8GJL
 | | multi-drug efflux pump RE-CmeB bound with Ciprofloxacin | | 分子名称: | 1-CYCLOPROPYL-6-FLUORO-4-OXO-7-PIPERAZIN-1-YL-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID, Efflux pump membrane transporter | | 著者 | Zhang, Z. | | 登録日 | 2023-03-16 | | 公開日 | 2023-05-31 | | 最終更新日 | 2023-10-04 | | 実験手法 | ELECTRON MICROSCOPY (3.44 Å) | | 主引用文献 | Cryo-Electron Microscopy Structures of a Campylobacter Multidrug Efflux Pump Reveal a Novel Mechanism of Drug Recognition and Resistance.
Microbiol Spectr, 11, 2023
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8GJJ
 | | Multi-drug efflux pump RE-CmeB Apo form | | 分子名称: | Efflux pump membrane transporter | | 著者 | Zhang, Z. | | 登録日 | 2023-03-15 | | 公開日 | 2023-05-31 | | 最終更新日 | 2023-10-04 | | 実験手法 | ELECTRON MICROSCOPY (3.08 Å) | | 主引用文献 | Cryo-Electron Microscopy Structures of a Campylobacter Multidrug Efflux Pump Reveal a Novel Mechanism of Drug Recognition and Resistance.
Microbiol Spectr, 11, 2023
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8GK4
 | | Multi-drug efflux pump RE-CmeB bound with Chloramphenicol | | 分子名称: | CHLORAMPHENICOL, Efflux pump membrane transporter | | 著者 | Zhang, Z. | | 登録日 | 2023-03-17 | | 公開日 | 2023-05-31 | | 最終更新日 | 2023-10-04 | | 実験手法 | ELECTRON MICROSCOPY (3.12 Å) | | 主引用文献 | Cryo-Electron Microscopy Structures of a Campylobacter Multidrug Efflux Pump Reveal a Novel Mechanism of Drug Recognition and Resistance.
Microbiol Spectr, 11, 2023
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8GK0
 | | Multi-drug efflux pump RE-CmeB bound with Erythromycin | | 分子名称: | ERYTHROMYCIN A, Efflux pump membrane transporter | | 著者 | Zhang, Z. | | 登録日 | 2023-03-16 | | 公開日 | 2023-06-07 | | 最終更新日 | 2023-10-04 | | 実験手法 | ELECTRON MICROSCOPY (3.44 Å) | | 主引用文献 | Cryo-Electron Microscopy Structures of a Campylobacter Multidrug Efflux Pump Reveal a Novel Mechanism of Drug Recognition and Resistance.
Microbiol Spectr, 11, 2023
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8GJK
 | | Multi-drug efflux pump RE-CmeB bound with ampicillin | | 分子名称: | (2R,4S)-2-[(R)-{[(2R)-2-amino-2-phenylacetyl]amino}(carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, Efflux pump membrane transporter | | 著者 | Zhang, Z. | | 登録日 | 2023-03-16 | | 公開日 | 2023-05-31 | | 最終更新日 | 2023-10-04 | | 実験手法 | ELECTRON MICROSCOPY (3.16 Å) | | 主引用文献 | Cryo-Electron Microscopy Structures of a Campylobacter Multidrug Efflux Pump Reveal a Novel Mechanism of Drug Recognition and Resistance.
Microbiol Spectr, 11, 2023
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6JIO
 | | Human LXR-beta in complex with a ligand | | 分子名称: | Oxysterols receptor LXR-beta, tert-butyl 7-amino-3,4-dihydroisoquinoline-2(1H)-carboxylate | | 著者 | Zhang, Z, Zhou, H. | | 登録日 | 2019-02-22 | | 公開日 | 2019-10-16 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Identify liver X receptor beta modulator building blocks by developing a fluorescence polarization-based competition assay.
Eur.J.Med.Chem., 178, 2019
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8UVK
 | | CosR DNA bound form II | | 分子名称: | DI(HYDROXYETHYL)ETHER, DNA (5'-D(*AP*AP*TP*TP*AP*AP*GP*AP*TP*AP*TP*TP*AP*TP*TP*AP*AP*CP*CP*AP*A)-3'), DNA (5'-D(*TP*TP*GP*GP*TP*TP*AP*AP*TP*AP*AP*TP*AP*TP*CP*TP*TP*AP*AP*TP*T)-3'), ... | | 著者 | Zhang, Z. | | 登録日 | 2023-11-03 | | 公開日 | 2024-01-31 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | | 主引用文献 | Structural basis of DNA recognition of the Campylobacter jejuni CosR regulator.
Mbio, 15, 2024
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8UUZ
 | | Campylobacter jejuni CosR apo form | | 分子名称: | DNA-binding response regulator | | 著者 | Zhang, Z. | | 登録日 | 2023-11-02 | | 公開日 | 2024-01-31 | | 最終更新日 | 2024-04-03 | | 実験手法 | ELECTRON MICROSCOPY (3.77 Å) | | 主引用文献 | Structural basis of DNA recognition of the Campylobacter jejuni CosR regulator.
Mbio, 15, 2024
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8UVX
 | | CosR DNA bound form I | | 分子名称: | DNA (5'-D(*AP*TP*AP*TP*CP*TP*TP*AP*AP*TP*TP*TP*TP*GP*GP*TP*TP*AP*AP*TP*A)-3'), DNA (5'-D(*TP*AP*TP*TP*AP*AP*CP*CP*AP*AP*AP*AP*TP*TP*AP*AP*GP*AP*TP*AP*T)-3'), DNA-binding response regulator | | 著者 | Zhang, Z. | | 登録日 | 2023-11-05 | | 公開日 | 2024-01-31 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structural basis of DNA recognition of the Campylobacter jejuni CosR regulator.
Mbio, 15, 2024
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6MSM
 | | Phosphorylated, ATP-bound human cystic fibrosis transmembrane conductance regulator (CFTR) | | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, ADENOSINE-5'-TRIPHOSPHATE, CHOLESTEROL, ... | | 著者 | Zhang, Z, Liu, F, Chen, J. | | 登録日 | 2018-10-16 | | 公開日 | 2018-11-21 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Molecular structure of the ATP-bound, phosphorylated human CFTR.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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7E3J
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7YTP
 | | TLR7 in complex with an inhibitor | | 分子名称: | (2R,6R)-4-(8-cyanoquinolin-5-yl)-N-[(3S,4R)-4-fluoranylpyrrolidin-3-yl]-6-methyl-morpholine-2-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Zhang, Z, Ohto, U, Shimizu, T. | | 登録日 | 2022-08-15 | | 公開日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (2.77 Å) | | 主引用文献 | TLR7 in complex with an inhibitor
To Be Published
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8HD0
 | | Cell divisome sPG hydrolysis machinery FtsEX-EnvC | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Cell division ATP-binding protein FtsE, Cell division protein FtsX, ... | | 著者 | Zhang, Z, Chen, Y. | | 登録日 | 2022-11-03 | | 公開日 | 2023-11-08 | | 実験手法 | ELECTRON MICROSCOPY (3.11 Å) | | 主引用文献 | Structural insight into the septal peptidoglycan hydrolysis machinery of bacterial cell division
To Be Published
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6IF5
 | | Crystal structure of monkey TLR7 in complex with 2',3'-cGMP (Guanosine 2',3'-cyclic phosphate) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GUANOSINE-5'-PHOSPHATE-2',3'-CYCLIC PHOSPHATE, ... | | 著者 | Zhang, Z, Ohto, U, Shimizu, T. | | 登録日 | 2018-09-18 | | 公開日 | 2019-01-30 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural Analyses of Toll-like Receptor 7 Reveal Detailed RNA Sequence Specificity and Recognition Mechanism of Agonistic Ligands.
Cell Rep, 25, 2018
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6JCJ
 | | Structure of crolibulin in complex with tubulin | | 分子名称: | (4R)-2,7,8-triamino-4-(3-bromo-4,5-dimethoxyphenyl)-4H-1-benzopyran-3-carbonitrile, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... | | 著者 | Zhang, Z, Yang, J. | | 登録日 | 2019-01-29 | | 公開日 | 2019-03-13 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Molecular mechanism of crolibulin in complex with tubulin provides a rationale for drug design.
Biochem. Biophys. Res. Commun., 511, 2019
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7WGE
 | | Human NLRP1 complexed with thioredoxin | | 分子名称: | MAGNESIUM ION, NACHT, LRR and PYD domains-containing protein 1, ... | | 著者 | Zhang, Z, Ohto, U, Shimizu, T. | | 登録日 | 2021-12-28 | | 公開日 | 2023-07-05 | | 最終更新日 | 2023-10-18 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structural basis for thioredoxin-mediated suppression of NLRP1 inflammasome.
Nature, 622, 2023
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8I96
 | | Cryo-EM structure of TLR7/TH-407b complex | | 分子名称: | (1S,3R)-5-[4-(8-nitroquinolin-5-yl)piperazin-1-yl]carbonyladamantan-2-one, Toll-like receptor 7 | | 著者 | Zhang, Z. | | 登録日 | 2023-02-06 | | 公開日 | 2024-08-14 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Cryo-EM structure of TLR7/TH-407b complex
To Be Published
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7DUP
 | | Apo structure of wild type Bt4394, a GH20 family sulfoglycosidase | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Beta-N-acetylhexosaminidase, CHLORIDE ION, ... | | 著者 | Zhang, Z, He, Y, Jin, Y. | | 登録日 | 2021-01-10 | | 公開日 | 2022-01-19 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | | 主引用文献 | Mechanistic and Structural Insights into the Specificity and Biological Functions of Bacterial Sulfoglycosidases
Acs Catalysis, 13, 2023
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7DVA
 | | Structure of wild type Bt4394, a GH20 family sulfoglycosidase, in complex with 6S-GlcNAc | | 分子名称: | 2-acetamido-2-deoxy-6-O-sulfo-beta-D-glucopyranose, Beta-N-acetylhexosaminidase, GLYCEROL | | 著者 | Zhang, Z, He, Y, Jin, Y. | | 登録日 | 2021-01-13 | | 公開日 | 2022-01-19 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Mechanistic and Structural Insights into the Specificity and Biological Functions of Bacterial Sulfoglycosidases
Acs Catalysis, 13, 2023
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